Chip-based refractive index detection using a single point evanescent wave probe

Jakeway, Stephen C.; Mello, Andrew J. de

doi:10.1039/b104350c

Cited by 18 publications

(13 citation statements)

References 26 publications

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“…For example, P-TIRFM measurements have been carried out for cytochrome c [135] and planar membranes [133] deposited on such surfaces. Third, microfluidic devices will increase the throughput of TIRFM measurements [221][222][223][224][225]. Second, the combination of AFM and TIRFM is likely to enable new types of biophysical measurements.…”

Section: Emerging Methodsmentioning

confidence: 99%

Fluorescence Spectroscopy in Biology

2005

Springer Series on Fluorescence

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Volume Editors: M. Hof · R. Hutterer · V. Fidler 3 About this series:Fluorescence spectroscopy, fluorescence imaging and fluorescent probes are indispensible tools in numerous fields of modern medicine and science, including molecular biology, biophysics, biochemistry, clinical diagnosis and analytical and environmental chemistry. Applications stretch from spectroscopy and sensor technology to microscopy and imaging, to single molecule detection, to the development of novel fluorescent probes, and to proteomics and genomics. The Springer Series on Fluorescence aims at publishing stateof-the-art articles that can serve as invaluable tools for both practitioners and researchers being active in this highly interdisciplinary field.The carefully edited collection of papers in each volume will give continuous inspiration for new research and will point to exciting new trends.The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Cover-design:

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Section: Emerging Methodsmentioning

confidence: 99%

Fluorescence Spectroscopy in Biology

2005

Springer Series on Fluorescence

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“…DeMello and colleagues have introduced total internal reflection detection into the refractive index detection for the micro-channel chip, 39 and have achieved a label-free chip screening for carbohydrates, which was based on a careful evaluation for its reliability. DeMello and colleagues have introduced total internal reflection detection into the refractive index detection for the micro-channel chip, 39 and have achieved a label-free chip screening for carbohydrates, which was based on a careful evaluation for its reliability.…”

Section: Other Laser-based Refractive Index Detectionmentioning

confidence: 99%

Laser-based refractive index detection for micro-channels

Xiong

2011

Analyst

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Laser-based refractive index detection, based upon refractive index changes in micro-channels, is a kind of laser-based optical determination for solutions. As it is capable of label-free determination, it has been regarded as a considerable growth prospect. The key aspect in related researches lay in the development of novel detection configurations, which would possibly result in better sensitivity. Over the past decade, micro-channel laser-based refractive index detection has been significantly improved, resulting in traversed, hologram-based, back-scattered, retro-reflected interference, optical ring resonant, etc., detection configurations. Moreover, laser-based refractive index detection has been combined with other laser-based detection strategies, in order to pursue a universal and sensitive detection. And last but not least, some utilizations of laser-based refractive index detection have been reported, while both advantages and drawbacks exist. In this paper, laser-based refractive index detection for micro-channels will be reviewed in proceeding sequence.

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“…The idea is to create supported membranes containing density gradients of reconstituted receptors in one direction and concentration gradients of soluble factors in the other direction by use of microfludic means. Microfluidic chambers have previously been used both with FCS (e.g., Foquet et al, 2004; Foquet et al, 2002; Dittrich and Schwille, 2002) and with TIRFM (Jin et al, 2004; Yang et al, 2003; Yang et al, 2001; Jakeway and de Mello, 2001). In this imagined configuration, fluorescence fluctuation correlation functions calculated in a pixel-dependent manner could at least in theory provide a full spectrum of the surface association and dissociation kinetic rates as a function of the receptor density as well as the solution concentrations of soluble reactants.…”

Section: Future Directionsmentioning

confidence: 99%

Total internal reflection with fluorescence correlation spectroscopy: Applications to substrate-supported planar membranes

Thompson

Wang

Navaratnarajah

2009

Journal of Structural Biology

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In this review paper, the conceptual basis and experimental design of total internal reflection with fluorescence correlation spectroscopy (TIR-FCS) is described. The few applications to date of TIR-FCS to supported membranes are discussed, in addition to a variety of applications not directly involving supported membranes. Methods related, but not technically equivalent, to TIR-FCS are also summarized. Future directions for TIR-FCS are outlined.

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Chip-based refractive index detection using a single point evanescent wave probe

Cited by 18 publications

References 26 publications

Fluorescence Spectroscopy in Biology

Fluorescence Spectroscopy in Biology

Laser-based refractive index detection for micro-channels

Total internal reflection with fluorescence correlation spectroscopy: Applications to substrate-supported planar membranes

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