Chinese patent medicine for osteoporosis: a systematic review and meta-analysis

Jia, Yan; Sun, Jian; Zhao, Yan; Tang, Kaiqiang; Zhu, Ruizheng; Zhao, Wei; Wang, Rongtian; Zhang, Yanqiong; Lin, Na; Chen, Weiheng

doi:10.1080/21655979.2022.2038941

Cited by 27 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study reported that the Zuogui pill with calcium is more effective than alendronic acid with calcium or calcium alone supplement for the improvement of lumbar spines and femoral bone mineral density. The results of the bone mineral density of the current study are in line with those of systematic reviews and meta-analyses 5,16,17 . Zuogui pill increases bone density by inhibiting osteoclast activity, reducing bone calcium loss, repairing bone damage and restoration of bone structure 9 .…”

Section: Discussionsupporting

confidence: 87%

“…Zuogui pill relieves pain associated with abnormal bone metabolism in diabetic patients. The results of the pain of the current study are in line with those of systematic reviews and meta-analyses 5,16,17 and a randomized trial 19 . Improvement in skeletal deformities, joint imbalance and muscular structure tension improves pain through the Zuogui pill 12 .…”

Section: Discussionsupporting

confidence: 83%

“…Several components of the Zuogui pill have effects on hepatobiliary excretion 20 . The results of the unwanted effects of the current study are consistence with those of systematic review and meta-analyses 5,16,17 and a randomized trial 19 . Zuogui pill, alendronic acid and calcium supplements have manageable adverse effects.…”

Section: Discussionmentioning

confidence: 54%

See 2 more Smart Citations

Zuogui Pill Combined with Calcium versus Alendronate Combined with Calcium in Patients with Diabetes Induced Abnormal Bone Metabolism: An Efficacy and Safety Analysis

Jian-xiang¹,

Xia²,

Min³

et al. 2023

International J. of Pharmacology

View full text Add to dashboard Cite

Background and Objective: Calcium and vitamin D supplementation is generally the preferred treatment for abnormal bone metabolism in patients with diabetes. Alendronate is used in patients with abnormal bone metabolism but has adverse effects like headache and dizziness. Zuogui pill has established an anti-osteoporotic effect through kidney-tonifying medication. The objectives of the study were to evaluate the efficacy and safety of the Zuogui pill with calcium against daily alendronic acid with calcium and calcium alone in patients with diabetes for the management of abnormal bone metabolism. Materials and Methods: Data of demographical, clinical and pathological parameters, bone density, Visual Analog Scale (VAS) and adverse effects (9 months from start of therapy and 6 months of follow-up) of 431 patients on hypoglycemic therapy and had T-score or Z-score of lumbar spines or/and femoral bone less than -1 were collected and analyzed. Diabetic patients received 27 g Zuogui pill, 600 mg calcium carbonate and 400 IU cholecalciferol/day (ZC cohort, n = 115) or 10 mg alendronic acid, 600 mg calcium carbonate and 400 IU cholecalciferol (TC cohort, n = 135)/day or 600 mg calcium carbonate and 400 IU cholecalciferol twice in a day (CC cohort, n = 181) for 9-months. Results: After treatment (EL) T-score and Z-score of lumbar spines and femoral bone were increased in the ZC and AC cohort as compared to before treatment (p<0.05 for all). At EL T-score and Z-score of lumbar spines and femoral bone were increased for patients of the ZC cohort than those of the AC and the CC cohorts (p<0.05 for all). Only in the ZC cohort T-score and Z-score of lumbar spines bones and femoral bones of patients were increased more than -1. The VAS of patients of the ZC cohort was increased at EL than before treatment (4(2-6) vs. 3(2-5), p<0.001). Gastrointestinal discomfort, diarrhea, dizziness and fatigue were reported in the ZC cohort. Gastrointestinal discomfort, dizziness, headache, nausea, constipation, vomiting, blistering, irregular heartbeats, peeling, angioedema, numbness, difficulty with breathing, tingling effect, weight gain, hair fall, skin rash and redness of eyes with irritations were reported in the AC cohort. Conclusion: Zuogui pill with calcium effectively improves bone mineral density and pain with manageable adverse effects in diabetic patients with abnormal bone metabolism than alendronic acid with calcium or calcium alone.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Zuogui Pill Combined with Calcium versus Alendronate Combined with Calcium in Patients with Diabetes Induced Abnormal Bone Metabolism: An Efficacy and Safety Analysis

Jian-xiang¹,

Xia²,

Min³

et al. 2023

International J. of Pharmacology

View full text Add to dashboard Cite

show abstract

“…Additionally, people with OP have employed herbal monomers as additional and alternative therapies (He et al, 2014). Many recent studies have shown that herbs and many single components are effective in the treatment of OP, with the major mechanisms involving reduced oxidative stress, suppression of in ammatory response, and encouragement of osteoblastogenesis (Jia et al, 2022). Herbal polysaccharides, for example, hav e anti-osteoporosis bene ts by balancing bone resorption and bone growth (Zhang et al, 2016, Jia et al, 2022, Icariside stimulates osteogenic differentiation of mesenchymal stem cells generated from bone marrow while suppressing osteoclast differentiation and bone resorption activity to increase bone production (Lei et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate

