Chilean Strawberry Consumption Protects against LPS-Induced Liver Injury by Anti-Inflammatory and Antioxidant Capability in Sprague-Dawley Rats

Abstract

The Chilean strawberry fruit has high content of antioxidants and polyphenols. Previous studies evidenced antioxidant properties by in vitro methods. However, the antioxidant effect and its impact as functional food on animal health have not been evaluated. In this study, rats were fed with a Chilean strawberry aqueous extract (4 g/kg of animal per day) and then subjected to LPS-induced liver injury (5 mg/kg). Transaminases and histological studies revealed a reduction in liver injury in rats fed with strawberry aqueous extract compared with the control group. Additionally, white strawberry supplementation significantly reduced the serum levels and gene expression of TNF-α, IL-6, and IL-1β cytokines compared with nonsupplemented rats. The level of F2-isoprostanes and GSH/GSSG indicated a reduction in liver oxidative stress by the consumption of strawberry aqueous extract. Altogether, the evidence suggests that dietary supplementation of rats with a Chilean white strawberry aqueous extract favours the normalization of oxidative and inflammatory responses after a liver injury induced by LPS.

Fragaria Genus: Chemical Composition and Biological Activities

“…Thus, the higher levels of bioactive molecules in the Fragaria x ananassa fruits (compared with the F. vesca leaves, as previously presented) can explain the differences observed by the authors in terms of anti-inflammatory action. Similar observations were made by Molinett et al [82] who proved the anti-inflammatory and hepatoprotective effect of aqueous F. chiloensis fruits extracts on LPS-inducted liver injury on rats. The anti-inflammatory effect of the Fragaria x ananassa var.…”

Emodin Attenuates Lipopolysaccharide-Induced Acute Liver Injury via Inhibiting the TLR4 Signaling Pathway in vitro and in vivo

“…LPS, a large molecule consisting of a polysaccharide and a lipid, is the main constituent of the outer membrane of intracellular Gram-negative bacteria and can activate liver macrophages, which advances the secretion of inflammatory cytokines. LPS damages the liver by serving as a hepatotoxin ( Gao et al, 2015 ; Molinett et al, 2015 ; Tang et al, 2016 ; Singh et al, 2017 ). No specific treatment interventions are currently available for LPS-induced acute liver injury (ALI).…”

Southern Species From the Biodiversity Hotspot of Central Chile: A Source of Color, Aroma, and Metabolites for Global Agriculture and Food Industry in a Scenario of Climate Change

“…Chilean white fruit aqueous extracts have a protective effect on platelet aggregation (Parra-Palma et al, 2018) and can exert protection on human epithelial gastric cells against free radical-induced damage (Avila et al, 2017). On the other hand, dietary supplementation of rats with white Chilean strawberry juice favors the normalization of oxidative and inflammatory effects in response to a liver injury induced by lipopolysaccharides (Molinett et al, 2015). These results support the idea to considerate the Chilean strawberry fruit as a functional food.…”