Children with epilepsy after withdrawal of anticonvulsive therapy: psychiatric behaviour and neuropsychological abilities

Kölfen, Wolfgang; Edrich, J.; König, Stephan; Formanski, U.

doi:10.1007/s004310100792

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…They were, however, associated with IQ and SLQ scores. The prolonged seizure/febrile convulsions and the seizure frequency/AEDs components were significantly related to IQ, and the seizure In contrast to studies that found that seizure variables predict behavioral problems in children with epilepsy (1,4,9,10,(16)(17)(18), when independent seizure factors, cognition, language, and demographic factors are in the model, Verbal IQ is the most robust predictor of psychopathology in pediatric CPS. Similarly, Mitchell et al (23) found that seizure variables were unrelated to the 18month behavioral outcome of children with epilepsy by using structural equation modeling that included seizure, cognition, and demographic variables.…”

Section: Discussioncontrasting

confidence: 69%

“…Since then, several studies have shown that seizure‐related variables, particularly seizure control (2–10), type of seizure disorder (6,11–15), severity of seizure disorder (10,16–18), age at onset (4,19), duration of illness (4,20), AEDs (4,11,21–24), and focal EEG findings (6) are associated with psychopathology in children with epilepsy. When controlling for the effects of IQ, however, presence of a psychiatric diagnosis (7) and behavioral outcome (23) are unrelated to seizure variables in children with epilepsy.…”

mentioning

confidence: 99%

“…, age at onset (4,19), duration of illness (4,20), AEDs (4,11,(21)(22)(23)(24), and focal EEG findings (6) are associated with psychopathology in children with epilepsy. When controlling for the effects of IQ, however, presence of a psychiatric diagnosis (7) and behavioral outcome (23) are unrelated to seizure variables in children with epilepsy.…”

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confidence: 99%

“…As in psychopathology, different aspects of cognition are associated with seizure-related variables both in children with epilepsy who have mental retardation (25) [see review in (26)] and in children with normal intelligence (4,9,10,(27)(28)(29)(30)(31)(32)(33)(34). Nevertheless, only few studies examined the relation among psychopathology, IQ, and seizure-related variables in children with epilepsy.…”

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confidence: 99%

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Psychopathology and Pediatric Complex Partial Seizures: Seizure‐related, Cognitive, and Linguistic Variables

et al. 2004

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Summary:Purpose: This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence.Methods: One-hundred one CPS and 102 normal children, aged 5.1 to 16.9 years, had a structured psychiatric interview and cognitive and language testing. Parents provided demographic, perinatal, and seizure-related information, as well as behavioral information through the Child Behavior Checklist (CBCL) and a structured psychiatric interview about the child.Results: Significantly more CPS patients had psychopathology, cognitive deficits, and linguistic deficits than did those in the normal group. Among the patients, Verbal IQ predicted the presence of a psychiatric diagnosis, as well as CBCL scores in the borderline/clinical range. Seizure, linguistic, and demographic variables were unrelated to psychopathology. The cognitive and linguistic deficits of the CPS group, however, were predicted by seizure factors (e.g., prolonged seizures/febrile convulsions; seizure frequency/number of antiepileptic drugs) and demographic factors (e.g., minority status).Conclusions: Because subtle verbal cognitive deficits predict behavioral disturbances in pediatric CPSs, the study's findings highlight the importance of assessing behavior, cognition, and language in these children. They also underscore the negative impact of prolonged seizures, febrile convulsions, seizure frequency, and antiepileptic drug polytherapy on cognition and language in pediatric CPSs. Key Words: PsychopathologyCognition-Language-Complex partial seizure disorderChild.Hermann et al.(1) proposed a multifactorial model to delineate the mechanisms underlying behavioral disturbances in children with epilepsy. Relevant factors included seizure-related variables, such as type of seizure disorder, age at onset, duration of illness, EEG pattern, and neuropsychological status; antiepileptic drug (AED) variables, such as number of drugs and types of drugs; psychosocial variables, such as parents' marital status; and demographic variables, such as gender and median family income. They found that seizure control was the most powerful predictor of behavioral disturbances by using parent-based Child Behavior Checklist (CBCL) in 183 children with epilepsy, 53% with partial and 40% with primarily generalized epilepsy.Since then, several studies have shown that seizurerelated variables, particularly seizure control (2-10), type of seizure disorder (6,(11)(12)(13)(14)(15), severity of seizure disorder Accepted April 25, 2004. Address correspondence and reprint requests to Dr. R. Caplan at Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, U.S.A. E-mail: rcaplan@ucla.edu (10,(16)(17)(18), age at onset (4,19), duration of illness (4,20), AEDs (4,11,[21][22][23][24], and focal EEG findings (6) are associated with psychopathology in children with epilepsy. When controlling for the effects of IQ, however, presence of a psychiatric diagnosis (7) a...

