Chinese medicine formula Kai-Xin-San ameliorates depression-like behaviours in chronic unpredictable mild stressed mice by regulating gut microbiota-inflammation-stress system

Cao, Cheng; Liu, Mengqiu; Qu, Suchen; Ren-jie, Huang; Qi, Mingzhu; Zhu, Ziqiang; Zheng, Jing; Chen, Zhichun; Wang, Zhikang; Han, Zhengxiang; Zhu, Yue; Huang, Fei; Duan, Jin‐Ao

doi:10.1016/j.jep.2020.113055

Cited by 47 publications

(31 citation statements)

References 30 publications

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“…Notably, in other studies, KXS (0.9 or 2.7 g/kg, 5 weeks, i.g.) has also been reported to modulate the activity of the HPA axis by reversing the elevated ACTH level in CMS-induced mice [138,205]. Taken together, these studies indicate that the underlying mechanisms of KXS, as an antidepressant formula, include its actions on the neuroendocrine-immune network.…”

Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 69%

“…A chronic administration of KXS (338 or 676 mg/kg, 3 weeks, i.g.) has been shown to produce antidepressant-like activity in CUMS-induced animal models through the reduction of COX-2, IL-2, IL-6, and TNF-α expression levels and increase in IFN-γ and IL-10 production [29,138,204]. Notably, in other studies, KXS (0.9 or 2.7 g/kg, 5 weeks, i.g.)…”

Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 92%

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Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Huang

Zhang

2021

Pharmaceuticals

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The neuroimmune and neuroendocrine systems are two critical biological systems in the pathogenesis of depression. Clinical and preclinical studies have demonstrated that the activation of the neuroinflammatory response of the immune system and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis of the neuroendocrine system commonly coexist in patients with depression and that these two systems bidirectionally regulate one another through neural, immunological, and humoral intersystem interactions. The neuroendocrine-immune network poses difficulties associated with the development of antidepressant agents directed toward these biological systems for the effective treatment of depression. On the other hand, multidrug and multitarget Chinese Herbal Medicine (CHM) has great potential to assist in the development of novel medications for the systematic pharmacotherapy of depression. In this narrative essay, we conclusively analyze the mechanisms of action of CHM antidepressant constituents and formulas, specifically through the modulation of the neuroendocrine-immune network, by reviewing recent preclinical studies conducted using depressive animal models. Some CHM herbal constituents and formulas are highlighted as examples, and their mechanisms of action at both the molecular and systems levels are discussed. Furthermore, we discuss the crosstalk of these two biological systems and the systems pharmacology approach for understanding the system-wide mechanism of action of CHM on the neuroendocrine-immune network in depression treatment. The holistic, multidrug, and multitarget nature of CHM represents an excellent example of systems medicine in the effective treatment of depression.

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Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 69%

Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 92%

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Huang

Zhang

2021

Pharmaceuticals

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“… 129 In another study of CUMS-induced depression-like mice, CUMS induction resulted in increased abundance of Oscillospira , while this genus decreased after Kai-Xin-San (KXS) treatment. 131 What can be determined is that, Oscillospira is directly associated with gallstones and this organism can be used as a biomarker for symptomatic gallstone formation. 133 Keren et al found that patients with gallstones had higher total fecal bile acids (BAs) concentrations and lower microbial diversity, accompanied by increased abundance of Oscillospira , which was further analyzed and found to be positively correlated with secondary BAs and negatively correlated with primary BAs.…”

Section: Oscillospira -Related Diseasesmentioning

confidence: 99%

Oscillospira - a candidate for the next-generation probiotics

et al. 2021

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Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products.

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“…The levels of Occludin, Claudin-1, ZO-1, and IL-6 significantly reduced due to HS exposure. Previous studies have found that adding Chinese herbs to diets may reverse this adverse situation ( 18 , 56 ). The adverse effects of HS on intestinal inflammatory factors and tight junction protein were repaired by ACP and tended to return to normal levels.…”

Section: Discussionmentioning

confidence: 99%

Polysaccharides From Abrus cantoniensis Hance Modulate Intestinal Microflora and Improve Intestinal Mucosal Barrier and Liver Oxidative Damage Induced by Heat Stress

Wang

Sun

et al. 2022

Front. Vet. Sci.

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The protective effects of polysaccharides from Abrus cantoniensis Hance (ACP) on antioxidant capacity, immune function, the hypothalamus-pituitary-adrenal (HPA) axis balance, the intestinal mucosal barrier, and intestinal microflora in heat stress (HS)-induced heat-injured chickens are rarely reported. The purpose of this study was to investigate the protective effects of ACP on HS-injured chickens by enhancing antioxidant capacity and immune function, repairing the intestinal mucosal barrier, and regulating intestinal microflora. A total of 120 native roosters in Guangxi were randomly divided into 5 groups to evaluate the protective effect of ACP on chickens injured by HS (33 ± 2°C). The results showed that ACP increased the body weight and the immune organ index of heat-injured chickens, regulated the oxidative stress kinase secretion, and restored the antioxidant level of heat-injured birds. ACP significantly inhibited the secretion of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (COR) and reversed the disorder of hormone levels caused by HS. ACP significantly regulated the secretion levels of immune cytokines and restored the immune function of the body. ACP significantly improved the intestinal morphology and increased the expression levels of tight junction proteins, which had a positive effect on protecting intestinal health. The results of high-throughput sequencing of the 16S rRNA gene showed that HS led to an increase in the abundance of harmful bacteria and an abnormal increase in the abundance of intestinal microflora and that ACP restored the HS-induced intestinal microflora imbalance. In conclusion, this study provides a scientific basis for ACP as an antioxidant activity enhancer to reduce liver injury, regulate intestinal microflora, and protect intestinal mucosal damage in chickens.

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Chinese medicine formula Kai-Xin-San ameliorates depression-like behaviours in chronic unpredictable mild stressed mice by regulating gut microbiota-inflammation-stress system

Cited by 47 publications

References 30 publications

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Oscillospira - a candidate for the next-generation probiotics

Polysaccharides From Abrus cantoniensis Hance Modulate Intestinal Microflora and Improve Intestinal Mucosal Barrier and Liver Oxidative Damage Induced by Heat Stress

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