Chimerism analyses by sex-chromosome analysis confused relapse with donor cell leukemia after sex-mismatched allo-SCT

Donor Cell Myeloid Sarcoma

“…Any population of cells less than 1% of the total population would be missed. Limitations for XY-FISH may occur with gains and loss of sex chromosomes that can be seen in patients with leukemia [11]. In light of such reports, our patient could have lost his Y chromosome and had a gain of X chromosome in his myeloid sarcoma.…”