Children with breakthrough varicella infection requiring hospitalization in Turkey (VARICOMP Study 2008–2013)

Dinleyici, Ener Çağrı; Kurugöl, Zafer; Kara, Ateş; Tezer, Hasan; Taş, Mehmet; Güler, Ekrem; Yasa, Olcay; Devrim, İlker; Çıftçı, Ergın; Özdemir, Halil; Somer, Ayper; Özen, Metehan; Şensoy, Gülnar; Dalgıç, Nazan; Alhan, Emre

doi:10.1016/j.vaccine.2015.06.029

Cited by 12 publications

(30 citation statements)

References 12 publications

(22 reference statements)

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“…Using data from an active surveillance project, Chaves et al 15 , reported 1 case of pneumonia among 1,661 breakthrough cases in children aged 1–14 years during 1997–2005 in the United States. Dinleyici et al 23 reported 4 cases of pneumonia among a total of 36 hospitalized breakthrough cases in children from 29 health care centers in Turkey; these cases were identified as part of a national prospective study on pediatric varicella hospitalizations during 2008–2013.…”

Section: Resultsmentioning

confidence: 99%

“…Seven articles described meningitis cases. Dinleyici et al 23 reported 9 breakthrough cases with meningitis/encephalitis in their study of pediatric varicella hospitalizations; no additional information was provided on these cases. In the review of national safety data of varicella vaccine in the United States 1995–2005, Chaves et al 10 , described 4 cases of meningitis associated with breakthrough varicella in children aged ≤12 years, 2 of whom had a CSF specimen positive for VZV by PCR, strain type not indicated.…”

Section: Resultsmentioning

confidence: 99%

“…One is the publication by Dinleyici et al 23 that reported 9 breakthrough cases with encephalitis/meningitis. Chaves et al 15 , reported 1 case of breakthrough varicella with encephalitis in a healthy 4 year-old in the study from the varicella active surveillance project.…”

Section: Resultsmentioning

confidence: 99%

“…Dinleyici et al 23 reported 1 breakthrough case with cerebellitis based on hospital surveillance data from Turkey, without additional details.…”

Section: Resultsmentioning

confidence: 99%

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Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review

Leung

Broder

Marin

2017

Expert Review of Vaccines

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INTRODUCTION Varicella vaccines are highly effective at preventing disease, but varicella may occur among vaccinated persons (termed breakthrough varicella). Breakthrough varicella is generally mild, but severe cases have been reported. The objective of this review is to describe severe breakthrough varicella. AREAS COVERED We conducted a systematic review of articles published during 1974–2016. A total of 34 articles were included in our review: 21 described breakthrough varicella with disseminated varicella-zoster virus (VZV) infection with other organ involvement in addition to skin (none among two-dose vaccinees); 9 described hospitalized breakthrough varicella without mention of other organ involvement in addition to skin (of which 2 reported 4 two-dose vaccinees); and 4 described both. A total of 52–60 unique breakthrough varicella cases with disseminated VZV infection with other organ involvement in addition to skin reported with the following complications, not mutually exclusive: pneumonia (n=8–9 cases), neurologic (n=18–24 cases), hematologic (n=10–11 cases), ocular (n=5 cases), renal (n=2 cases), hepatic (n=3 cases), secondary infection with bacteremia or sepsis (n=8 cases), and other complication (n=4 cases). There were 6 cases of fatal breakthrough varicella. EXPERT COMMENTARY With >31 million doses distributed annually worldwide since 2007, severe breakthrough varicella can occur but they appear to be uncommon.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Dinleyici et al 23 reported 1 breakthrough case with cerebellitis based on hospital surveillance data from Turkey, without additional details.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review

Leung

Broder

Marin

2017

Expert Review of Vaccines

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“…Aşılı yedi olgumuzun hepsi bir doz aşı ile aşılan-mış olup, ve bu hastalarda komplikasyon gelişmediği ve hastalığın klinik seyrinin daha hafif geçirildiği gözlenmiştir. Buna karşın ülkemizde 5 yıllık dönemi kapsayan çok merkezli bir çalışmada (VARICOMP Study 2008-2013) tek doz aşılı 36 olguda hastaneye yatış gerektiren suçiçeği enfeksiyonu bildirilmiştir (10).…”

Section: Discussionunclassified

Evaluation of Patients with Varicella Infection at a Tertiary Center after Application of Single Dose Varicella Vaccine According to National Immunization Program

