Chinese Herbal Medicine for Functional Dyspepsia With Psychological Disorders: A Systematic Review and Meta-Analysis

Luo, Xiaoying; Wang, Lin; Fang, Shuangshuang; Qing, Xiangli; Jiang, Tianyuan; Yang, Yang; Xiaolan, Su; Wei, Wei

doi:10.3389/fnins.2022.933290

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…This study presents the first systematic meta-analysis that evaluates the efficacy of acupuncture in treating FD accompanied by symptoms of depression and anxiety. Although previous meta-analyses have confirmed the effectiveness of Chinese Herbal Medicine in traditional Chinese medicine for treating FD with psychological conditions [ 47 ], no comparable systematic evaluations exist for acupuncture. To bridge this gap, we used various validated scales to measure the severity of depression and anxiety in patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of acupuncture for anxiety and depression in functional dyspepsia: A systematic review and meta-analysis

Xu,

Zhang,

Shi

et al. 2024

PLoS ONE

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Objective To assess the effectiveness of acupuncture for treating depression and anxiety in patients diagnosed with functional dyspepsia (FD). Methods PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang Data, Sinomed, and VIP Database were searched until April 30, 2023 for Randomized Controlled Trials (RCTs) comparing acupuncture to placebo or drugs for symptom alleviation. Two independent reviewers conducted the study search, data extraction, and bias risk assessment using the Cochrane Risk of Bias tool. Mean difference (MD), risk ratio (RR), and corresponding 95% confidence intervals (CI) were computed. Subgroup and sensitivity analyses were also performed. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was employed to evaluate the evidence level. Results A total of 16 RCTs involving 1315 participants were included. Acupuncture demonstrated marked superiority over placebo (MD = -7.07, 95%CI: -11.03 to -3.10, very low quality evidence) in mitigating Self-Rating Anxiety Scale (SAS) scores and was found to be more effective in reducing Self-Rating Depression Scale (SDS) scores than either placebo (MD = -4.63, 95%CI: -6.28 to -2.98, low quality evidence) or first-line drugs (MD = -2.71, 95%CI: -5.19 to -0.23, very low quality evidence). In terms of attenuating Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) scores, acupuncture consistently outperformed both placebo (HAMA: MD = -2.58, 95%CI: -4.33 to -0.83, very low quality evidence; HAMD: MD = -1.89, 95%CI: -3.11 to -0.67, low quality evidence) and first-line drugs (HAMA: MD = -5.76, 95%CI: -10.18 to -1.35, very low quality evidence; HAMD: MD = -5.59, 95%CI: -7.59 to -3.59, very low quality evidence). However, no significant difference was observed between acupuncture and placebo in terms of improvement in Hospital Anxiety and Depression Scale (HADS) scores. Conclusions Based on current clinical evidence, acupuncture might have a positive effect on depression and anxiety in patients with FD. Further large-sample, multi-center, high-quality RCTs validation are required, as the conclusion is limited by the quantity and quality of the included studies.

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Section: Discussionmentioning

confidence: 99%

Efficacy of acupuncture for anxiety and depression in functional dyspepsia: A systematic review and meta-analysis

Xu,

Zhang,

Shi

et al. 2024

PLoS ONE

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“…When individuals experience FGIDs, they tend to also experience anxiety reactions. This is so recurrent that it is challenging to stop the cycle of problems between psychological and physical disorders[ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a form of reciprocity, studies have shown that the incidence of psychological disorders in patients with FGIDs is significantly higher than in non-FGID patients; symptoms of FGIDs are strongly associated with mental health disorders, especially anxiety and depression [ 49 , 50 ]. Pathophysiological studies of FGIDs have shown that psychosocial factors can influence FGIDs by regulating processing pathways and decreasing visceral signaling in the brain [ 29 , 32 ]. Analyses of interventions for irritable bowel syndrome have shown that psychological interventions, including web-based CBT, could treat irritable bowel syndrome effectively in patients [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Cognitive Behavioral Therapy With Local Wisdom and Web-Based Counseling on Generalized Anxiety Disorders and Functional Gastrointestinal Disorders in Adolescent College Girls: Protocol for a Randomized Controlled Trial

