Chinese herbal medicine adjunct therapy in patients with acute relapse of multiple sclerosis: A systematic review and meta-analysis

Song, Lina; Zhou, Qihui; Wang, Huilin; Liao, Feng-jiao; Hua, Liang; Zhang, Hongfeng; Huang, Libo; 鄭, 国慶

doi:10.1016/j.ctim.2017.02.004

Cited by 28 publications

(33 citation statements)

References 27 publications

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“…In a systematic review that included studies in the Chinese language, twenty studies on Chinese herbal medicine for Relapsing-Remitting Multiple Sclerosis (RRMS) were evaluated. 90 The top five most used herbs were Angelica sinensis radix (当归 dāng guī ), Glycyrrhizae radix (甘草 gān cǎo ), Paeonia rubra radix (赤芍 chì sháo ), Rehmanniae preparata radix (熟地黃 shú dì huáng ), and Bomby batryticatus (僵蚕 jiāng cán ). This meta-analysis showed a significant effect of the TCM herbs in improving expanded disability status scale (EDSS) (P < 0.01), annual relapse rate (P < 0.01), and total clinical efficacy rate (P < 0.01) of the MS subjects when compared with the western conventional treatments.…”

Section: Discussionmentioning

confidence: 99%

“…This meta-analysis showed a significant effect of the TCM herbs in improving expanded disability status scale (EDSS) (P < 0.01), annual relapse rate (P < 0.01), and total clinical efficacy rate (P < 0.01) of the MS subjects when compared with the western conventional treatments. 90 The other herbs found to be frequently used for MS were Radix astragali seu hedysari (黄芪 huáng qí ), Herba epimedii (淫羊藿 yín yáng huò ), Scorpio (全蝎 quán xiē ), Semen coicis (薏苡仁 yì yǐ rén ), Achyranthis bidentatae radix (牛膝 niú xī ), Poria (茯苓 fú líng ), Pinelliae rhizome (半夏 bàn xià ), Semen Cuscata (菟丝子 tù sī zǐ ), Atractylodes Macrocephalae rhizome (白术 bái zhú ), Ligustici rhizome (川芎 chuān xiōng ), Rehmanniae recens radix (生地黃 shēng dì huáng ), Herba cistanches (肉苁蓉 ròu cōng róng ), Arisaematis cum bile (胆南星 dǎn nán xīng ) , and Lumbicus (地龙 dì lóng ). 90 Four of the herbs in this complete list are included as core herbs of BZYQT and HQRST ( Fig.…”

Section: Discussionmentioning

confidence: 99%

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The “Treatise on the spleen and stomach” (Pí Wèi Lùn) as the first record of multiple sclerosis in the medical literature – A hypothesis based on the analysis of clinical presentation and herbal medicine

Fuzimoto

Brigo

2020

Journal of Traditional and Complementary Medicine

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Background The “Treatise on the spleen and stomach” ( Pí Wèi Lùn ) is the work of the scholar and physician Li Gao ( Jin-Yuan dynasties, 1115–1368 C.E., China). Li Gao described a clinical presentation that today would fall under the diagnosis of Multiple Sclerosis (MS) and proposed the treatment with herbal medicine and nutritional guidelines. The PWL is well known for its application in the treatment of MS and autoimmune conditions. However, this theoretical “MS” has not yet been analyzed through a scientific investigation, and research on its herbal formulations for MS is scant. Methods We analyzed the PWL “MS” clinical presentation considering biomedical diagnostic criteria and neurological correlates. To support our review, we searched Pubmed for studies on the PWL main herbal formulas and their herbs/isolates used for the believed “MS” which treated experimental autoimmune encephalomyelitis (EAE)/MS. Results We found a very close correlation between the PWL “MS” and the current MS diagnosis. Twenty four studies on the herbs-isolates showed significant amelioration of EAE, neuronal damage, and demyelination. Discussion Collectively, Astragali radix , Ginseng radix , Glycyrrhizae radix , and berberine containing Phellodendri cortex reduced the severity of EAE through different signaling pathways and mechanisms of action. These herbs provided a wide range of properties such as anti-inflammatory, anti-oxidant, anti-microglial activation, anti-infiltration of leukocytes, apoptotic/anti-apoptotic balance, and neuronal protection. Conclusion Our review proposes that the PWL is the first record of MS in the medical literature. Its formulas and herbs-isolates offer a fertile area for MS research and an invaluable potential for its treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The “Treatise on the spleen and stomach” (Pí Wèi Lùn) as the first record of multiple sclerosis in the medical literature – A hypothesis based on the analysis of clinical presentation and herbal medicine

