Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis

Yang, Wenting; Zheng, Xuan-Qi; Chen, Shuang; Shan, Chun-Shuo; Xu, Qingqing; Zhu, Jun; Bao, Xiaoyi; Lin, Yan; Zheng, Guo-Qing; Wang, Yan

doi:10.1016/j.bcp.2017.07.002

Cited by 118 publications

(88 citation statements)

References 56 publications

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“…The results of similar researches also showed that adjuvant herbal therapy may be beneficial in treatment of VaD, AD, and other neurodegenerative diseases by inducing hippocampal neurogenesis. Moreover, it has been reported that although monotherapy of medicinal plants may not be as effective as adjuvant therapy, herbal medicines are well tolerated in patients with AD and can improve cognitive functions in VaD patients (Yang et al, ). The results of studies on therapeutic effects of saffron have also shown that saffron improves cognition in patients with AD (Akhondzadeh et al, ).…”

Section: Discussionmentioning

confidence: 99%

Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review

Ghorani‐Azam

Sepahi

Khodaverdi

et al. 2018

Phytotherapy Research

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Vascular dementia (VaD) generally refers to memory deficits and cognitive abnormalities that are resulted from vascular disease. In this study, we aimed to systematically review the literature wherein therapeutic effects of medicinal plants have been studied on VaD. A systematic literature search was performed in the PubMed, Scopus, Web of Science, Google Scholar, and other databases using VaD, and medicinal plants as key terms. No strict inclusion criteria were defined, and almost all clinical studies were included. A total of 524 articles were found, of which only 28 relevant articles with 3461 studied patients were included to this systematic review. The results showed that medicinal plants, particularly Sancaijiangtang and Ginkgo biloba could improve behavioral and psychological symptoms, working memory, Mini-Mental State Examination, and activities of daily living as well as neuropsychiatric features. It was also shown that the age, average progression of the disease, and the type of folk medicines effective in treating the disease are important factors in the management of VaD. The results of this review indicated that herbal therapy can be a potential candidate in the treatment of VaD; however, further studies are needed to confirm such efficiency.

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Section: Discussionmentioning

confidence: 99%

Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review

Ghorani‐Azam

Sepahi

Khodaverdi

et al. 2018

Phytotherapy Research

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“…The design, implementation, and reporting of outcomes of this study were conducted according to the Preferred Reporting Items for systematic reviews and meta-analyses: The PRISMA Statement (Moher et al, 2009) and our previous articles (Yang et al, 2017). …”

Section: Methodsmentioning

confidence: 99%

Chinese Herbal Medicine for Myasthenia Gravis: A Systematic Review and Meta-Analysis

Chen

Zhou

et al. 2018

Front. Pharmacol.

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Myasthenia gravis (MG) is an acquired autoimmune disease with the disorder of the neuromuscular junction transmission caused by autoantibodies. Currently, various Chinese herbal medicines (CHMs) are widely used for MG. This meta-analysis was conducted to assess the effectiveness and safety of CHMs for MG and its possible mechanisms. Fourteen studies with 1039 individuals were identified by searching seven databases from inception to March 2017. The methodological quality was assessed by using 7-item criteria from the Cochrane’s Collaboration tool, and which assessed ≥4 “yes” in the domains were selected for detailed assessment and meta-analysis. All the data were analyzed using Rev-Man 5.3 software. Meta-analysis showed a significant effect of CHM as adjuvant therapy for improving the effectiveness compared with WCM alone or placebo in treating MG (p < 0.01). Moreover, there were fewer adverse effects and relapse rate in total when compared with the control group. The possible mechanisms of CHM for MG are associated with immunoregulation by reconstituting the functional ability of Tregs. In conclusion, despite the apparent positive results, the present evidence supports, to an extent, that CHM can be used for MG patients because of the methodological flaws and CHM heterogeneity. Further rigorous RCT for MG is needed.

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“…[9][10][11] The anti-AD agents from TCM have been developed for a long time. 12,13 Rhynchophylline (RIN) is a major active tetracyclic oxindole alkaloid stem from traditional Chinese medicine uncaria species. 14 RIN has been used commonly in the treatment of central nervous system diseases including hypertension, convulsions, stroke, as well as AD.…”

Section: Introductionmentioning

confidence: 99%

<p>Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer’s Disease</p>

Xu¹,

Wang²,

Xu³

et al. 2020

IJN

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Purpose: Alzheimer's disease (AD) is a growing concern in the modern society. The current drugs approved by FDA are not very promising. Rhynchophylline (RIN) is a major active tetracyclic oxindole alkaloid stem from traditional Chinese medicine uncaria species, which has potential activities beneficial for the treatment of AD. However, the application of rhynchophylline for AD treatment is restricted by the low water solubility, low concentration in brain tissue and low bioavailability. And there is no study of brain-targeting therapy with RIN. In this work, we prepared rhynchophylline loaded methoxy poly (ethylene glycol)-poly (dl-lactide-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPS-RIN), which coupled with Tween 80 (T80) further for brain targeting delivery (T80-NPS-RIN). Methods: Preparation and characterization of T80-NPS-RIN were followed by the detection of transportation across the blood-brain barrier (BBB) model in vitro, biodistribution and neuroprotective effects of nanoparticles. Results: The results indicated T80-NPS-RIN could usefully assist RIN to pass through the BBB to the brain. T80-NPS-RIN treatment regulated the activity of neurons in vitro. Conclusion: The presented data confirmed that rhynchophylline encapsulated mPEG-PLGA nanoparticles coated with Tween 80 could across through the BBB and exhibited efficient neuroprotective effects. The T80-NPS-RIN nanoparticles have a chance to be an alternative drug to the therapy of AD.

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Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis

Cited by 118 publications

References 56 publications

Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review

Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review

Chinese Herbal Medicine for Myasthenia Gravis: A Systematic Review and Meta-Analysis

<p>Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer’s Disease</p>

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