Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes

Jyonouchi, Harumi; Geng, Lee; Streck, Deanna; Toruner, Gokce

doi:10.1016/j.jneuroim.2011.07.001

Cited by 61 publications

(52 citation statements)

References 44 publications

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“…Based on this information, we hypothesized that PBMo can be utilized as surrogates of BMDM cells, for assessing innate immune abnormalities and dysregulation in the neuroimmune network in ASD subjects. Consistent with our previous findings [15], we observed variable cytokine production profiles in ASD subjects. The most notable differences observed between ASD and control PBMo were the production of IL-1β, an inflammatory cytokine, and IL-10, a counterregulatory cytokine.…”

Section: Discussionsupporting

confidence: 93%

“…These studies found that clinical features indicating immune abnormalities are unlikely to be associated with specific pathogens, but are more likely to be associated with dysregulated innate immune responses [14][15][16]. Others also reported that under the LPS stimulated cultures, increases in production of certain cytokines by PBMCs, are associated with ASD severity in a total of 50 young ASD subjects [17].…”

Section: Introductionmentioning

confidence: 97%

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Interleukin-1β/Interleukin10 Ratio Produced by Monocytes as a Biomarker of Neuroinflammation in Autism

Jyonouchi¹,

Geng²,

Buyske³

2017

J Clin Cell Immunol

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Interleukin-1β/Interleukin10 Ratio Produced by Monocytes as a Biomarker of Neuroinflammation in Autism

Jyonouchi¹,

Geng²,

Buyske³

2017

J Clin Cell Immunol

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“…Developmental neurotoxicants and immune challenges have been linked to autistic behaviors following prenatal exposure typically occurring during the I and II trimester of pregnancy, respectively (Persico & Merelli, in press). Finally, an additional layer of pathophysiological complexity is conferred by the frequent involvement of other compartments outside the central nervous system, such as the immune and gastrointestinal (GI) systems (Jyonouchi et al, 2011;Wang & Kasper, 2014).…”

Section: Introductionmentioning

confidence: 99%

Urinaryp-cresol is elevated in young French children with autism spectrum disorder: a replication study

et al. 2014

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The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex-and age-matched controls (p50.05). This increase was limited to ASD children aged 8 years (p50.01), and not older (p ¼ 0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic, compulsive/repetitive behaviors (p50.05), although not with overall autism severity. These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.

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“…For example, both CCL2 and CCL7 (these genes are in our CNV-i group and interestingly have been described by others as having a link to autism [35]) were in the CNV-c gene set "Metal ion homeostasis". This gene set had genes from both types of CNVs (CNV-i and CNV-o).…”

Section: Gene Set % Overlap With Cellular Process Calculationmentioning

confidence: 63%

Ethanol/alcohol pathways along with immune, cation and development may play a role in autism spectrum disorder

Saxena

2013

J Med Disord

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Introduction: Autism spectrum disorder or ASD was studied via copy number variations or CNVs and via windows straddling LoGS loci. We found strong concordance between our prior findings relating to development. Further, alcohol pathways were discovered. Methods: CNVs previously described in autism were studied and use of pathway overlaps in deducing mechanism is described. Results: CNVs related to autism were split into those falling within LoGS loci windows and those outside. Those inside related to immune function while those outside to alcohol pathways. Further, the enrichment of genes within windows centered on the loci showed mechanistic insights into autism. Discussion: Our analysis provides a mechanistic framework to define detailed mechanisms underlying autism. The found ethanol/ alcohol pathways rank topmost in the analysis conducted and provide another mechanistic insight into autism. Further the CNVs that contain such alcohol dehydrogenase or detoxifying genes show a loss in copy number as we would predict because alcohol has been known to affect the developing brain.

show abstract

Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes

Cited by 61 publications

References 44 publications

Interleukin-1β/Interleukin10 Ratio Produced by Monocytes as a Biomarker of Neuroinflammation in Autism

Interleukin-1β/Interleukin10 Ratio Produced by Monocytes as a Biomarker of Neuroinflammation in Autism

Urinaryp-cresol is elevated in young French children with autism spectrum disorder: a replication study

Ethanol/alcohol pathways along with immune, cation and development may play a role in autism spectrum disorder

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