Chiral analysis for environmental applications

Bester, Kai

doi:10.1007/s00216-003-1859-4

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…The current status of spectroscopic experiments, confirming molecular parity violation, is reviewed in [33]. Nowadays, enantiomer separation and enantiomer selectivity play a significant role in agrochemical, electronic, and pharmaceutical as well as food, flavor and fragrance industries (cf., e.g., [2,8,9,13,23,29]). The relevance of chirality in drug design became apparent on occasion of the so-called 'Contergan scandal' or 'thalidomide disaster' in the sixties of the last century when worldwide thousands of children were born with extremely severe deformities after their mothers had taken this sleeping drug in early pregnancy.…”

Section: Left-and Right-handed Enantiomermentioning

confidence: 99%

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

et al. 2015

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Abstract. Enantiomers are chiral objects such as chemical molecules that can be distinguished by their handedness. They typically occur as racemic compounds of left-and right-handed species which may have completely different properties. Therefore, in applications such as drug design in pharmacology, enantiomer separation is an important issue. Here, we present a new technology for enantiomer separation by surface acoustic wave generated vorticity patterns consisting of pairwise counter-rotating vortices in a carrier fluid. The enantiomers are injected onto the surface of the fluid between two counter-rotating vortices such that right-handed (left-handed) enantiomers get attracted by left-rotating (right-rotating) vortices. In particular, we are concerned with the numerical simulation of this separation process by an application of the finite element immersed boundary method which relies on the solution of a coupled system consisting of the incompressible NavierStokes equations and the equations of motion of the immersed enantiomers described with respect to an Eulerian and a Lagrangian coordinate system. For a model system of deformable, initially L-shaped enantiomers the results of the numerical simulations reveal a perfect separation.

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Section: Left-and Right-handed Enantiomermentioning

confidence: 99%

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

et al. 2015

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“…Formation of enantiomeric ratios differing from 1 starting from technical racemates are used as a strong clue for biodegradation. 20 In the past there was some discussion whether there is transformation of HHCB at all, and if yes, whether this is biodegradation or (photo) oxidation. Thus enantioselective analysis was used to obtain data on the mechanism of transformation.…”

Section: Enantioselective Determination For the Verification Of Trans...mentioning

confidence: 99%

“…Additionally the chiral measurements on the other hand can be more precise, as they are relative measurements. 20 In Fig. 5 the separation of the enantiomers and diastereomers of HHCB-lactone is shown, while the elution order determined by Meyer 19 is used.…”

Section: Enantioselective Determination For the Verification Of Trans...mentioning

confidence: 99%

Polycyclic musks in the Ruhr catchment area—transport, discharges of waste water, and transformations of HHCB, AHTN and HHCB-lactone

Bester

2005

J. Environ. Monit.

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The polycyclic musk fragrance compounds HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-benzopyran; trade name, e.g. galaxolide) and AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene, trade name, e.g. tonalide) and the transformation product of HHCB (HHCB-lactone) were analysed in surface water samples and sewage treatment plants (STP) effluents in the Ruhr megalopolis. The STPs were the dominant source for these pollutants. In the part of the river where the drinking water is extracted from the river, about 60 ng L(-1) HHCB, 10 ng L(-1) AHTN and 20-30 ng L(-1) HHCB-lactone were found as typical riverine concentrations, while none of the compounds were detected near the spring of the river. On the other hand sewage treatment plant effluents exhibited concentrations up to 600 ng L(-1). The STP's effluent resulted in elevated concentrations in some parts of the river and in the lakes into which they discharge. As some of the plants emit HHCB-lactone with a significantly changed enantiomeric pattern, biotransformation of HHCB to HHCB-lactone occurs in some waste water treatment plants operating with activated sludge. In those parts of the river where no relevant discharges of waste water or fresh water takes place neither the concentration nor the pattern changes significantly. This holds true especially for the HHCB versus HHCB-lactone ratios which indicates degradation less than 15% of the HHCB inventory in the river Ruhr itself. In other rivers, such as the Rhine, higher levels of HHCB-lactone in comparison to HHCB were detected (ratio 1 : 1).

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“…Chiral molecules can create different effects on many biomacromolecules or biological processes because of the high enantioselectivity in nature and life 1–3. For example, the amount and morphous of biological events (such as immune cells, calf thymus single‐stranded DNA and plasmid DNA molecules) which were adsorbed onto the chiral surfaces exhibited remarkable difference 4–6.…”

Section: Introductionmentioning

confidence: 99%

Selective response of antigen‐antibody reactions on chiral surfaces modified with 1,2‐diphenylethylenediamine enantiomers

Zhou

Wang

Qiao

et al. 2011

Surface & Interface Analysis

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Chiral analysis for environmental applications

Cited by 8 publications

References 17 publications

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

Polycyclic musks in the Ruhr catchment area—transport, discharges of waste water, and transformations of HHCB, AHTN and HHCB-lactone

Selective response of antigen‐antibody reactions on chiral surfaces modified with 1,2‐diphenylethylenediamine enantiomers

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