Chimaphila umbellata extract exerts anti-proliferative effect on human breast cancer cells via RIP1K/RIP3K-mediated necroptosis

Traditional and contemporary herbal medicines in management of cancer: A scoping review

“…Carica papaya, Chelone glabra, Corallium rubrum, Daucus carota, Epifagus virginiana, Lamiastrum galeobolon, Mangifera indica, Nicotiana tabacum and Rumex acetosella (traditional texts) , Cannabis sativa (contemporary) and Antrodia cinnamomea and compound prescriptions of Chinese herbal medicines (case studies) were all identified to be administered specifically to retard cancer growth. While anti-carcinogenic activity of some of these listed herbs has been supported by pre-clinical studies with use of immortalized cancer cell lines [ [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] ], it is important to note that traditional and contemporary clinical use may not be aligned due to incorrect botanical identification or discovery of the herbs' toxicity, thereby altering the preparation and dosage of these herbal extracts over time. For example, traditional evidence shows that Conium maculatum (poison hemlock) ‘retards distress in glandular enlargements in scrofulous or cancerous cachexia’ [ 19 ] in doses of two to six minims of its fluid extract, but it is a well-known as a highly poisonous and deadly herb when ingested due to its toxic alkaloids affecting nerve impulse transmission to muscles causing respiratory failure [ 45 ].…”

Chimaphila umbellata; a biotechnological perspective on the coming-of-age prince’s pine

“…It belongs to the Ericaceae family and is commonly known as Pipsissewa, prince’s pine, or umbellate wintergreen. It is a shrub and grows up to 35 cm with whorled or opposite leaves (Das et al 2022 ). It is an evergreen plant with an umbel or spring of flowers in the latter parts of summer and fall.…”

“…The therapeutic potential of C. umbellata is due to its wide array of phytochemical production including arbutin, sitosterol, ursolic acid, glycoside, hydroquinone, and essential oil (Plants for a future 2022 ). Recent studies have focused on this potential and have examined boils of C. umbellata against tuberculosis (Pathak et al 2021 ), the plant’s antiproliferative effect against MCF-7 cancer cells (Das et al 2022 ), and its activity against cardiovascular diseases.…”