Sütçü¹,

Acar²,

Cebeci³

et al. 2017

Çocuk Enf Derg

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Amaç: Sağlıklı bireylerde suçiçeği enfeksiyonu genellikle kendini sınırlayan selim bir hastalık olmakla birlikte nadiren ciddi komplikasyonlara ve mortaliteye yol açabilmek-tedir. Suçiçeği aşısı, ülkemizde 2013 yılından itibaren ulusal aşı programı kapsamında 12. ayda tek doz şeklin-de uygulanmaktadır. Bu çalışmada 2013-2015 yılları süresince suçiçeğine bağlı komplikasyon ve hastaneye yatış nedenleri araştırıldı. Gereç ve Yöntemler: Ulusal şemada tek doz uygulanan suçiçeği aşılama sonrası başvuran, öncesinde sağlıklı olduğu ifade edilen 88 suçiçeği olgusunun kayıtlarından hastalığın seyri, tedavisi ve prognozu ile ilgili veriler retrospektif olarak toplandı. Suçiçeği tanısı anamnez, döküntü-nün karakteristik tipi ve hastalığın klinik seyrine göre konuldu. Suçiçeğinin başlangıcından 14 gün içinde sekonder gelişen bakteriyel enfeksiyonlar ve hastaneye yatış gerektiren durumlar komplikasyon olarak kabul edildi. Bulgular: Hastaların başvuru yaş ortancası 62 ay (aralık 1-205 ay) olup 52'si (%59,1) erkekti. Hastaların yıllara göre dağılımına bakıldığında; 2013 yılında 15 (%17), 2014 yılında 18 (%20,5), 2015 yılında 55 (%62,5) olgu mevcuttu. Hastaların 7'sinde (%7,9) aşılama öyküsü olup bu hastalarda suçiçeği sonrası komplikasyon gelişmedi. Suçiçeğine bağlı komplikasyon oranı ise %23,9 idi. En sık komplikasyon %19.3 oranında sekonder bakteriyel enfeksiyon olarak saptandı. Olguların 3'ü primer suçiçeği, 1'i postenfeksiyöz ataksi, 1'i ensefalit ve 1'i ise kemik-eklem enfeksiyonu olmak üzere 6'sı yatırıldı. Hastaların 5'i yatan olmak üzere toplam 9'una (%10,2) asiklovir tedavisi verildi. Sonuç: Ülkemizde tek doz uygulanan suçiçeği aşıla-ma sonrası dönemde, komplikasyon ve hastaneye yatış oranlarını yansıtacak çok merkezli çalışmalara ihtiyaç duyulmaktadır. ( AbstractObjective: Varicella zoster is often a self-limiting infectious disease in previously healthy children, though; it rarely can cause serious complications and even mortality. VaricellaZoster Virus (VZV) vaccination has been applied at the age of 12 months according to national vaccination schedule since 2013. The aim of this study was to evaluate the complications and hospitalization rates of varicella infection after national vaccination program. Material and Methods: Patient files of 88 previously healthy children who attended with VZV infection after vaccination program were retrospectively analyzed. Data regarding the course of the disease, treatment strategies and prognosis were recorded. Diagnosis was performed according to history, the characteristic type of rash and clinical course of the disease. Secondary bacterial infections and other conditions requiring hospitalization within 14 days after initial diagnosis were accepted as complications. Results: Eighty eight patients (59.1% male) with median age of 62 months (range 1-205 months) were enrolled. When distribution of patients according to years is considered; there were 15 (17%) cases in 2013, 18 (20.5%) cases in 2014 and 55 (62.5%) cases in 2015. Seven patients (7.9%) had vaccination history. Tota...

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Projections of zoster incidence in Australia based on demographic and transmission models of varicella-zoster virus infection

Costantino

Gidding

Wood

2017

Vaccine

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Re-exposure to varicella infection is believed to delay the occurrence of herpes zoster (HZ), which has led to predictions of increased HZ following introduction of varicella vaccination programs. However, there is evidence of rising HZ rates before vaccination was introduced. Here, we explore a potential explanation for this effect through demographic change leading to reductions in varicella exposure and boosting in the context of Australia over the 20th century. To study this hypothesis, we integrated observed changes in Australian birth and age-specific death rates with a varicella transmission model. The model was then calibrated to age-specific pre-vaccination seroprevalence (1997-9) and hospitalization data (1993-2009). Model simulations predicted that declining birth rates led to a 50% reduction in varicella incidence over the 20th century. When combined with the impacts of an aging population, the simulations further suggested that HZ incidence should have increased by 50% over the 20th century. However, we found that after age-standardization, the residual increase in HZ due to reduced boosting was only about 8% over the 20th century. Results were also sensitive to the assumed duration of immunity to HZ and whether multiple HZ episodes were possible. Despite a strong predicted effect of demographic change on varicella incidence, our findings suggest that improved survival is the main contributor to any rise in HZ rates prior to vaccination in Australia. Removing survival effects through age-standardization is recommended when considering epidemiologic or model-based analysis of past trends in HZ.

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Children with breakthrough varicella infection requiring hospitalization in Turkey (VARICOMP Study 2008–2013)

Cited by 12 publications

References 12 publications

Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review

Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review

Evaluation of Patients with Varicella Infection at a Tertiary Center after Application of Single Dose Varicella Vaccine According to National Immunization Program

Projections of zoster incidence in Australia based on demographic and transmission models of varicella-zoster virus infection

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