Chios mastic gum neutral extract and isolated tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells

Loizou, Stella; Paraschos, S.; Mitaku, Sofia; Chrousos, G. P.; Lekakis, Ioannis; Moutsatsou, Paraskevi

doi:10.1055/s-0028-1084079

Cited by 1 publication

(3 citation statements)

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“…βS also exerts beneficial effects on the cytokine cascade by targeting NF-κB. The inhibition of NF-κB by βS has been extensively investigated, with published findings that are in line with our data [13,33,34]. The immunoblot and confocal analyses of lipopolysaccharide-(LPS-) stimulated intestinal and peritoneal mouse macrophages by Kim et al [33] showed that βS inhibits the phosphorylation and nuclear translocation of the p65 subunit of NF-κB.…”

Section: Discussionsupporting

confidence: 88%

“…Several in vitro studies have revealed βS to possess anti-inflammatory properties. βS has been shown to have antiatherogenic potential through its anti-inflammatory action on human aortic endothelial cells [13]. Similarly, it has been reported that βS causes a dose-dependent inhibition of IL-6 and TNF-α in endotoxin-activated human monocytes [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…βS has been shown to have antiatherogenic potential through its anti-inflammatory action on human aortic endothelial cells [13]. Similarly, it has been reported that βS causes a dose-dependent inhibition of IL-6 and TNF-α in endotoxin-activated human monocytes [13,14]. It has been found that βS has beneficial effects on the immune system by increasing the number of viable peripheral blood mononuclear cells (PBMCs) and activating the swine dendritic cells (DCs) [15].…”

Section: Introductionmentioning

confidence: 99%

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β-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling

Kasirzadeh

Ghahremani

Setayesh

et al. 2021

BioMed Research International

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Purpose. Sepsis originates from the host inflammatory response, especially to bacterial infections, and is considered one of the main causes of death in intensive care units. Various agents have been developed to inhibit mediators of the inflammatory response; one prospective agent is β-sitosterol (βS), a phytosterol with a structure similar to cholesterol. This study is aimed at evaluating the effects of βS on the biomarkers of inflammation and liver function in cecal ligation and puncture- (CLP-) induced septic rats. Methods. Thirty male Wistar rats were divided equally into six groups as follows: sham, CLP, CLP+dexamethasone (DX, 0.2 mg/kg), CLP+βS (1 mg/kg), CLP+imipenem (IMI, 20 mg/kg), and CLP+IMI (20 mg/kg)+βS (1 mg/kg). Serum levels of IL-1β, IL-6, IL-10, AST, ALT, and liver glutathione (GSH) were assessed by ELISA. Liver expression levels of TNF-α and NF-κBi mRNAs were evaluated by RT-qPCR. Results. Serum concentrations of IL-1β, IL-6, IL-10, ALT, and AST and mRNA levels of TNF-α and NF-κBi were all significantly higher in septic rats than in normal rats ( p < 0.05 ). Liver GSH content was markedly lower in the CLP group than that in the sham group. βS-treated rats had remarkably lower levels of IL-1β, IL-6, IL-10, TNF-α, NF-κBi, AST, and ALT (51.79%, 62.63%, 41.46%, 54.35%, 94.37%, 95.30%, 34.87%, and 46.53% lower, respectively) and greater liver GSH content (35.71% greater) compared to the CLP group ( p < 0.05 ). Conclusion. βS may play a protective role in the septic process by mitigating inflammation. This effect is at least partly mediated by inhibition of the NF-κB signaling pathway. Thus, βS can be considered as a supplementary treatment in septic patients.

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