Chinese medicine treatment of mastitis in COVID-19 patients

Wen, Dengpeng; Shi, Yu; Zhang, Xiaoxia; Lv, Gang

doi:10.1097/md.0000000000021656

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…[ 21 ] During the prevalence of the novel coronavirus, the clinical efficacy data of the traditional Chinese medicine showed that combining different types TCMs has the effect of reducing patient mortality and improving the treatment effect of COVID-19. [ 22 ] The XFF can reduce the infection rate of the novel coronavirus and play a preventive role. REDI can reduce the clinical symptoms of patients and has a good effect on the treatment.…”

Section: Discussionmentioning

confidence: 99%

The curative effect of Reduning injection combined with Xuanfeibaidu formula on COVID-19

Wang

Han²,

Zhang³

et al. 2020

Medicine

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Background: Since December 2019, COVID-19, caused by the new coronavirus (SARS-CoV-2), posed a serious threat to human health. On March 11, 2020, the World Health Organization announced that COVID-2019 has become a global pandemic. In China, Reduning injection (REDI) and Xuanfeibaidu formula (XFF) is widely used in treating COVID-19. However, there is no evidence-based medical evaluation that XFF combine with REDI is effective for COVID-19. Methods: The following databases will be searched: China National Knowledge Infrastructure (CNKI), Wanfang database, Chinese Science and Technology Periodical Database, Medline/PubMed, and Cochrane from October 1, 2019 to September 1, 2020. The suitable articles will be comprehensively and systematically searched without limitations of regions or language about REDI with XFF for COVID-19. The meta-analysis was performed by RevMan 5.3 and STATA 14.2 software. Results: This meta-analysis may help provide clarify on the effect of REDI combined with XFF to treat COVID-19. The result will be published at a peer-reviewed journal. Conclusions: This systematic review aims to provide new evidence of XFF combined with REDI for the treatment of COVID-19 in terms of its efficacy and safety. INPLASY registration number: INPLASY202090039.

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Section: Discussionmentioning

confidence: 99%

The curative effect of Reduning injection combined with Xuanfeibaidu formula on COVID-19

Wang

Han²,

Zhang³

et al. 2020

Medicine

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“…It is an emergent public health security event, and it not only causes physical damage to the body but also stimulates the psychological balance of the public. Recent research shows that anxiety is the highest incidence of psychological problems among the public during the epidemic, followed by depression and insomnia [ 46 , 47 ].…”

Section: Coronavirus Disease 2019 and Yin Deficiency And Internal mentioning

confidence: 99%

Insights from the Perspective of Traditional Chinese Medicine to Elucidate Association of Lily Disease and Yin Deficiency and Internal Heat of Depression

Shang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Lily disease was first recorded in Synopsis of the Golden Chamber by Zhang Zhongjing. It is a disease of heart and lung internal heat by Yin deficiency, which belongs to the category of emotion disease in Chinese medicine. In recent years, researchers believe that lily disease and depression syndrome of Yin deficiency and internal heat have many similarities in etiology, pathogenesis, and clinical manifestations. This review summarizes the clinical symptoms, etiology, pathogenesis, and therapeutic medication of lily disease and modern Yin-deficient internal heat depression and discusses the relationship between them. Furthermore, the relationship between coronavirus disease 2019 (COVID-19) and lily disease was discussed from the etiology, pathogenesis, and treatment. It provides new ideas for the treatment of COVID-19 and the treatment of psychological problems after recovery.

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“…Several plantbased therapeutic regimens have been suggested to alleviate the COVID-19 symptoms [3][4][5]. Different forms of terpenoids appear to have potential effects in inhibiting viral replication [6,7] and might be used in future investigations [8][9][10][11][12][13]. Natural products are physiologically active and as such a source of new molecular entities drugs (NMEs) [14][15][16] can be very instructive in accelerating the development of new drugs [17].…”

Section: Introductionmentioning

confidence: 99%

Discovery of Natural Products to SARS-CoV-2 with Comparative Molecular Docking and Moderate Cell Proliferation Inhibition in vitro

Yang,

Hu,

Zhu

et al. 2024

Preprint

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Based on screening in computational biology and biological in vitro assays, five natural products isolated from extracts of the herbal medicine toad skin, such as cinobufagin (CBFi), bufalin (BFi), arenobufagin (ABFi), telocinobufagin (TBFi), bufotalin (BFTi), were subjected to molecular docking calculations with the use of SARS-CoV-2 main protease (PDB 6LU7 and 7BTF) and top-scoring ligand-receptor complexes were obtained. The results showed that the binding energy of ABFi to the 3CL protein was -17.044kcal/mol, which was higher than CBFi and TBFi. However, the binding energy of ABFi to the RdRp protease was -23.250 kcal/mol, which was much lower than that of CBFi and TBFi, EVEN lower than that of ABFi to the 3CL protein. ABFi also has polar interactions with amino acids such as Glu811, Ser814, Ser681 and Thr680 of RdRp enzyme. The results revealed that ABFi had a moderate inhibitory effect on the cell proliferation of SARS-CoV-2 in vitro, with an inhibition rate of 61.12%, even weaker than Remdesivir. This new discovery provides us with new ideas for in-depth studies on the development of natural products with this class of structural generalizations as inhibitors of SARS-CoV-2, and provides an experimental basis for the next step of mechanistic studies.

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Chinese medicine treatment of mastitis in COVID-19 patients

Cited by 5 publications

References 11 publications

The curative effect of Reduning injection combined with Xuanfeibaidu formula on COVID-19

The curative effect of Reduning injection combined with Xuanfeibaidu formula on COVID-19

Insights from the Perspective of Traditional Chinese Medicine to Elucidate Association of Lily Disease and Yin Deficiency and Internal Heat of Depression

Discovery of Natural Products to SARS-CoV-2 with Comparative Molecular Docking and Moderate Cell Proliferation Inhibition in vitro

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