Children with lymphadenitis associated with Bacillus Calmette-Guérin (BCG) vaccination do not experience more infections when compared with BCG-vaccinated children without lymphadenitis: a three years paired-cohort in Mexico

Chacón-Cruz, Enrique; Arellano-Estrada, Jorge Luis; Lopatynsky-Reyes, Erika Zoe; Alvelais-Palacios, Jorge Arturo; Becka, Chandra

doi:10.1177/2051013617741585

Cited by 3 publications

(3 citation statements)

References 14 publications

(26 reference statements)

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“…However, outcomes vary with the pulmonary form of the disease, with some showing a null effect and others close to 80%. In the study conducted at the Bahawal Victoria Hospital Pediatric Unit II in Bahawalpur, 76 of the 100 tuberculosis patients admitted during this period were vaccinated and 24 were unvaccinated 21 [22][23] . International data showing that BCG has a greater preventive effect in meningeal tuberculosis and less in pulmonary tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Several Forms of Tuberculosis (TB) and Their Bacillus Calamette Guerin (BCG) Vaccination Status among Children

Mazhar¹,

Khan²,

Qaisar³

et al. 2022

PJMHS

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Aim: The purpose of the study was to govern the incidence of various forms of tuberculosis and the status of BCG vaccination in children. Study design: A Cross-sectional study. Place and Duration of the Study: In the Pediatrics department of Jinnah hospital, Lahore for one-year duration from January 2021 to December 2021. Methods: A total of 200 patients with various forms of tuberculosis were recruited who met the inclusion and exclusion criteria. A demographic profile including age, gender and hospital registration numbers is recorded. Informed oral consent was obtained from the parents of each child. BCG scar present or absent. Form of tuberculosis, pulmonary tuberculosis (fever> 14 days, ESR> 50, sputum positive for AFB, x-ray results), tuberculous meningitis (fever with focal neurological symptoms lasting longer than 14 days, CT results according to inclusion criteria, CSF pleocytosis), tuberculous lymphadenitis (detection of tuberculosis by histopathology on excisional lymph node biopsy), abdominal tuberculosis (fever longer than 14 days, previous weight loss and anorexia, mesenteric lymphadenitis, biopsy of the lesion suggestive of tuberculosis), description and labelling of the vaccinated and unvaccinated patient with the presence or absence of BCG scar. Results: During this period, 200 patients who met the exclusion and inclusion criteria were selected in the study. Of the 200 patients included, 110 (55%) were males and 90 (45%) were females (Table 1), their age varies from 1 to 14 years, with 7.22 ± 3.78 years of an average age. Out of 200 enrolled patients, the four most common types of tuberculosis were examined. Out of 200 cases, 95 (47.5%) were pulmonary tuberculosis, 50 (25%) tuberculous meningitis, 35 (17.5%) tuberculous lymphadenitis, and 25 (12.5%) abdominal tuberculosis. Of the 200 patients enrolled, 85 (42.5%) were vaccinated (with BCG scarring) and 115 (57.5%) were unvaccinated. Keywords: Tuberculosis, BCG, Pulmonary tuberculosis

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Section: Discussionmentioning

confidence: 99%

Incidence of Several Forms of Tuberculosis (TB) and Their Bacillus Calamette Guerin (BCG) Vaccination Status among Children

Mazhar¹,

Khan²,

Qaisar³

et al. 2022

PJMHS

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“…BCG vaccine is usually a safe vaccine, a number of complications can occur, such as adverse local reactions, regional lymphadenitis, osteomyelitis and disseminated infection in immunocompromised children with (4) lymphadenitis being the most common. The presentation rate of BCG (5) lymphadenitis is <1 per 1000 vaccinated children. Its incidence differs depending on the particular vaccine, the age of the child at the (6) time of vaccination and probably some other factors.…”

Section: Introductionmentioning

confidence: 95%

Fnac as a Tool in the Diagnosis of BCG Induced Lymphadenitis-an Institutional Experience.

