Chinese Herbal Medicine Decreases Incidence of Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease in Taiwan: A Propensity Score-Matched Cohort Study

Huang, Chia-Yu; Wu, Mei-Yao; Wang, Hsiang-Chi; Liao, Yuan-Ching; Tou, Sio-Ian; Yen, Hung-Rong

doi:10.1089/acm.2020.0494

Cited by 7 publications

(9 citation statements)

References 39 publications

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“…A nationwide, population-based, 1:1 propensity scorematched cohort study by Insurance Database 2000, 21,24,25 which contains all of the original claims data of 1 million beneficiaries randomly sampled from the registry of all beneficiaries in 2000, was our data source. 22 There was no significant difference in our sample and the general population in age, sex, birth year, or average insured payroll-related costs. Diagnosis was coded by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM).…”

Section: Data Sourcesmentioning

confidence: 55%

“…20 Since 1996, traditional Chinese medicine (TCM) services have been reimbursed through the NHI program, which covers more than 99% of the Taiwanese population. 21,22 All of the claims data were deidentified and then stored in the Taiwanese National Health Insurance Research Database (NHIRD) for research purpose. 20 The large-scale real-world data without sampling bias is one of the advantages of this database.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Huang

Sun

et al. 2021

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Background: Major depressive disorder is a significant public health concern, which often leads to loss of productivity, functional decline, and various complications. The aim of this study was to investigate the effectiveness of acupuncture in the risk reduction of coronary heart disease (CHD) in patients with depression. Methods: We enrolled patients diagnosed with depression between January 1, 1997, and December 31, 2010, through the Taiwanese National Health Insurance Research Database (NHIRD). Propensity score was used to match equal numbers (n=14,647) of acupuncture cohort and no-acupuncture cohort based on characteristics including sex, age, baseline comorbidity and medication. Patients were followed up until December 31, 2013, or withdrawn from the NHIRD. The Cox regression model was used to compare the hazard ratios (HRs) of CHD in the two cohorts. Results: The basic characteristics of the two groups were similar. A lower cumulative incidence of CHD was noted in the acupuncture cohort (Log rank test, p < 0.001). Over time, 1626 patients in the acupuncture cohort (21.05 per 1000 person-years) and 2412 patients in the no-acupuncture cohort (39.84 per 1000 person-years) developed CHD (adjusted HR=0.50, 95% CI 0.47-0.53). The decreased CHD incidence was independent of age, sex, comorbidities, and medications used. The cumulative incidence of CHD was significantly lower in the acupuncture cohort than in the no-acupuncture cohort (Log rank test, p<0.001). Conclusion:The results provided a real-world evidence that acupuncture may have beneficial effect on CHD risk reduction in patients with depression.

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Section: Data Sourcesmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Huang

Sun

et al. 2021

NDT

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“…Similarly, ICD-10-CM codes K75.0 (for NAFLD) and K76 (for NASH) were also applied by population-based studies (52,53). Definitions relating to exposure, outcomes and covariates of diseases applied in this study were based on previous population-based observational studies (4,(22)(23)(24)(54)(55)(56). In addition to applying definition utilized by previous studies, to strengthen the validity of the definition, we also excluded people with less than one impatient or two outpatient records in our study.…”

Section: Discussionmentioning

confidence: 99%

“…However, though limited by the available data in current datasets, in the present study, we did try our best to make the definition of NAFLD as convincible as possible. The code ICD-9-CM 571.8 has been utilized as NAFLD definition in previous studies ( 22 , 51 ). Similarly, ICD-10-CM codes K75.0 (for NAFLD) and K76 (for NASH) were also applied by population-based studies ( 52 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with a record of more than two outpatient visits or one inpatient visit for NAFLD were included in the NAFLD cohort. This definition has been applied in previous population-based studies in Taiwan ( 4 , 22 ). Patients below 18 years old at the index date and those who had died or withdrawn from the NHI program before the study endpoint were excluded.…”

Section: Methodsmentioning

confidence: 99%

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Bidirectional Association Between Psoriasis and Nonalcoholic Fatty Liver Disease: Real-World Evidence From Two Longitudinal Cohort Studies

et al. 2022

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BackgroundAssociation between nonalcoholic fatty liver disease (NAFLD) and future psoriasis has not yet been confirmed, although the two diseases partially share a common pathogenesis pathway. Studies have revealed an association between psoriasis and subsequent NAFLD; however, these studies were limited to small sample sizes and a cross-sectional study design. Hence, the main objective of this population-based longitudinal cohort study was to evaluate the bidirectional association between psoriasis and NAFLD.MethodsData were retrieved from Taiwan’s National Health Insurance Research Database. Patients with new-onset NAFLD and psoriasis were respectively enrolled in two cohorts. For each comparison cohort, propensity-score-matched controls with no record of NAFLD or psoriasis were selected. An adjusted hazard ratio (aHR) was applied to evaluate subsequent risks.ResultsThe risk of patients with new-onset NAFLD developing psoriasis was statistically significant, with an HR of 1.07 (95% CI, 1.01–1.14). For younger patients with NAFLD, the risk of developing psoriasis was 1.3-fold higher. The risk of patients with new-onset psoriasis developing NAFLD in the future was 1.28-fold higher than that of patients without psoriasis (95% CI, 1.21–1.35), and patients in younger psoriasis subgroups below the age of 40 years were at a higher risk than those in older subgroups, with an aHR of 1.55 (95% CI, 1.40–1.71).ConclusionEvidence supports a bidirectional association between NAFLD and psoriasis, especially in patients below the age of 40 years. The correlation between the two diseases and the subsequent risk of disease development should be considered when caring for patients.

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Coprescription Trends in Western Medicine, Chinese Herbal Medicine and Dental Medicine among Older Adults in Taiwan from 1997 to 2013

Huang

Chang

et al. 2021

Complementary Therapies in Medicine

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Chinese Herbal Medicine Decreases Incidence of Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease in Taiwan: A Propensity Score-Matched Cohort Study

Cited by 7 publications

References 39 publications

Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study

Bidirectional Association Between Psoriasis and Nonalcoholic Fatty Liver Disease: Real-World Evidence From Two Longitudinal Cohort Studies

Coprescription Trends in Western Medicine, Chinese Herbal Medicine and Dental Medicine among Older Adults in Taiwan from 1997 to 2013

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