Children With Cancer and HIV Infection

Abstract

Kaposi sarcoma and Burkitt lymphoma occurred more often in children with HIV. These children have a lower tolerance of chemotherapy, even when combined with HAART.

Linfoma no Hodgkin: excelentes resultados a expensas de elevada toxicidad del tratamiento

“…Igualmente, el virus de Epstein-Barr se ha relacionado con la mayoría de los casos de LNH en inmunodeficientes [13][14][15] . Desde el punto de vista clínico, son tumores agresivos que pueden presentarse como urgencias oncológicas (sín-drome de lisis tumoral, síndrome de compresión de vena cava superior o inferior, obstrucción de la vía aérea, obstrucción intestinal, taponamiento cardíaco secundario a derrame pleural) o de una forma más leve, dependiendo de su localización 1 .…”

Cancer in Youth Living With HIV (YLWHIV): A Narrative Review of the Access to Oncological Services Among YLWHIV and the Role of Economic Strengthening in Child Health

“…While the introduction of and increased access to ART increased survival, studies from South Africa in the post-ART era still find a higher risk (between 14 and 14 times) of developing cancer among YLWHIV ( 8 , 16 ). Additionally, a retrospective study in South Africa found that HIV-positive children with cancer were generally younger (average age 6 years) compared to HIV-negative patients with cancer (average age 6.5 years) ( 25 , 27 ). This study also reported higher mortality among HIV-positive children and that the ratio of living children who were cancer-free to the total of children in the respective category, was significantly smaller among HIV-positive participants.…”

Walking the thin line between malignancy and infectious disease: A case report

“…Through induction antiretroviral drugs can decrease the efficacy of cytotoxic drugs and through inhibition they increase their toxicity [24,25]. Despite this, there are no current guidelines on dose adjustment of HAART or chemotherapy drugs [24,26]. However, it seems reasonable to substitute zidovudine for another antiretroviral drug because of the added risk of bone marrow suppression.…”