Chimeric Peptides/Proteins Encoded by circRNA: An Update on Mechanisms and Functions in Human Cancers

Khan, Faiz Ali; Nsengimana, Bernard; Khan, Nazeer Hussain; Song, Zhenhua; Ngowi, Ebenezeri Erasto; Wang, Yunyun; Zhang, Weijuan; Ji, Shaoping

doi:10.3389/fonc.2022.781270

Cited by 17 publications

(8 citation statements)

References 145 publications

(177 reference statements)

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“…It is worth mentioning although, circRNAs were initially thought to function as non-coding RNAs, recent evidence has shown that some circRNAs can encode proteins ( 135 , 136 ) These proteins are synthesized through different mechanism and are typically smaller than canonical proteins ( 130 ). The mechanism of protein coding by circRNAs is still an area of active research and is not completely understood.…”

Section: Noncoding Rnasmentioning

confidence: 99%

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The role of non-protein-coding RNAs in ischemic acute kidney injury

Sabet Sarvestani,

Afshari,

Azarpira

2024

Front. Immunol.

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Acute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in microcirculation. Ischemia-reperfusion injury (IRI) is recognized as a major cause of AKI; however, the precise mechanisms behind this process are not yet fully understood and effective treatments are still needed. To enhance the accuracy of diagnosing AKI during its early stages, the utilization of innovative markers is crucial. Numerous studies suggest that certain noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), play a central role in regulating gene expression and protein synthesis. These ncRNAs are closely associated with the development and recovery of AKI and have been detected in both kidney tissue and bodily fluids. Furthermore, specific ncRNAs may serve as diagnostic markers and potential targets for therapeutic interventions in AKI. This review aims to summarize the functional roles and changes observed in noncoding RNAs during ischemic AKI, as well as explore their therapeutic potential.

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Section: Noncoding Rnasmentioning

confidence: 99%

“…Cap-independent translation Initiation: this method allows them to bypass the traditional mechanism of translation initiation that requires a 5’ cap structure ( 135 ) and can occur through various mechanisms, such as internal ribosome entry sites (IRES) or N6-methyladenosine (m6A) modifications ( 136 ).…”

Section: Noncoding Rnasmentioning

confidence: 99%

The role of non-protein-coding RNAs in ischemic acute kidney injury

Sabet Sarvestani,

Afshari,

Azarpira

2024

Front. Immunol.

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“…[26][27][28][29] CircRNAs are essential in the occurrence and progression of malignant tumors. [30][31][32] For example, circSATB2 was highly expressed in the serum secretions of lung cancer patients, with high sensitivity and specificity for clinical detection. It was also associated with the proliferation, migration, and invasion of lung cancer cells, [33] indicating that circSATB2 might be a promising biomarker for diagnosing lung cancer.…”

Section: Silencing Hsa_circ_0015326 Promotes Apoptosis Of Ovarian Can...mentioning

confidence: 99%

Effects of silencing hsa_circ_0015326 on proliferation, migration, invasion, and apoptosis of epithelial ovarian cancer cells

Zhang,

Liu,

Wang

et al. 2024

J Biochem & Molecular Tox

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Although the treatment of ovarian cancer has made great progress, there are still many patients who are not timely detected and given targeted therapy due to unknown pathogenesis. Recent studies have found that hsa_circ_0015326 is upregulated in ovarian cancer and is involved in the proliferation, invasion, and migration of ovarian cancer cells. However, whether hsa_circ_0015326 can be used as a new target of ovarian cancer needs further investigation. Therefore, the effect of hsa_circ_0015326 on epithelial ovarian cancer was investigated in this study. At first, si‐hsa_circ_0015326 lentivirus was transfected into epithelial ovarian cancer cells. Then real‐time fluorescence quantitative PCR (qRT‐PCR) was used to detect hsa_circ_0015326 level. The proliferation of ovarian cancer cells was detected by CCK‐8 assay. The horizontal and vertical migration abilities of the cells were detected by wound‐healing assay and Transwell assay, respectively. Transwell assay was also used to determine the invasion rate. As for the apoptosis rate, it was assessed by flow cytometry. As a result, the expression level of hsa_circ_0015326 in A2780 and SKOV3 was found to be higher than that in IOSE‐80. However, after transfecting si‐hsa_circ_0015326 and si‐NC into the cells, the proliferation, migration, and invasion abilities of A2780 and SKOV3 cells in the si‐hsa_circ_0015326 group were significantly reduced in comparison to those in the si‐NC and mock groups, while their apoptosis rates were elevated. Collectively, silencing hsa_circ_0015326 bears the capability of inhibiting the proliferation, migration, and invasion of ovarian cancer cells while increasing apoptosis rate. It can be concluded that hsa_circ_0015326 promotes the malignant biological activities of epithelial ovarian cancer cells.

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“…In addition, circular RNAs (circRNAs), a class of highly abundant and evolutionary conserved ncRNAs, are covalently closed RNA molecules that lacks free 3′ and 5′ ends and have recently been identified as functional RNA molecules [ 8 , 9 ]. In addition to their regulatory roles as noncoding transcripts, evidence has recognized that a small portion of lncRNAs and circRNAs contain short open reading frames (sORFs) that can be translated into functional small peptides [ 10 ].…”

Section: The Noncoding Rna Transcriptome In Pulmonary Hypertensionmentioning

confidence: 99%

The Landscape of Noncoding RNA in Pulmonary Hypertension

et al. 2022

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The transcriptome of pulmonary hypertension (PH) is complex and highly genetically heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs in the noncoding transcriptome are long noncoding RNAs (lncRNAs) with less circular RNAs (circRNAs), which are two characteristics gaining increasing attention in the forefront of RNA research field. These noncoding transcripts (especially lncRNAs and circRNAs) exert important regulatory functions in PH and emerge as potential disease biomarkers and therapeutic targets. Recent technological advancements have established great momentum for discovery and functional characterization of ncRNAs, which include broad transcriptome sequencing such as bulk RNA-sequence, single-cell and spatial transcriptomics, and RNA-protein/RNA interactions. In this review, we summarize the current research on the classification, biogenesis, and the biological functions and molecular mechanisms of these noncoding RNAs (ncRNAs) involved in the pulmonary vascular remodeling in PH. Furthermore, we highlight the utility and challenges of using these ncRNAs as biomarkers and therapeutics in PH.

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Chimeric Peptides/Proteins Encoded by circRNA: An Update on Mechanisms and Functions in Human Cancers

Cited by 17 publications

References 145 publications

The role of non-protein-coding RNAs in ischemic acute kidney injury

The role of non-protein-coding RNAs in ischemic acute kidney injury

Effects of silencing hsa_circ_0015326 on proliferation, migration, invasion, and apoptosis of epithelial ovarian cancer cells

The Landscape of Noncoding RNA in Pulmonary Hypertension

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