Chip-based cartilage oligomeric matrix protein detection in serum and synovial fluid for osteoarthritis diagnosis

Song, Seung Yeon; Han, Yong Duk; Hong, Sung Yub; Kim, Kangil; Yang, Sang Sik; Min, Byoung Hyun

doi:10.1016/j.ab.2011.09.012

Cited by 25 publications

(9 citation statements)

References 26 publications

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“…COMP is found predominantly in cartilage, and recent studies have demonstrated that COMP expression can also be identified in other structures such as the ligaments, tendons, menisci, and synovial membrane [10, 11]. Since its appearance, the diagnostic value of serum COMP for OA as well as its correlation with disease progression and severity has been frequently and broadly assessed [9, 12–14]. However, the efficiency of serum COMP as biomarker for OA diagnosis is still in controversy.…”

Section: Introductionmentioning

confidence: 99%

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

2018

J Orthop Surg Res

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BackgroundThe measurement of cartilage oligomeric matrix protein (COMP) has become a novel way for the diagnosis of knee osteoarthritis (OA). However, no conclusive correlation has been drawn between COMP and knee OA. The purpose of this study was to examine the utility of serum COMP as biomarker for knee OA and its relation with disease severity.MethodsA systematic search on PubMed, ScienceDirect, and EMBASE was conducted in January 2018 using certain keywords. Initial search yielded a total of 285 publications, and 35 articles were reviewed in full-text. Eventually, nine studies were included in the analysis. All the retrieved studies used Kellgren-Lawrence (K-L) classification for knee OA and provided available data of serum COMP in OA patients and healthy controls. Sensitivity analysis was performed by removing one study result at a time to detect the impact of each study have on the overall effect and to test the stability of the cumulative result. Subgroup study based on K-L grade system was also conducted to disclose the correlation between serum COMP and knee OA disease severity.ResultsPooled analysis of nine studies demonstrated a significant elevation of serum COMP in knee OA patients (SMD 0.81, [95% CI, 0.36, 1.25], P = 0.0004) compared with controls. In comparisons between K-L 1–4 and controls, significantly higher serum COMP was detected in all three subgroups except K-L grade 1 versus control. Comparisons among K-L grades 1–4 revealed significantly higher serum COMP levels in patients with more serious than less serious disease stage. However, the elevation in patients with K-L grade 3 did not reach statistical significance when compared with K-L grade 1 patients.ConclusionThe overall analysis showed significantly higher serum COMP in knee OA patients compared to controls which indicate the potential ability of serum COMP in differentiating knee OA patients from healthy subjects. Pooled statistic of our meta-analysis showed that serum COMP levels were effective in distinguishing patients with K-L ≥ 2.

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Section: Introductionmentioning

confidence: 99%

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

2018

J Orthop Surg Res

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“…Song et al, 27 developed a method to detect COMP using fluoro-microbead guiding chip (FMGC)-based immunoassays and compared it with commercial ELISAs for COMP. The FMGC-based immunoassay clearly distinguished immunospecific from nonspecific binding and thus offers a new approach for detecting COMP and other clinically relevant OA biomarkers in human blood and synovial fluid.…”

Section: Introductionmentioning

confidence: 99%

Osteoarthritis year 2012 in review: biomarkers

Mobasheri

2012

Osteoarthritis and Cartilage

106

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Novel OA biomarkers are needed for sub-clinical disease diagnosis. Proteomic techniques are beginning to yield useful data and deliver new OA biomarkers in serum and urine. Combining biochemical markers with tissue and cell imaging techniques and bioinformatics (i.e., machine learning, clustering, data visualization) may facilitate the development of biomarker combinations enabling earlier detection of OA.

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“…These properties can make the analysis of SF from OA joints challenging. Consequently, methods to reduce SF viscosity by dilution and/or hyaluronidase (HAse) treatment are routinely used before a variety of analytic techniques (Song et al, 2012;Mateos et al, 2012;Sugiuchi et al, 2005;de Jager et al, 2007;Ekmann et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Hyaluronidase treatment of synovial fluid to improve assay precision for biomarker research using multiplex immunoassay platforms

Jayadev

Rout

Price

et al. 2012

Journal of Immunological Methods

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Chip-based cartilage oligomeric matrix protein detection in serum and synovial fluid for osteoarthritis diagnosis

Cited by 25 publications

References 26 publications

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

Osteoarthritis year 2012 in review: biomarkers

Hyaluronidase treatment of synovial fluid to improve assay precision for biomarker research using multiplex immunoassay platforms

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