Chinese herbal medicine for subfertile women with polycystic ovarian syndrome

Zhang, Jing; Li, Tingting; Zhou, Lingling; Tang, Liulin; Xu, Liangzhi; Wu, Taixiang; Lim, Danforn CE

doi:10.1002/14651858.cd007535.pub2

Cited by 25 publications

(22 citation statements)

References 30 publications

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“…Therefore, the effective treatment of adolescent PCOS is of particular importance (8). However, the effectiveness of pure Western or traditional Chinese medicine (TCM) treatment in adolescent PCOS has not been satisfactory (9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Bak Foong pills combined with metformin in the treatment of a polycystic ovarian syndrome rat model

Liu

et al. 2015

Oncology Letters

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Abstract. The aim of the present study was to investigate the treatment effects and associated mechanism of Bak Foong pills (BFPs) combined with metformin in the treatment of polycystic ovarian syndrome (PCOS). BFPs and/or metformin were administrated to treat the PCOS rats, and the weights and morphologies of the ovary, uterus and adrenal gland were measured. The levels of fasting blood glucose (FBG), serum testosterone (T), luteinizing hormone, fasting insulin (FIN) and insulin-like growth factor-1 were also measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. The expression level of androgen receptor (AR) in the ovarian tissue, and the cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) mRNA levels in the ovary and adrenal tissues were detected. The levels of T, FIN, FBG and HOMA-IR in the combination group were significantly reduced; the wet weights of the ovary and the adrenal gland were decreased significantly, while that of the uterus was increased, and the histological morphology benignly recovered. The rats of each treatment group all experienced restored ovulation. The AR expression level in the treatment group was reduced, and the P450scc mRNA levels in the ovary and the adrenal gland of the combined treatment group were decreased. BFPs combined with metformin significantly affected PCOS, and the possible mechanism involved in the treatment may have been through the reduction of P450scc generation. BFPs may reduce the androgen levels, thus allowing the ovary to restore ovulation.

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Section: Introductionmentioning

confidence: 99%

Bak Foong pills combined with metformin in the treatment of a polycystic ovarian syndrome rat model

Liu

et al. 2015

Oncology Letters

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“…For example the RCT interventions described in a Cochrane review for PCOS-related subfertility focused on diagnostic patterns of Kidney yang deficiency and Spleen Qi deficiency. 10 Although these were reported in our guidelines, other patterns were also identified such as Excess Cold in the Uterus and Blood deficiency that were not reported in the RCTs. This may be because these patterns occur more frequently in oligo-and amenorrhoea than in subfertility or because these patterns do not occur sufficiently frequently in the PCOS population to warrant investigation in RCTs.…”

Section: Discussionmentioning

confidence: 78%

“…9 However, many of these RCTs have been conducted in China and are methodologically poor thus limiting the generalisability of these findings. 10 This necessitates further exploration of the effects of CHM with a fully-powered RCT in the UK. It is important however to ensure such a study is relevant to CHM practice in Western countries such as the UK, and that it takes into consideration characteristics of good clinical practice as determined by CHM practitioners.…”

Section: Introductionmentioning

confidence: 99%

Developing clinical practice guidelines for Chinese herbal treatment of polycystic ovary syndrome: A mixed-methods modified Delphi study

Lai¹,

Flower²,

Moore³

et al. 2015

Complementary Therapies in Medicine

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SummaryObjectives: Preliminary evidence suggests Chinese herbal medicine (CHM) could be a viable treatment option for polycystic ovary syndrome (PCOS). Prior to conducting a clinical trial it is important to consider the characteristics of good clinical practice. This study aims to use professional consensus to establish good clinical practice guidelines for the CHM treatment of PCOS. Design and setting: CHM practitioners participated in a mixed-methods modified Delphi study involving three rounds of structured group communication. Round 1 involved qualitative interviews with practitioners to generate statements regarding good clinical practice. In round 2, these statements were distributed online to the same practitioners to rate their agreement using a 7-point Likert scale, where group consensus was defined as a median rating of ≥5. Statements reaching consensus were accepted for consideration onto the guideline whilst those not reaching consensus were re-distributed for consideration in round 3. Statements presented in the guidelines were graded from A (strong consensus) to D (no consensus) determined by median score and interquartile range. Results: 11 CHM practitioners in the UK were recruited. After three Delphi rounds, 91 statement items in total had been considered, of which 89 (97.8%) reached consensus and 2 (2.2%) did not. The concluding set of guidelines consists of 85 items representing key features of CHM prescribing for PCOS. Conclusions: These guidelines can be viewed as an initial framework that captures fundamental principles of good clinical practice for CHM.

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“…Producing high quality herbal research is challenging due to the lack of uniformity in herbal prescriptions and additionally, sourcing funding. Chinese herbal medicine (CHM) has benefitted from more robust scientific interest, in particular with PCOS related infertility (Zhang et al 2010, Kuek at al. 2011).…”

Section: Herbal Medicine and Pcosmentioning

confidence: 99%

Phytotherapy for Polycystic Ovarian Syndrome: A review of the literature and evaluation of practitioners’ experiences

Rooney

Pendry

2014

Journal of Herbal Medicine

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Chinese herbal medicine for subfertile women with polycystic ovarian syndrome

Abstract: There is limited evidence that the addition of CHM to clomiphene is associated with improved clinical pregnancy outcomes and no other evidence of any other effect. The methodology of RCTs was not adequately reported by primary studies.

Cited by 25 publications

References 30 publications

Bak Foong pills combined with metformin in the treatment of a polycystic ovarian syndrome rat model

Bak Foong pills combined with metformin in the treatment of a polycystic ovarian syndrome rat model

Developing clinical practice guidelines for Chinese herbal treatment of polycystic ovary syndrome: A mixed-methods modified Delphi study

Phytotherapy for Polycystic Ovarian Syndrome: A review of the literature and evaluation of practitioners’ experiences

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