Chimeric Antisense RNAs

Izant, Jonathan G.; Hoff, A.M.; Sardelli, Alessandra D.; Ford, M. J.

doi:10.1089/ard.1991.1.371

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1996

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“…Chimeric antisense RNAs using tRNAs or small nuclear RNAs as vehicles for antisense RNAs have been successful in reducing target gene expression or viral replication to varying degrees (33,34). However, these systems have failed to take full advantage of the properties of the host molecules, because they have been rendered nonfunctional by the insertion of the antisense RNAs.…”

Section: Discussionmentioning

confidence: 99%

Antisense ribosomes: rRNA as a vehicle for antisense RNAs.

Sweeney

Fan

Yao

1996

Proc. Natl. Acad. Sci. U.S.A.

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Although rRNA has a conserved core structure, its size varies by more than 2000 bases between eubacteria and vertebrates, mostly due to the size variation of discrete variable regions. Previous studies have shown that insertion of foreign sequences into some of these variable regions has little effect on rRNA function. These properties make rRNA a potentially very advantageous vehicle to carry other RNA moieties with biological activity, such as "antisense RNAs." We have explored this possibility by inserting anti-

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Section: Discussionmentioning

confidence: 99%