Chinese Herbs for Dementia Diseases

Abstract

In the last twenty years a considerable body of information has accumulated on the chemical constituents of Chinese herbs and their therapeutic potential. Our evaluation/systematic review [1, 2] of well-designed, randomized double blind controlled trials on Chinese herbal medicines beneficial for the improvement of cognitive function revealed a range of either single herbs or herbal mixtures that provided neuroprotective benefits. Oxidative stress may directly initiate neurodegeneration and herbal antioxidant neuroprotection is considered as a preventative and therapeutic approach. We encountered Acoris gramineus rhizome (AGR), Panax ginseng, Polygala tenuifolia and Poria cocos as the four most frequently used herbs as single/herbal mixtures that were associated with positive cognitive enhancing outcomes. This review focuses on the evidence of their medicinal effects attributed to those constituents present in relatively high concentration.

AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells

“…Chinese herbs are used for treatment of diseases in Taiwan and in China for a long time (22,23). Baicalin is one of the major flavonoids (molecular formula: C21H18O11; Fig.…”

Efficacy and safety of herbal medicine on dementia and cognitive function: An umbrella review of systematic reviews and meta‐analysis

“…We reviewed 72 full‐texts of which 37 studies were eligible including 28 systematic reviews and meta‐analyses (SR‐MA), and 9 systematic reviews. However, 13 SR‐MA were included in quantitative synthesis with 90 unique outcomes, as shown in PRISMA flowchart (Figure 1) (Ayati, Yang, Ayati, Emami, & Chang, 2020; Berthier et al, 2021; Birks & Grimley Evans, 2007, 2009; Birks, Grimley, & Van Dongen, 2002; Bosnjak Kuharic et al, 2021; Brondino et al, 2014; Chan et al, 2018; Charernboon, Lerthattasilp, & Supasitthumrong, 2021; Dong et al, 2016; Dong, Hyde, Zhang, Xue, & May, 2019; Dos Santos‐Neto, de Vilhena Toledo, Medeiros‐Souza, & de Souza, 2006; Feng et al, 2016; Fu & Li, 2011; Gauthier & Schlaefke, 2014; Geng et al, 2010; Ghassab‐Abdollahi, Mobasseri, Dehghani Ahmadabad, Nadrian, & Mirghafourvand, 2021; Ghorani‐Azam, Sepahi, Khodaverdi, & Mohajeri, 2018; Gong, Xu, & Fan, 2015; Hao, Liu, Liu, & Lv, 2009; Hashiguchi, Ohta, Shimizu, Maruyama, & Mochizuki, 2015; Huang et al, 2019; Huegel, Jackson, May, & Xue, 2012; Hyde et al, 2017; Janßen et al, 2010; Jian, Shi, Tian, & Ni, 2015; Kean, Downey, & Stough, 2016; Kim, Chang, Hong, Kim, & Koo, 2020; Kim & Cho, 2020; Kim & Kang, 2020; Kongkeaw, Dilokthornsakul, Thanarangsarit, Limpeanchob, & Scholfield, 2014; Krishnan, Cairns, & Howard, 2009; Li, Wu, Zhou, Liu, & Dong, 2008; Li, Zhao, Sun, & Kong, 2020; Liang et al, 2018; Liu, Yang, Wang, & Tian, 2013; Man et al, 2008; May et al, 2009; May et al, 2009; May et al, 2018; Miroddi et al, 2014; Ng et al, 2020; Pase et al, 2012; Perng, Chang, & Tzang, 2018; Pitkala, Suominen, Bell, & Strandberg, 2016; Puttarak et al, 2017; Qin...…”

Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy

“…23,91,92 Understanding the effects and underlying mechanisms of polyphenols within the human organism, and their clinical outcome in human diseases, remains a matter of controversy in nutrition science and disease prevention. Despite this, and based on strong experimental support, polyphenols may be beneficial (but not limited to) in the prevention and treatment of cancer, 7,8 neuroprotection, and neurodegeneration-related pathologies, 93,94 cardiovascular dysfuction and damage, 95,96 metabolic syndrome, 97,98 diabetes, 99 aging, 100,101 and inflammation-related diseases. 102−104 ■ ANTITUMOR PROPERTIES AND PROPOSED MECHANISMS At present there is abundant information regarding cellular mechanisms by which polyphenols may affect carcinogenesis, 105 tumor cell proliferation and death, 7 inflammation, 104 angiogenesis, 106 dissemination, 7 and drug and radiation resistance.…”