China faces the challenge of influenza A virus, including H3N8, in the post-COVID-19 era

Cai, Juncheng; Ruan, Jiayu; Lin, Qiuyan; Ren, Tao; Chen, Libin

doi:10.1016/j.jinf.2023.06.004

Cited by 2 publications

(1 citation statement)

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“…Common respiratory diseases, such as flu, cold, and even pneumonia, rebound with similar patterns worldwide after lifting the COVID-19 restrictions. − Pandemic measures have reduced population exposure to such bacteria or viruses, and people are less likely to build up immunity against these pathogens. − In the post-COVID-19 era, flu still poses a challenge to most countries. − In addition to annual vaccination, antiviral drugs also serve as an important defense against flu for their effectiveness in symptom alleviation, wide availability, and good patient compliance …”

Section: Introductionmentioning

confidence: 99%

Identification, Synthesis, Characterization, and Control Strategy Establishment for Process Impurities of Baloxavir Marboxil

Lu,

Xu,

Kou

et al. 2024

Org. Process Res. Dev.

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This manuscript provides a comprehensive summary of 12 process impurities in baloxavir marboxil, including four previously unreported impurities. Through identification, synthesis, and characterization using MS and NMR techniques, the formation pathways of each impurity were proposed to enhance the understanding of the process. Corresponding control strategies were established. Three batches of kilogram-scale demonstrations were conducted, resulting in baloxavir marboxil with a yield of 51%, purity exceeding 99.8%, and a single impurity detected at <0.10%, all achieved from chiral starting material A-1. Notably, the two genotoxic impurities were effectively purged to levels below detection limits, meeting the criteria specified by the Threshold of Toxicological Concern (TTC).

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