Chimerism of the Transplanted Heart

Quaini, Federico; Urbanek, Konrad; Beltrami, Antonio Paolo; Finato, Nicoletta; Beltrami, Carlo Alberto; Nadal‐Ginard, Bernardo; Kajstura, Jan; Leri, Annarosa; Anversa, Piero

doi:10.1056/nejmoa012081

Cited by 1,149 publications

(707 citation statements)

References 37 publications

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“…6 These small interstitial cells could be found expressing c-Kit, MDR-1, or Sca-1 and contained a subset that coexpressed markers of cardiac-specific differentiation (GATA4 or α-sarcomeric actin). These cell populations were markedly increased in transplanted human hearts, and only 12% to 16% could be identified as recipient derived (e.g., blood-or bone marrow-derived cells) by expression of the Y chromosome in males transplanted with female donor hearts.…”

Section: C-kit + Cardiac Stem Cellsmentioning

confidence: 97%

Stem cells in the heart: What's the buzz all about?—Part 1: Preclinical considerations

et al. 2008

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New approaches for cardiac repair have been enabled by the discovery that the heart contains its own reservoir of stem cells. These cells are positive for various stem/progenitor cell markers, are selfrenewing, and exhibit multilineage differentiation potential. Recently we developed a method for ex vivo expansion of cardiac-derived stem cells from human myocardial biopsies with a view to subsequent autologous transplantation for myocardial regeneration. Here we review the state of the cardiac stem cell field and our own work on cardiosphere-derived stem cells from human hearts. The first of this two-part review outlines emerging preclinical data on the application of cardiac stem cells. Part 2 continues with a discussion of other stem cell sources with clinical potential, a summary of the critical issues surrounding stem cell therapy (with an emphasis on the crucial issue of how cell transplantation may influence arrhythmias), our perception of clinical stem cell trials to date, and the issues facing the clinical application of cardiac stem cells.

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Section: C-kit + Cardiac Stem Cellsmentioning

confidence: 97%

Stem cells in the heart: What's the buzz all about?—Part 1: Preclinical considerations

et al. 2008

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“…Recent studies indicate a significant contribution of stem cells, likely of bone marrow origin, to the homeostasis and/or repair of the adult heart (Jackson et al, 2001;Orlic et al, 2001;Hughes, 2002;Laflamme et al, 2002;Quaini et al, 2002). In addition, the existence of a socalled myocardial stem cell population has been suggested (Hierlihy et al, 2002), but it is not clear how this population contributes to the respective established cardiac cell types in the heart, nor has the origin/phenotype of these cells been properly described.…”

Section: Contributions Of Stem Cells To the Adult Heartmentioning

confidence: 99%

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

2003

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After its initial formation the epicardium forms the outermost cell layer of the heart. As a result of an epithelial-to-mesenchymal transformation (EMT) individual cells delaminate from this primitive epicardial epithelium and migrate into the subepicardial space (Pérez-Pomares et al., Dev Dyn 1997; 210: 96 -105; Histochem J 1998a;30:627-634 Dev. Biol. 2002b;247:307-326). A subset of EPDCs continue to differentiate in a variety of different cell types (including coronary endothelium, coronary smooth muscle cells (CoSMCs), interstitial fibroblasts, and atrioventricular cushion mesenchymal cells), whereas other EPDCs remain in a more or less undifferentiated state. Based on its specific characteristics, we consider the EPDC as the ultimate 'cardiac stem cell'. In this review we briefly summarize what is known about events that relate to EPDC development and differentiation while at the same time identifying some of the directions where EPDCrelated research might lead us in the near future. Anat Rec Part A 276A: 43-57, 2004.

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“…Until recently, it was thought that the adult myocardium is a postmitotic tissue. It is now known that cardiac myocytes are regenerated in the adult heart (Beltrami et al, 2001;Quaini et al, 2002). Yet the myocardium is still unable to restore itself in response to severe injury.…”

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confidence: 99%

Stem cells and the formation of the myocardium in the vertebrate embryo

2003

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A major goal in cardiovascular biology is to repair diseased or damaged hearts with newly generated myocardial tissue. Stem cells offer a potential source of replacement myocytes for restoring cardiac function. Yet little is known about the nature of the cells that are able to generate myocardium and the conditions they require to form heart tissue. A source of information that may be pertinent to addressing these issues is the study of how the myocardium arises from progenitor cells in the early vertebrate embryo. Accordingly, this review will examine the initial events of cardiac developmental biology for insights into the identity and characteristics of the stem cells that can be used to generate myocardial tissue for therapeutic purposes. Anat Rec Part A 276A:2-12, 2004.

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Chimerism of the Transplanted Heart

Abstract: Our results show a high level of cardiac chimerism caused by the migration of primitive cells from the recipient to the grafted heart. Putative stem cells and progenitor cells were identified in control myocardium and in increased numbers in transplanted hearts.

Cited by 1,149 publications

References 37 publications

Stem cells in the heart: What's the buzz all about?—Part 1: Preclinical considerations

Stem cells in the heart: What's the buzz all about?—Part 1: Preclinical considerations

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

Stem cells and the formation of the myocardium in the vertebrate embryo

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