Chinese herbal medicines for treating diabetic foot ulcers

Liu, Jianping; Zhang, Jing; Lü, Hao; Bell-Syer, Sally EM

doi:10.1002/14651858.cd006098

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…We found systematic reviews on diabetic foot, chronic wounds and S. aureus colonization with conclusive results, [18][19][20][21][22][23][24][25][26][27] but no reviews reporting the healing of wounds infected with S. aureus, in diabetic patients.…”

Section: Resultsmentioning

confidence: 93%

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Interventions for wound healing among diabetic patients infected with Staphylococcus aureus: a systematic review

et al. 2011

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CONTEXT AND OBJECTIVE: Staphylococcus aureus is the most frequent agent isolated in diabetic foot infections and may be associated with changes to wound healing times. The aim of this study was to perform a systematic review of the literature, including studies that assessed the efficacy of any clinical or surgical intervention, as well as oral or topical therapy for diabetic ulcers infected with S. aureus. DESIGN AND SETTING:Systematic review with a search conducted in databases. METHODS:We conducted a systematic review with a comprehensive search in the Lilacs, SciELO, PubMed/Medline, Old Medline, Embase and Cochrane Library databases, for articles published from 1966 to 2010. The articles selected were limited to studies on diabetic patients with wounds infected with S. aureus for whom their healing was followed up, with the use of either antibiotics or experimental treatments. Animal studies and those that did not report the wound healing, as well as review articles, were excluded. RESULTS:Five studies that met the inclusion and exclusion criteria were analyzed. CONCLUSIONS:There are few studies reporting the healing of wounds infected with S. aureus in diabetic patients, although this is the most commonly found pathogen in this type of wound and it frequently consists of methicillin-resistant S. aureus (MRSA). There is insufficient evidence to support early use of broad-spectrum antibiotics against MRSA to promote healing of diabetic ulcers, since antibiotic resistance may develop from such treatment.This highlights the need for further studies on the subject. RESUMOCONTEXTO: Staphylococcus aureus é o agente mais frequentemente isolado nas infecções de pé em pacientes diabéticos e pode estar associado a mudança no tempo de cicatrização de feridas. O objetivo deste estudo foi realizar uma revisão sistemática da literatura, incluindo estudos que avaliaram a eficácia de qualquer intervenção clínica, cirúrgica, bem como terapia oral ou tópica para o tratamento de úlceras diabéticas infectadas com o S. aureus. TIPO DE ESTUDO E LOCAL:Revisão sistemática com busca realizada em bancos de dados. MÉTODOS:Realizamos uma revisão sistemática com uma busca abrangente nos bancos de dados Lilacs, SciELO, PubMed/Medline, Old Medline, Embase e no banco de dados da biblioteca Cochrane, publicados entre 1966 e 2010. Os artigos selecionados foram limitados aos estudos com feridas infectadas por S. aureus de pacientes diabéticos, que tiveram cicatrização relatada, quer pela utilização de antibióticos ou por substâncias experimentais. Foram excluídos os estudos com animais e os que não relataram a cicatrização das feridas, bem como artigos de revisão. RESULTADOS:Foram analisados cinco estudos que obedeceram aos critérios de inclusão e exclusão.CONCLUSÕES: Raros estudos relataram cicatrização de feridas infectadas com S. aureus em pacientes diabéticos, embora este seja o patógeno mais comumente encontrado neste tipo de ferida, sendo frequentemente resistente à meticilina MRSA (methicillin-resistant S. aureus). Não há evidê...

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Section: Resultsmentioning

confidence: 93%

“…We did not find any systematic review that was similar to what has been presented here. We found systematic reviews on diabetic foot, chronic wounds and S. aureus colonization with conclusive results, 18 - 27 but no reviews reporting the healing of wounds infected with S. aureus , in diabetic patients.…”

Section: Discussionmentioning

confidence: 91%

Interventions for wound healing among diabetic patients infected with Staphylococcus aureus: a systematic review

et al. 2011

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Diabetes and complementary therapies: mapping the evidence

et al. 2007

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Complementary therapies are widely used by people with diabetes for the condition itself, for diabetes‐related complications or for non‐diabetes related problems. The aim of this review is to summarise the current research evidence on complementary therapies in the management of diabetes and resulting complications.The review draws primarily on systematic reviews conducted as part of the CAMEOL project (www.rccm.org.uk/cameol), included in the Cochrane Library or on the National Library for Health Complementary and Alternative Medicine Specialist Library (www.library.nhs.uk/cam). Searches were also carried out for studies published subsequently or on other therapies to provide an indication of overall research activity.Systematic reviews were found or conducted on a range of herbs, dietary supplements, massage, acupuncture, homoeopathy, hypnotherapy, meditation, reflexology and yoga. Individual studies were located on several other therapies. Studies addressed metabolic control, general well‐being and complications. Herbs and dietary supplements continue to be the main focus of research activity. Acupuncture trials are also numerous but almost exclusively conducted in China using traditional approaches. For most other therapies, research evidence is limited by extent or quality.Overall, limited data from well‐designed randomised controlled trials are available and results are difficult to translate into clinical practice. Based on promising findings, several herbs, dietary supplements, exercise or body‐based therapies and acupuncture require further investigation. For most therapies, well‐designed robust studies replicating small preliminary studies are required to support those involved in diabetes care in providing evidence‐based advice on the safe and effective use of complementary therapies. Copyright © 2007 John Wiley & Sons.

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Effectiveness of Individual-Level Interventions to Prevent Vascular Complications

Adler¹

2010

Diabetes Public Health

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This chapter covers interventional studies aimed at lowering the incidence of cardiovascular disease (CVD), nephropathy, retinopathy, blindness, lower-extremity amputation (LEA), peripheral sensory neuropathy, and autonomic neuropathy; and at prolonging life. It includes studies that address clinical endpoints. It shows that individuals with diabetes and their providers of care can reduce the occurrence of diabetic complications by lowering glucose, blood pressure, and LDL, either alone or in combination. Nonpharmacologic interventions, chiefly those related to retinopathy and obesity, also improve outcomes. To date evidence for lowering blood glucose and blood pressure does not support the use of specific agents except possibly metformin and blockade of the angiotensin system. For LDL, statins remain the intervention of choice.

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Chinese herbal medicines for treating diabetic foot ulcers

Cited by 3 publications

References 17 publications

Interventions for wound healing among diabetic patients infected with Staphylococcus aureus: a systematic review

Interventions for wound healing among diabetic patients infected with Staphylococcus aureus: a systematic review

Diabetes and complementary therapies: mapping the evidence

Effectiveness of Individual-Level Interventions to Prevent Vascular Complications

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