Ardi,

Eseadi,

Yuniarti

et al. 2023

JMIR Res Protoc

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Background The high academic demands experienced by students will often have an impact on the quality of their mental and physical health. The most common health problems reported are gastrointestinal disorders. This condition tends to manifest in the emergence of generalized anxiety disorders (GADs) and reduces the quality of life and productivity. The population that experiences this disorder the most is female adolescents, and this condition occurs in both South African and Indonesian populations. The use of drugs, especially benzodiazepines, often causes psychological conditions as side effects. For this reason, it is necessary to have a solution in the form of a targeted and efficient approach to reduce psychological symptoms that arise from functional gastrointestinal disorders (FGIDs) in the form of anxiety. Objective The purpose of this study is to produce and implement a counseling intervention model to assist female students with GADs caused by FGID factors using an approach combining cognitive behavioral therapy (CBT), web-based counseling, and local wisdom in Indonesian and South African populations. Methods The research subjects will comprise 118 female adolescent students from Indonesia and 118 female adolescent students from South Africa, making a total sample of 236 participants, and the study will use a prospective, parallel randomized controlled trial design. The recruitment process will begin in July 2023, and the trial will begin in August 2023. The posttest assessment data gathering will take place by November 2023. Questionnaires that will be used in this study include the Functional Gastrointestinal Disorder Checklist (FGI-Checklist) to collect data related to FGIDs and the Generalized Anxiety Disorder 7-item (GAD-7) to measure the anxiety conditions experienced by respondents. Results By adopting the intention-to-treat principle, there will be significant mean changes in GAD scores and FGID scores after exposure to this combined approach in the Indonesian and South African populations. Implementing this comprehensive intervention will improve the students’ psychological symptoms related to FGIDs and ultimately enhance their overall well-being. Conclusions This study will develop and implement a model of counseling intervention for female students with GADs obtained from FGIDs using a combination approach to CBT, web-based counseling, and local wisdom in both the Indonesian and South African populations. The trial findings will contribute to our understanding of the effects of CBT combined with local wisdom and web-based counseling approaches that mental health counselors can use to treat GAD-affected adolescent girls who have FGIDs. Trial Registration UMIN Clinical Trial Registry UMIN000051386; https://tinyurl.com/yjwz8kht International Registered Report Identifier (IRRID) PRR1-10.2196/50316

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“…Chinese herbal medicine (CHM) has a long history and rich experience in CG treatment. CHM can regulate the functions of the stomach and spleen, harmonize the liver and stomach, eliminate dampness and heat, promote blood circulation, and eliminate blood stasis[ 6 ]. CHM can also modulate the immune system, inhibit the growth of H. pylori , protect the gastric mucosa, and improve the quality of life of patients with CG[ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical study on microscopic syndrome differentiation and traditional Chinese medicine treatment for liver stomach disharmony in chronic gastritis

Bai,

Tian,

Zhang

2024

World J Gastrointest Surg

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BACKGROUND Chronic gastritis (CG) is a common gastrointestinal disorder characterized by inflammation of the stomach lining. Liver-stomach disharmony (LSD) syndrome is believed to contribute to CG symptoms. AIM To evaluate the efficacy and safety of microcosmic syndrome differentiation and Chinese herbal medicine (CHM) treatment in patients with CG and LSD syndrome. METHODS Sixty-four patients with CG and LSD syndrome were randomly divided into two groups: The treatment group received CHM based on microcosmic syndrome differentiation and the control group received conventional Western medicine. The treatment course lasted 12 wk. The primary outcome was improvement in dyspeptic symptoms, measured using the Nepean Dyspepsia Index. The secondary outcomes included the improvement rate of endoscopic findings, histopathological findings, and microcosmic syndrome scores and the incidence of adverse events. RESULTS After 12 wk of treatment, the treatment group showed significantly greater improvement in dyspeptic symptoms than the control group (93.75% vs 65.63%, P < 0.01). The treatment group also showed a significantly higher improvement rate in endoscopic findings than the control group (81.25% vs 53.13%, P < 0.05). The improvement rates of histopathological findings and microcosmic syndrome scores were not significantly different between the two groups (P > 0.05). No serious adverse events were observed in either group. CONCLUSION Microcosmic syndrome differentiation and CHM treatment can effectively improve dyspeptic symptoms and endoscopic findings in patients with CG and LSD syndrome and have a good safety profile. Further studies with larger sample sizes and longer follow-up periods are required to confirm the long-term efficacy and mechanism of action of this treatment.

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Chinese Herbal Medicine for Functional Dyspepsia With Psychological Disorders: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 28 publications

Efficacy of acupuncture for anxiety and depression in functional dyspepsia: A systematic review and meta-analysis

Efficacy of acupuncture for anxiety and depression in functional dyspepsia: A systematic review and meta-analysis

Efficacy of Cognitive Behavioral Therapy With Local Wisdom and Web-Based Counseling on Generalized Anxiety Disorders and Functional Gastrointestinal Disorders in Adolescent College Girls: Protocol for a Randomized Controlled Trial

Clinical study on microscopic syndrome differentiation and traditional Chinese medicine treatment for liver stomach disharmony in chronic gastritis

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