China rheumatoid arthritis registry of patients with Chinese medicine (CERTAIN): Rationale, design, and baseline characteristics of the first 11,764 enrollees

Gong, Xun; Liu, Wei-xiang; Li, Da; Peng, Qiuwei; Xia, Cong-min; Tian, Chao; Guan, Jin-zhi; Song, Meng-ge; Zhang, Fu-yuan; Tang, Xiaopo; Liu, Ying; Liu, Jian; Peng, Jiang-yun; He, Dongyi; Huang, Qingchun; Gao, Ming-Li; Yu, Jie; Liu, Wei; Zhang, Jianyong; Zhu, Yue-lan; Hou, Xiaofeng; Wang, Haidong; Fang, Yongfei; Wang, Yue; Su, Yin; Tian, Xin; Su, Xiao; Meng, Qingliang; Wen, Shu-yun; Wang, Bei; Li, Zeguang; Liu, Ju; Jiang, Hong; Hu, Yan; Li, Huiling; Wei, Shufeng; Zhu, Wanhua; Lu, Aiping; Zhang, Chi; Jiang, Quan

doi:10.1016/j.phymed.2022.154236

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…In addition, the enforcement of regulations poses a significant challenge in the expansive TCM market, raising concerns about the potential sale of non-compliant TCMs and endangering patients' well-being [ 77 , [85] , [86] , [87] ]. We suggest the implementation of a feasible drug surveillance system and the establishment of a risk-benefit analysis framework to regulate TCM in a scientifically sound manner.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy evaluation of Simo decoction and Arecae semen in herbal medicine practice

Huang,

Wen,

Yang

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy evaluation of Simo decoction and Arecae semen in herbal medicine practice

Huang,

Wen,

Yang

et al. 2024

Heliyon

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“…Based on the previous investigation on the current status of traditional Chinese medicine in the treatment of RA in the country, it was found that ORHXD was the most frequently used Chinese medicine prescription. [31] From a cohort study of 11,764 patients enrolled through November 2021, we identi ed 1,347 patients who received QRXD for more than 3 months after entering CERTAIN. Of these, 528 (39.2%) patients had DAS28-CRP < 2.6 [31].…”

Section: Discussionmentioning

confidence: 99%

“…[31] From a cohort study of 11,764 patients enrolled through November 2021, we identi ed 1,347 patients who received QRXD for more than 3 months after entering CERTAIN. Of these, 528 (39.2%) patients had DAS28-CRP < 2.6 [31]. Based on this theory, we formulate the treatment plan of QRHXD.…”

Section: Discussionmentioning

confidence: 99%

Observation of the bone destruction of Qingre Huoxue Decoction in the treatment of active rheumatoid arthritis based on MRI evaluation: study protocol for a multicenter, randomized, double-blinded, controlled clinical trial

Liu

李

Tang

et al. 2022

Preprint

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Background: Bone destruction is the key and difficult point in the treatment of RA. Studies have found that the use of traditional Chinese medicine Qingre Huoxue Decoction (QRHXD) can effectively reduce disease activity and delay bone destruction. Magnetic resonance imaging (MRI) is one of the effective ways to evaluate bone destruction in RA in real time, which is helpful to the early evaluation and discovery of synovitis and bone destruction. Therefore, we designed a multicenter, randomized, double-blinded, controlled clinical trial to assess the improvement of the bone destruction of QRHXD in treating RA using MRI. Methods: This study aimed to assess the definitive evidence that the traditional Chinese medicine QRHXD slows bone destruction in RA using MRI. A total of 204 adult participants with RA will be enrolled, with balanced treatment allocation (1:1). The experimental intervention will be QRHXD plus MTX and the control intervention will be QRHXD placebo plus MTX for 24 weeks. The primary outcome measure will be RA MRI score at screening period and 24 weeks. Secondary outcome measures will include the ACR20, ACR50 and ACR70, DAS28, patient report outcome(PRO), health assessment questionnaire(HAQ) and X-ray sharp score of both hands. In addition, the vital signs and adverse reactions of the subjects will be recorded. Discussion: The purpose of this study is to use MRI to confirm that QRHXD can effectively slow the imaging progress of active RA. To provide evidence for the efficacy of Chinese medicine in delaying bone destruction in RA, and help to carry out more clinical research on Chinese medicine prescriptions. Trial registration number Clinical Trials.gov ID: NCT04170504.

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“…However, influencing factors associated with the choice of using CHM of the patients have not been sufficiently researched. Given the contemporary popularity and significance of CHM use in China and women are more susceptible to arthritis 18 , 19 , it is vital to identify factors associated with CHM use amongst Chinese women with arthritis to help inform safe, effective and coordinated care. Therefore, in response to this research gap, the aim of this study is to examine the prevalence of CHM usage amongst women with arthritis and the factors associated with the choice of using CHM treatment among those women with arthritis.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with Chinese herbal medicine use among middle-aged and older women with arthritis: evidence from China

Yang

Sibbritt

2022

Sci Rep

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Chinese herbal medicine (CHM) has been used for arthritis in China and elsewhere across the world. However, knowledge about the prevalence and profile of middle-aged and older women who used CHM for arthritis in China is limited. This study aims to identify potentially important insights into the factors associated with CHM use amongst middle-aged and older women with arthritis in China. Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS), a population-based survey of Chinese adults aged 45 years or older, comprising 10,833 Chinese women who completed a questionnaire in 2015. Stepwise multiple logistic regression modeling was conducted to determine the key factors (demographic, health condition, and health services use) predicting the use of CHM for the treatment of arthritis. Results revealed that 17.2% of women with arthritis were taking CHM for their arthritic symptoms. Women with arthritis who used CHM were more likely to experience finger pain (OR = 1.70), had difficulty in stooping, kneeling, crouching (OR = 1.40), visited a Traditional Chinese hospital (OR = 2.22), consulted massage therapists (OR = 2.06) and/or had experienced a fall (OR = 1.41). The prevalence of CHM use is high amongst middle-aged and older Chinese women with arthritis. Given the high risk of functional disability and impaired mental health, further research is needed to explore the potential health benefits of CHM for women with arthritis in order to help facilitate the efficacious and safe use of CHM alongside conventional medical care.

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China rheumatoid arthritis registry of patients with Chinese medicine (CERTAIN): Rationale, design, and baseline characteristics of the first 11,764 enrollees

Cited by 3 publications

References 22 publications

Safety and efficacy evaluation of Simo decoction and Arecae semen in herbal medicine practice

Safety and efficacy evaluation of Simo decoction and Arecae semen in herbal medicine practice

Observation of the bone destruction of Qingre Huoxue Decoction in the treatment of active rheumatoid arthritis based on MRI evaluation: study protocol for a multicenter, randomized, double-blinded, controlled clinical trial

Factors associated with Chinese herbal medicine use among middle-aged and older women with arthritis: evidence from China

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