Fuzimoto

Brigo

2020

Journal of Traditional and Complementary Medicine

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“…[105][106][107] RG has a wide range of clinical applications. It is currently reported that RG can be used to treat attention deficit hyperactivity disorder, 108 PD 109 , multiple sclerosis, 110 anxiety, 111 and memory disorders, 112 and it inhibits inflammatory responses 113,114 and has anti-fatigue activity. 115 In the theory of TCM, liver depression and blood deficiency are manifested as depression, anxiety, insomnia, palpitations, inattention, and other depressive symptoms.…”

Section: Rehmannia Glutinosa (Gaertn) DCmentioning

confidence: 99%

<p>Traditional Chinese Medicine Jiuwei Zhenxin Granules in Treating Depression: An Overview</p>

Wang

2020

NDT

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Depression is known as "Yu Zheng" in traditional Chinese medicine (TCM). Jiuwei Zhenxin granules (JZG) is a type of TCM. According to TCM theory, it nourishes the heart and spleen, tonifies Qi, and tranquilizes the spirit, and may also has effects in the treatment of depression. Here, we systematically reviewed recent basic and clinical experimental studies of JZG and depression, including studies of the pharmacological mechanisms, active ingredients, and clinical applications of JZG in depression treatment. This review will deepen our understanding of the pharmacological mechanisms, drug interactions, and clinical applications of TCM prescriptions and provide a basis for the development of new drugs in the treatment of depression.

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“…Traditional Chinese medicine (TCM) has been used for neurodegenerative diseases including MS (Liu et al, 2012 ). Radix Rehmanniae (RR), is one of the most frequent used herbal items in TCM formulas for MS patients (Song et al, 2017 ). RR exerts various bioactivities such as anti-osteoporotic (Oh et al, 2003 ), anti-inflammatory (Kim et al, 1999 ; Lau et al, 2009 ), immunomodulatory (Kim et al, 1998 ; Sung et al, 2011 ) and neuroprotective effects (Yu et al, 2006 ; Lee et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-Derived Nitrative Damage

Gao

et al. 2018

Front. Physiol.

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Multiple sclerosis (MS) is a neuroinflammatory disease in central nervous system (CNS) without effective treatment or medication yet. With high prevalence of MS patients worldwide and poor therapeutic outcome, seeking novel therapeutic strategy for MS is timely important. Radix Rehmanniae (RR), a typical Chinese Medicinal herb, has been used for neuroinflammatory diseases in Traditional Chinese Medicine for centuries. However, scientific evidence and underlying mechanisms of RR for MS are unclear. In this study, we tested the hypothesis that RR could attenuate the progress and severity of MS via suppressing macrophage-derived nitrative damage and inflammation by using experimental autoimmune encephalomyelitis (EAE) model for mimicking MS pathology. The results showed the RR treatment effectively ameliorated clinical disease severity, inhibited inflammation/demyelination in spinal cord, and alleviated CNS infiltration of encephalitogenic T cells and activated macrophages. Meanwhile, RR possessed bioactivities of scavenging ONOO− and reducing the expression of iNOS and NADPH oxidases in the spinal cords of the EAE mice. Furthermore, RR treatment suppressed nuclear factor-κB (NF-κB) signaling pathway in the splenocytes of EAE mice. The in vitro experiments on macrophages and neuronal cells exerted consistent results with the in vivo animal experiments. Taken together, we conclude that Radix Rehmanniae extract has therapeutic values for ameliorating EAE/MS pathological process and disease severity and its underlying mechanisms are associated with anti-inflammation and inhibiting macrophage-derived nitrative damages. Further study could yield novel promising therapeutic agent for multiple sclerosis.

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Chinese herbal medicine adjunct therapy in patients with acute relapse of multiple sclerosis: A systematic review and meta-analysis

Cited by 28 publications

References 27 publications

The “Treatise on the spleen and stomach” (Pí Wèi Lùn) as the first record of multiple sclerosis in the medical literature – A hypothesis based on the analysis of clinical presentation and herbal medicine

The “Treatise on the spleen and stomach” (Pí Wèi Lùn) as the first record of multiple sclerosis in the medical literature – A hypothesis based on the analysis of clinical presentation and herbal medicine

<p>Traditional Chinese Medicine Jiuwei Zhenxin Granules in Treating Depression: An Overview</p>

Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-Derived Nitrative Damage

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