Chimeric Viruses Enable Study of Antibody Responses to Human Rotaviruses in Mice
Sarah Woodyear,
Tawny L Chandler,
Takahiro Kawagishi
et al.
Abstract:The leading cause of gastroenteritis in children under the age of five is rotavirus infection, accounting for 37% of diarrhoeal deaths in infants and young children globally. Oral rotavirus vaccines have been widely incorporated into national immunisation programs, but whilst these vaccines have excellent efficacy in high-income countries, they protect less than 50% of vaccinated individuals in low- and middle-income countries. In order to facilitate the development of improved vaccine strategies, a greater un… Show more
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