Chinese herbal medicine for atopic eczema

Zhang, Weiya; Leonard, Tina; Bath‐Hextall, Fiona; Chambers, C.; Lee, Chuanfang; Humphreys, Rosemary; Williams, Hywel C

doi:10.1002/14651858.cd002291.pub4

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…Indeed, alternative/complementary therapies for AD, such as Chinese herbal therapy, have become increasingly popular. [50][51][52] Demographic characteristics of patients Many of the participants in the included studies were female.…”

Section: Qol and Patients With Ad Compared To Other Chronic Skin Condmentioning

confidence: 99%

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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Atopic dermatitis (AD) can affect quality of life (QoL) of adult patients in whom the condition can be severe and persistent. There are currently no systematic reviews of the impact of AD on adults. This paper provides the first systematic literature review and meta‐analysis of the impact of AD on QoL in adults. A systematic search was conducted using MEDLINE, Scopus, and Web of Science for articles published until October 2018. Inclusion criteria were a clinical diagnosis of AD, adult patients, and QoL as an outcome measure. Interventions were excluded. A total of 32 studies were included. While QoL was assessed using Dermatology Life Quality Index (DLQI) in 25 studies, there was heterogeneity in the tools used to measure disease severity across studies. Meta‐analysis of the seven studies that used the SCORAD to measure disease severity showed severity to be significantly related to poorer QoL. The remaining 18 studies also showed increased disease severity significantly related to poorer QoL. When compared to healthy controls, AD patients demonstrated significantly lower QoL, but findings were mixed in studies that compared QoL in AD to other skin conditions. The findings highlight the significant impact that AD has on QoL in adults and the need for validated and relevant QoL measures to be implemented in clinical assessments for AD. Areas that require further research include an exploration of gender differences in QoL and the use of longitudinal study designs to explore factors that may cause differences in QoL ratings.

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Section: Qol and Patients With Ad Compared To Other Chronic Skin Condmentioning

confidence: 99%

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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“…The severity of eruptions on lesions is evaluated on a 4-point scale (0: none, 1: mild, 2: moderate, 3: severe) by scoring the erythema, oedema, oozing, excoriation, lichenification, and xerosis. SCORAD is calculated by the equation A/5 + 7 × B/2 + C. In this equation, A is the percentage of body area with a skin rash, B is the total score of erythema, oedema, oozing, excoriation, lichenification, and xerosis, each of which was evaluated on a 4-point scale, and C is the visual analogue scale (VAS, a scale from 0 to 10) for subjective assessment of both itching and sleep loss[ 18 - 20 ]. It will be measured at treatment initiation, at two weeks after the first medication administration, at four weeks after the first medication administration, and at eight weeks after the first medication administration.…”

Section: Methodsmentioning

confidence: 99%

Hwangryunhaedoktang in adult patients with Atopic Dermatitis: a randomised, double-blind, placebo-controlled, two-centre trial - study protocol

Kim

Lee

Seo

et al. 2011

BMC Complement Altern Med

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BackgroundAtopic Dermatitis is a chronic relapsing eczematous skin disease with increasing prevalence and rising costs. It has a clear impact on a patient's quality of life. Many patients are worried about the use of usual care techniques, such as corticosteroids and antihistamine due to the widespread fear of adverse effects. Complementary and alternative medical approaches have been employed to relieve symptoms of Atopic Dermatitis. Hwangryunhaedoktang is among the most strongly preferred and widely used herbal medicines for Atopic Dermatitis in Korea, as it causes very few serious adverse effects.We aim to establish basic clinical efficacy and safety data for Hwangryunhaedoktang, which is approved as an herbal medication by the Korean Food and Drug Administration, in adult patients with Atopic Dermatitis.Methods/DesignsThis study is a randomised, double blind, placebo-controlled, two-centre trial with two parallel arms (Hwangryunhaedoktang and a placebo). The diagnosis of Atopic Dermatitis will be made according to the criteria of Hanifin and Rajka by two different Oriental medicine doctors. We will include participants experiencing typical conditions of intermittent or continuous Atopic Eczema for six or more months. Participants will receive Hwangryunhaedoktang or a placebo-drug for eight weeks. The total duration of each arm is eleven weeks. Each participant will be examined for signs and symptoms of Atopic Dermatitis before and after taking medication. A follow-up to evaluate the maintenance of safety will be performed two weeks after the final administration of medication.DiscussionThis trial will utilize high quality trial methodologies in accordance with consolidated standards of reporting trials guidelines. It will provide evidence for the clinical efficacy and safety evaluation of Hwangryunhaedoktang in adult patients with Atopic Dermatitis. Moreover, we will also employ health-related quality of life questionnaires to assess the changes in quality of life.Trial registrationCurrent Controlled Trials ISRCTN26218532

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“…Further double-blind RCTs with 1 year follow-ups showed specific effects regarding itch intensity and skin condition in AD patients for a herb mixture (Zemaphyte) consisting of Potentilla chinensis, Tribulus terrestris, Rehmannia glutinosa, Lophaterum gracile, Clematis armandii, Ledebouriella seseloides, Dictamnus dasycarpus, Paeonia lactiflora, Schizonepeta tenuifolia, and Glycyrrhica glabra (45)(46)(47)(48)(49)(50)(51). Experimental studies on the possible mechanisms showed a change in immune response (e.g.…”

Section: Phytotherpapy Oral Administrationmentioning

confidence: 99%

“…However, during intake liver function parameters should be monitored, as liver function abnormalities were observed in several cases. These abnormalities disappeared after stopping the herbal therapy (51). Finally, studies on a herb mixture consisting of five herbs (2 g Flos lonicerae, 1 g Herba menthae, 2 g Cortex moutan, 2 g Rhizoma atractylodis, and 2 g Cortex phellodendri) that were certified as steroid-free (53)(54)(55)(56) showed efficacy in children as well as adults with AD.…”

Section: Phytotherpapy Oral Administrationmentioning

confidence: 99%

Complementary integrative approach for treating pruritus

et al. 2013

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Complementary and alternative medicine (CAM) is a conservative and increasingly popular approach to treat pruritus for both patients and medical providers. CAM includes natural products, mind-body medicine, and manipulative and body-based practices. In this overview, we summarize current evidence, possible mechanisms and clinical approaches for treating pruritus with CAM techniques. We focus on pruritus associated with atopic dermatitis, herpes zoster, chronic urticaria, burns, and postoperative contexts where the evidence for CAM approaches is promising.

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Chinese herbal medicine for atopic eczema

Cited by 16 publications

References 31 publications

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

Hwangryunhaedoktang in adult patients with Atopic Dermatitis: a randomised, double-blind, placebo-controlled, two-centre trial - study protocol

Complementary integrative approach for treating pruritus

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