Sravani¹,

Bhavani

Naik

et al. 2020

ijsr

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Background: Tuberculosis is a major cause of mobility and mortality in developing countries including India.BCG vaccine has been in use since 1921 and is considered to be one of the safest vaccines with self limited regional Lymphadenopathy being the most common complication. Objectives: The present study aims toevaluate the efficacy and cytomorphological patterns of BCG lymphadenitis. Materials & methods: This cross-sectional study was conducted in the Department of Pathology of Government Medical College / Government General Hospital, Anantapuramu, during the period January 2017 to December 2019. Patients with suspected ipsilaterallymphnodal enlargement after BCG vaccination and age ranging from two months to two years , who were referred for FNAC, were included in this study. FNAs of 17 patients were studied in the present study. FNAC was performed by using a 10 mL syringe with a 23 g needle. Smears were stained with H& E stain (Haematoxylin and Eosin)and ZN ( Ziehl –nelson )stain.The data collected was entered into an Excelsheet and analyzed. Results: Cytology slides prepared were studied, interpreted, and the diagnosis made was analyzed.A total of 17 cases were studied with the mean age of 6.24 months. Majority of the patients were males seen in 64.71% of cases. Ipsilateral Axillary lymphnode was the most common site involved seen in 82.35% cases.Pus was aspirated in 76.47% of cases.On microscopic examination diffuse necrosis with degenerated cellswas the predominant cytological pattern seen in nine (52.94%) cases. ZN stain showed Acid fast bacilli positivity in 15 cases. Conclusion: FNA cytology combined with clinical correlation is useful for diagnosis and management of BCG lymphadenitis.

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“…Tuberculosis (TB) is one of the most prevalent infectious diseases, and is the second cause of death due to infection. The most important ways to prevent tuberculosis are improving the socio-economic conditions, early diagnosis and treatment, chemical preventive measures for more susceptible groups and Bacillus Calmette-Guérin (BCG) vaccination (1). The vaccine stimulates the immune system of cells and thereby creates protection against TB infection.…”

Section: Introductionmentioning

confidence: 99%

Complications of Bacillus Calmette-Guérin Vaccination at a University Hospital in Iranian Neonates

Siroosbakht¹,

Rezakhaniha²

2018

J Compr Ped

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Background: The most common complications of Bacillus Calmette-Guérin (BCG) vaccine are lymphadenopathy, lymphadenitis, abscess, and fistula. These occur in less than one percent of vaccinated individuals. The aim of this study was to determine the frequency of these side-effects in Iranian neonates at a university hospital. Objectives: The researchers decided to study the new results of BCG vaccine complications at the university center and compare them with previous results from Iran and other countries until the relative position of Iran was identified. Methods: In a prospective, descriptive-analytical study with the census method, 214 neonates at Golestan Hospital of Tehran, Iran from May 2015 to Jan 2018 were studied. Bacillus Calmette-Guérin vaccination was performed for all these neonates at the hospital. The neonates were examined on a monthly basis by a physician and the questionnaires were completed. Results: In this study, the rate of lymphadenopathy, lymphadenitis, and fistulization of the abscess after BCG vaccination were 2.5%, 0.5%, and 0%, respectively. No significant difference was observed between gender and age of the infants and the occurrence of the complications (P > 0.05). Conclusions: This study showed a higher rate of lymphadenopathy and lymphadenitis after BCG vaccination compared with other studied countries. Various factors are involved in making this difference, such as inaccuracy in the injection site and injection method, improper dilution and type of vaccine manufacturer, and a more immunogenic vaccine (Pasteur Company, Tehran). Therefore, health authorities should help reduce the incidence of complications of BCG vaccination with continuous education of the vaccination unit personnel, monitoring the preservation and method of vaccine preparation and change of the vaccine strain.

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Children with lymphadenitis associated with Bacillus Calmette-Guérin (BCG) vaccination do not experience more infections when compared with BCG-vaccinated children without lymphadenitis: a three years paired-cohort in Mexico

Abstract: This cohort strongly suggests that BCG-LA in healthy children is not associated with more episodes of AINF and hospitalizations, when paired and compared with children BCG-vaccinated without BCG-LA.

Cited by 3 publications

References 14 publications

Incidence of Several Forms of Tuberculosis (TB) and Their Bacillus Calamette Guerin (BCG) Vaccination Status among Children

Incidence of Several Forms of Tuberculosis (TB) and Their Bacillus Calamette Guerin (BCG) Vaccination Status among Children

Fnac as a Tool in the Diagnosis of BCG Induced Lymphadenitis-an Institutional Experience.

Complications of Bacillus Calmette-Guérin Vaccination at a University Hospital in Iranian Neonates

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