Chinese herbal medicines for the treatment of cough in idiopathic pulmonary fibrosis

Xiao, Siyao; Yang, Yu; Xiong, Yimin; Sun, Fang; Liu, Xiaoyu; Yan, Jiaxin; Zhang, Shunan

doi:10.1097/md.0000000000022991

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…9 Metaanalysis revealed that combination treatment of herbal medicines and pirfenidone significantly improved cough and enhanced the quality of life in patients with PF. 10 Furthermore, natural products such as isoglycyrrhizin 11 and quercetin 12 have been demonstrated with protective effects on bleomycin (BLM)-induced PF model. Elucidating the protective mechanisms of natural products on PF can contribute to their clinical application.…”

Section: Introductionmentioning

confidence: 99%

Peimine Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice Through Reducing Epithelial-Mesenchymal Transition, Inflammation and Oxidative Stress and Regulating Host Metabolism

Li,

Zhang,

Shen

et al. 2023

Natural Product Communications

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Objectives Peimine (PM), derived from Fritillaria thunbergii Miq, has been demonstrated with protective effects on pulmonary fibrosis (PF). However, the detailed mechanisms of PM on PF remain unknown. The aim of current study was to assess the therapeutic effects and the possible mechanism of PM on PF. Methods In this study, mice received bleomycin (BLM) injection to induce PF and then received the treatment of PM orally. The therapeutic effects of PM on PF were firstly assessed through histopathological staining (hematoxylin and eosin and Masson staining) and measuring hydroxyproline (HYP) level in lung. Then, we measured the levels of epithelial-mesenchymal transition (EMT)-related markers (vimentin and E-cadherin), pro-inflammatory factors (interleukin [IL]-1β, IL-6, and tumor necrosis factor alpha [TNF-α]), and oxidative stress-related indicators (superoxide dismutase[SOD], malondialdehyde [MDA] and glutathione peroxidase [GSH-Px]) in lung. Furthermore, untargeted metabolomics were employed to explore the effects of PM on metabolites in lung. Results PM treatment improved the pathological changes including reducing the infiltration of inflammatory cells and decreasing collagen deposition, and decreasing the HYP level in lung in PF mice. Moreover, PM treatment up-regulated E-cadherin and down-regulated vimentin, decreased IL-1β, IL-6 and TNF-α expression, increased SOD and GSH-Px activities, and decreased MDA level in lung. Untargeted metabolomics analysis showed that PM altered the metabolites in lung of mice with BLM-induced PF. The differential metabolites were mainly associated with tryptophan metabolism, nicotinate and nicotinamide metabolism, alanine, aspartate and glutamate metabolism, arginine biosynthesis, and D-glutamine and D-glutamate metabolism. Conclusion PM exhibited therapeutic effects on BLM-induced PF mice including reducing collagen deposition, inhibiting EMT and reducing inflammation and oxidative stress. The mechanism of PM on PF may be associated with regulating tryptophan metabolism, nicotinate and nicotinamide metabolism, alanine, aspartate and glutamate metabolism, arginine biosynthesis, and D-glutamine and D-glutamate metabolism in lung.

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Section: Introductionmentioning

confidence: 99%

Peimine Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice Through Reducing Epithelial-Mesenchymal Transition, Inflammation and Oxidative Stress and Regulating Host Metabolism

Li,

Zhang,

Shen

et al. 2023

Natural Product Communications

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Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

Tang

Liang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. There is no effective therapy for silicosis, and Dahuang Zhechong pill (DHZCP), an ancient Chinese medicine prescription, may have a therapeutic effect on silicosis. This study aims to verify the efficacy and safety of DHZCP in silicosis. Methods. This is a randomized controlled clinical trial done at Panzhihua Second People’s Hospital (Panzhihua City, Sichuan Province, China). Participants diagnosed with silicosis were recruited and randomized to the conventional treatment group (CG) or DHZCP combined with the conventional treatment group (DG). Forced vital capacity % predicted (FVC%), diffusing capacity of the lung for carbon monoxide % predicted (DLCO%), six-minute walk distance (6MWD), peripheral oxygen (SpO2), King’s Brief Interstitial Lung Disease Questionnaire (K-BILD), and safety outcomes were measured at baseline and 9 weeks. Results. Fifty-six participants (28 in each group) completed the study, and 53 of them (26 in DG and 27 in CG) completed pulmonary function. At 9 weeks, compared with no DHZCP, DHZCP treatment was associated with significant improvements in FVC% (mean ± SD, 95%CI) (8.2 ± 3.9, 0.3 to 16.0), DLCO% (8.6 ± 3.5, 1.5 to 15.7), SpO2 (3.8 ± 0.7, 2.3 to 5.2), and K-BILD total score (6.0 ± 2.3, 1.4 to 10.7). And, there were no statistical differences of safety outcomes between the two groups. Eight patients accepting DHZCP developed mild diarrhea during the first week, which subsequently resolved on its own. Conclusion. DHZCP could improve the pulmonary function, the quality of life, and the exercise capacity of silicosis patients.

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Chinese herbal medicines for the treatment of cough in idiopathic pulmonary fibrosis

Cited by 2 publications

References 26 publications

Peimine Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice Through Reducing Epithelial-Mesenchymal Transition, Inflammation and Oxidative Stress and Regulating Host Metabolism

Peimine Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice Through Reducing Epithelial-Mesenchymal Transition, Inflammation and Oxidative Stress and Regulating Host Metabolism

Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

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