Children's toxicology from bench to bed - Drug-induced Renal Injury (4): Effects of nephrotoxic compounds on fetal and developing kidney

Suzuki, Masami

doi:10.2131/jts.34.sp267

Cited by 14 publications

(5 citation statements)

References 10 publications

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“…The juxtamedullary zone contained formed glomeruli surrounded by convoluted tubules. In agreement with the results of the present study, Suzuki [22] described the postnatal morphological maturation as centrifugal, that is, maturation proceeds from the inner cortex toward the periphery. Moreover, Seely [23] stated that the UBs induce condensation of the metanephric mesenchyme.…”

Section: Discussionsupporting

confidence: 92%

Postnatal Effect Of Acrylamide On Rat Renal Cortex And The Protective Effect Of Ginger (Zingiber Officinale Roscoe)

Moawad

Fattah

Ramadan

2019

Egyptian Journal of Histology

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Background: Acrylamide is toxic both in experimental animals and in humans. It is proved to be carcinogenic in rodents and considered by The International Agency for Research on Cancer as a probable human carcinogen. Medicinal plants have significant antioxidant properties. Ginger had the highest antioxidant activity among these plants. Aim of the work:To detect the histopathological effects of acrylamide on the kidneys in postnatal rats and to determine the possible protective effect of Ginger (Zingiber officinale Roscoe) as an antioxidant. Methods: The experimental pregnant rats were randomly divided into 3 groups: Group 1 (control group): these rats were preserved under normal condition of diet and water. Group 2 (acrylamide-treated group): acrylamide was orally administered to non-anesthetized rats by gastric intubation at a dose of 10 mg/kg/day. Group 3 (ginger-protected group): animals of this group were given the same dose of acrylamide as in group 2 followed by 1 ml of final aqueous extract of ginger (24 mg/ml) three times weekly. All the doses were administered from the 7th day of gestation and continued up to 21 days after delivery. Postnatal rats at the 2nd and 21st days were selected from each group and were scarified. Their kidneys were carefully dissected, removed and fixed in 10% formalin for histopathological and immunohistochemical examinations. Results: Maternal acrylamide administration disturbed the development of the renal cortex of the offsprings. Histological examination of acrylamide-treated, 2-day-old rats revealed degenerated glomeruli with lack of capillary tufts, disarrangement of podocytes and thickening of the parietal layers of Bowman's capsules. Moreover, the damage was evident in the primitive tubules. Examination of acrylamide-treated, 21-day-old rats showed congested glomerular capillaries, mesangial hypercellularity, vacuolations and darkly stained nuclei of the renal tubular epithelium, and extensive interstitial cellular infiltration and hemorrhage. Statistically, acrylamide-treated groups at both ages showed a highly significant decrease in the mean glomerular count, and the mean thickness of the cortex and the medulla as compared to their control groups. Moreover, the area percentage of renal NF-kβ protein expression showed a significant increase with acrylamide treatment. Ginger administration effectively restored most of the acrylamide-induced renal cortical damage. Conclusion: ginger administration effectively restored most of the acrylamide-induced renal cortical damage, suggesting that ginger supplement can play a protective role against acrylamide deleterious effects.

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Section: Discussionsupporting

confidence: 92%

Postnatal Effect Of Acrylamide On Rat Renal Cortex And The Protective Effect Of Ginger (Zingiber Officinale Roscoe)

Moawad

Fattah

Ramadan

2019

Egyptian Journal of Histology

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“…Interestingly, the unique neonatal renal physiology may theoretically protect the kidney from some nephrotoxicity. For example, certain drugs requiring renal tubular transport as an initial toxic pathway (e.g., aminoglycosides, vancomycin) may not achieve their “full” toxic potential, as in an older child, because of immature transport function [19]. Additionally, nephrotoxic medication taken during fetal life or during postnatal nephrogenesis could interfere with nephron generation, contributing to a particular magnitude of damage.…”

Section: Neonatal Nephrotoxic Akimentioning

confidence: 99%

Drug-induced acute kidney injury in neonates

Hanna

Askenazi

Selewski

2016

Current Opinion in Pediatrics

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Purpose of review Acute kidney injury (AKI) is an independent risk factor for morbidity and mortality in critically ill neonates. Nephrotoxic medication exposure is common in neonates. Nephrotoxicity represents the most potentially avoidable cause of AKI in this population. Recent findings Recent studies in critically ill children revealed the importance of recognizing AKI and potentially modifiable risk factors for the development of AKI such as nephrotoxic medication exposures. Data from critically ill children who have AKI suggests that survivors are at risk for development of chronic kidney disease. Premature infants are born with incomplete nephrogenesis and are at risk for chronic kidney disease (CKD). The use of nephrotoxic medications in the neonatal intensive care unit (NICU) is very common; yet the effects of medication nephrotoxicity on the short and long-term outcomes remains highly understudied. Summary The neonatal kidney is predisposed to nephrotoxic AKI. Our ability to improve outcomes for this vulnerable group depends on heightened awareness of this issue. It is important for clinicians to develop methods to minimize and prevent nephrotoxic AKI in neonates through a multi-disciplinary approach aiming at earlier recognition and close monitoring of nephrotoxin induced AKI.

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“…Gentamicin is currently used associated to ampicillin in human obstetrics for prophylaxis of neonatal infections related to group B streptococci [82]. Toxic effects on rat fetal kidneys have been determined at high doses [83] and in kidneys of children [84]. …”

Section: Antibiotic Therapy and Teratogenic Risk During Canine Andmentioning

confidence: 99%

Antibiotic Treatment of Dogs and Cats during Pregnancy

Rebuelto

Loza

2010

Veterinary Medicine International

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The use of pharmacological agents in pregnant females poses a major clinical challenge due to the marked physiological changes that may modify the pharmacokinetics of drugs and to the potential effects on the fetus. The purpose of this paper is to review briefly our knowledge on the use of antibacterial drugs during pregnancy and to provide information for the judicious selection of an antimicrobial treatment for use in pregnant bitches and queens. The risk to the fetus is a result of the ability of a drug to reach the fetal circulation and to produce toxic effects. The placenta functions as a barrier that protects the fetus due to the presence of transporters and metabolising enzymes; however, during pregnancy, the presence and activity of both enzymes and transporters may change. Antimicrobial agents that have been shown to be safe for use during pregnancy include betalactams, macrolides, and lincosamides. Pharmacotherapy during pregnancy in all species may affect adversely the developing fetus; therefore, it should be avoided when possible.

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Children's toxicology from bench to bed - Drug-induced Renal Injury (4): Effects of nephrotoxic compounds on fetal and developing kidney

Abstract: Design and interpretation of studies in fetuses and infants regarding renal toxicity should include careful consideration of the state of renal development and maturation and of the mechanisms of renal injury.

Cited by 14 publications

References 10 publications

Postnatal Effect Of Acrylamide On Rat Renal Cortex And The Protective Effect Of Ginger (Zingiber Officinale Roscoe)

Postnatal Effect Of Acrylamide On Rat Renal Cortex And The Protective Effect Of Ginger (Zingiber Officinale Roscoe)

Drug-induced acute kidney injury in neonates

Antibiotic Treatment of Dogs and Cats during Pregnancy

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