Cai

Song

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of preosteoblastic MC3T3-E1, laying the groundwork for the treatment of osteoporosis (OP). The TCMSP database was used to find the gene targets for Res. The GeneCards database yielded the gene targets for OP. Following the discovery of potential gene targets, GO, KEGG, and Reactome enrichment analysis were conducted. Verifying the major proteins involved in apoptosis can bind to Res using molecular docking. CCK8 measured the proliferative activity of mouse preosteoblasts in each group following Res intervention. Alkaline phosphatase staining (ALP) and alizarin red staining to measure the degree of osteogenic differentiation. RT-qPCR to determine the expression levels of Runx2 and OPG genes for osteogenic differentiation ability of cells. Western blot to measure the degree of apoptosis-related protein activity in each group following Res intervention. The biological processes investigated for GO of Res therapeutic OP involved in cytokine-mediated signaling pathway, negative regulation of apoptotic process, Aging, extrinsic apoptotic signaling pathway in absence of ligand, according to potential therapeutic target enrichment study. Apoptosis, FoxO signaling pathway, and TNF signaling pathway are the primary KEGG signaling pathways. Recactome pathways are primarily engaged in Programmed Cell Death, Apoptosis, Intrinsic Apoptotic Pathway, and Caspase activation via extrinsic apoptotic signaling pathways. This research established a new approach for Res treatment of OP by demonstrating how Res controls the apoptosis-related proteins TNF, IL6, and CASP3 to suppress osteoblast death and increase osteoclastogenesis.

show abstract

“…Traditional Chinese medicine (TCM) has a long history in treating DOP and accumulated rich experience [ 14 ]. Qizhi Kebitong formula (QKF) is a classical TCM formula composed of seven TCMs, including Huang-qi ( Astragalus mongholicus Bunge, Fabaceae, root), Ji-xue-teng ( Spatholobus suberectus Dunn, Fabaceae, dry rattan stem), Huai-niu-xi ( Achyranthes bidentata Blume, Amaranthaceae, root), Sang-zhi ( Morus alba L., Moraceae, twig), Wei-ling-xian ( Clematis chinensis Osbeck, Ranunculaceae, root), Xi-xian-cao ( Sigesbeckia orientalis L., Asteraceae, aboveground part), and Quan-xie (scorpion, Buthus martensi Karsch, whole animal) in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Qizhi Kebitong Formula Ameliorates Streptozocin-Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF-κB Pathway

Tian

Ding

Wang

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Background. Diabetic osteoporosis (DOP) is a progressive osteoblast dysfunction induced by high glucose, which has negative impacts on bone homeostasis. Qizhi Kebitong formula (QKF) is a traditional Chinese medicine (TCM) formula for treating DOP. However, its role in the protection of DOP has not been clarified yet. Here, we aimed to explore the potential mechanisms of QKF on DOP development via in vivo experiment. Methods. Network pharmacology was used to detect the key targets and signaling pathways of QKF on DOP. The effects of QKF on DOP were examined by the phenotypic characteristics, micro-CT, and hematoxylin-eosin (H&E) staining. The predicted targets and pathways were validated by a streptozocin- (STZ-) induced mouse model. Subsequently, the levels of the selected genes and proteins were analyzed using qRT-PCR and Western blot. Finally, AutoDock and PyMOL were used for molecular docking. Results. In this study, 90 active compounds and 2970 related disease targets have been found through network pharmacology. And QKF could improve the microstructures of femur bone mass, reduce inflammatory cell infiltration, and downregulate the levels of TNF-α, IKBKB, IL-6, and IL-1β. Moreover, the underlying effect of PI3K/Akt/NF-κB pathways was also recommended in the treatment. Conclusion. Altogether, our findings suggested that QKF could markedly alleviate osteoblast dysfunction by modulating the key targets and PI3K/Akt/NF-κB signaling pathway.

show abstract

Chinese patent medicine for osteoporosis: a systematic review and meta-analysis

Cited by 27 publications

References 23 publications

Zuogui Pill Combined with Calcium versus Alendronate Combined with Calcium in Patients with Diabetes Induced Abnormal Bone Metabolism: An Efficacy and Safety Analysis

Zuogui Pill Combined with Calcium versus Alendronate Combined with Calcium in Patients with Diabetes Induced Abnormal Bone Metabolism: An Efficacy and Safety Analysis

Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate

Qizhi Kebitong Formula Ameliorates Streptozocin-Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF-κB Pathway

Contact Info

Product

Resources

About