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Section: Discussioncontrasting

confidence: 69%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Psychopathology and Pediatric Complex Partial Seizures: Seizure‐related, Cognitive, and Linguistic Variables

et al. 2004

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“…A number of epilepsy related factors appear to contribute to these problems including seizure frequency [18-21], recurrent seizures [5, 8, 20], age of seizure onset [13, 18, 22, 23], duration of illness [24, 25], antiepileptic drugs (AEDs) [19, 26, 27], type of epilepsy [1, 3, 15, 28], and focal EEG findings [7, 15, 29]. However, across studies the findings inconsistently implicate these epilepsy related variables [13, 30-33].…”

Section: Introductionmentioning

confidence: 99%

Cognition, academic achievement, language, and psychopathology in pediatric chronic epilepsy: Short-term outcomes

Jones

Siddarth

Gurbani

et al. 2010

Epilepsy & Behavior

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Children with epilepsy and control children were followed over a two year interval. Comorbidities of epilepsy, often defined as problems related to IQ, academic achievement, language, and psychopathology, were evaluated prospectively. It was hypothesized that over time a) the presence of comorbidities would predict worse outcomes, and b) epilepsy variables would negatively impact comorbidities. The study included 39 children with complex partial seizures (CPS), 25 children childhood absence epilepsy (CAE), and 27 healthy children, aged 7.6-16.1 years. The findings were notable for stability over the interval in all three groups. Additionally, baseline seizure variables and change over the interval appear to play a role in IQ and math achievement scores of children with epilepsy with average IQ and in the reading achievement scores of those with below average IQ. However, seizures variables at baseline and follow-up were not predictors of DSM-IV diagnoses, depression, anxiety or behavioral problems.

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Mathematics Skills in Epilepsy: A Systematic Review and Meta-Analysis

Poole,

Phillips,

Killer

et al. 2023

Neuropsychol Rev

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Mathematics incorporates a broad range of skills, which includes basic early numeracy skills, such as subitizing and basic counting to more advanced secondary skills including mathematics calculation and reasoning. The aim of this review was to undertake a detailed investigation of the severity and pattern of early numeracy and secondary mathematics skills in people with epilepsy. Searches were guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Twenty adult studies and 67 child studies were included in this review. Overall, meta-analyses revealed significant moderate impairments across all mathematics outcomes in both adults (g= -0.676), and children (g= -0.593) with epilepsy. Deficits were also observed for specific mathematics outcomes. For adults, impairments were found for mathematics reasoning (g= -0.736). However, two studies found that mathematics calculation was not significantly impaired, and an insufficient number of studies examined early numeracy skills in adults. In children with epilepsy, significant impairments were observed for each mathematics outcome: early numeracy (g= -0.383), calculation (g= -0.762), and reasoning (g= -0.572). The gravity of impairments also differed according to the site of seizure focus for children and adults, suggesting that mathematics outcomes were differentially vulnerable to the location of seizure focus.

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Children with epilepsy after withdrawal of anticonvulsive therapy: psychiatric behaviour and neuropsychological abilities

Abstract: Children with epilepsy who remained without relapse after withdrawal from the anticonvulsive therapy did not show any psychiatric abnormalities and their performance was comparable to that of healthy control children, provided no risk factors were present.

Cited by 10 publications

References 15 publications

Psychopathology and Pediatric Complex Partial Seizures: Seizure‐related, Cognitive, and Linguistic Variables

Psychopathology and Pediatric Complex Partial Seizures: Seizure‐related, Cognitive, and Linguistic Variables

Cognition, academic achievement, language, and psychopathology in pediatric chronic epilepsy: Short-term outcomes

Mathematics Skills in Epilepsy: A Systematic Review and Meta-Analysis

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