Chinese herbal medicine Wutou decoction for knee osteoarthritis

Abstract

Background: Knee osteoarthritis (KOA) causes joint pain and limited mobility, which affects the quality of life. The use of Chinese herbal medicine to treat KOA has achieved certain effects, and Wutou decoction (WTD) is one of them. But there is no high-level evidence to support this result. The purpose of this work is to evaluate WTD's efficacy and safety in the management of KOA. Methods: We will search articles in 7 electronic databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang Data (WF), Chinese Scientific Journals Database (VIP), Chinese databases SinoMed (CBM), PubMed, Embase, and Cochrane Library databases. All the publications, with no time restrictions, will be searched without any restriction of language and status, the time from the establishment of the database to September 2020. Two reviewers will independently assess the quality of the selected studies, NoteExpress and Excel software will be used to extract data, and the content will be stored in an electronic chart. Different researchers will separately screen the titles and abstracts of records acquired potential eligibility which comes from the electronic databases. Full-text screening and data extraction will be conducted afterward independently. Statistical analysis will be conducted using RevMan 5.4 software. Results: This study will evaluate the current efficacy and safety of WTD in the treatment of KOA, to provide high-quality, evidence-based clinical recommendations. Conclusion: This study will provide reliable evidence on whether WTD is safe and effective in treating KOA. Trial registration number: INPLASY202090022

A multi-center clinical study on the treatment of knee osteoarthritis with Qubi Yangge Decoction combined with three steps and nine methods of whole knee

“…The WOMAC sub-scales assess the dimensions of pain, functionality, and joint stiffness using 24 questions (rated 0-100 on a VAS). It has been subjected to numerous validation studies and was successfully used in the pilot study [19] and in dose-optimization studies [35] . The minimal clinically signi cant difference in the total WOMAC score has been reported to be a 12% or 16% improvement from baseline [36] .…”

“…KOA belongs to the category of "Impediment disease" in traditional Chinese medicine (TCM), and the comprehensive treatment of TCM using this modality has certain advantages [18][19] . Basic research has shown that TCMs affect the function of chondrocytes, protect their structure, inhibit matrix-degrading enzymes, reduce the concentrations of pro-in ammatory factors in the knee joint, and inhibit synovial in ammation, thereby alleviating joint pain and improving function [20][21][22][23] .…”

Deep Learning-Based CT Imaging to Evaluate the Therapeutic Effects of Acupuncture and Moxibustion Therapy on Knee Osteoarthritis

“…Knee pain is due to liver and kidney impairment caused by cold and dampness [ 16 ]. The symptoms of joint pain described in the classic literature are consistent with KOA symptoms, including knee swelling [ 17 , 18 ]. The application of acupuncture has a long clinical history in the treatment of bone diseases [ 19 ].…”