Children's and Adult Involuntary and Occupational Exposures and Cancer

Colacci, Annamaria; Vaccari, Monica

doi:10.1002/9781119023647.ch8

Cited by 4 publications

(4 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer development has been associated with chemical exposure since Sir Percival Pott described, in 1775, the occurrence of scrotum cancer in chimney sweepers [ 1 , 2 ]. This first observation paved the way to the discovery of several classes of chemicals acting as carcinogens in human, most (but not all) of which have been demonstrated to act through genotoxic mechanisms, involving a direct damage to DNA [ 2 ]. At the beginning of the 21st century, the identification of cancer hallmarks added new perspectives in the understanding of cancer onset and development, following chemical exposure.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

Pillo

Mascolo

Zanzi

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

The Transformics Assay is an in vitro test which combines the BALB/c 3T3 Cell Transformation Assay (CTA) with microarray transcriptomics. It has been shown to improve upon the mechanistic understanding of the CTA, helping to identify mechanisms of action leading to chemical-induced transformation thanks to RNA extractions in specific time points along the process of in vitro transformation. In this study, the lowest transforming concentration of the carcinogenic benzo(a)pyrene (B(a)P) has been tested in order to find molecular signatures of initial events relevant for oncotransformation. Application of Enrichment Analysis (Metacore) to the analyses of the results facilitated key biological interpretations. After 72 h of exposure, as a consequence of the molecular initiating event of aryl hydrocarbon receptor (AhR) activation, there is a cascade of cellular events and microenvironment modification, and the immune and inflammatory responses are the main processes involved in cell response. Furthermore, pathways and processes related to cell cycle regulation, cytoskeletal adhesion and remodeling processes, cell differentiation and transformation were observed.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

Pillo

Mascolo

Zanzi

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Fresh combustion-generated particles presumably retain their particle form after deposition, whereas secondary particles, including concentrated aqueous solutions, dissolve into the lung surfactant, delivering dissolved chemicals and sometimes releasing an ultrafine primary core. The release of chemicals is facilitated by the greater specific surface area of fine particles (Colacci and Vaccari, 2017).…”

Section: Pm and The Receptors Interplaying In Adverse Outcomes By Chementioning

confidence: 99%

The Secretive Liaison of Particulate Matter and SARS-CoV-2. A Hypothesis and Theory Investigation

et al. 2020

Self Cite

View full text Add to dashboard Cite

“…Studies indicate that exposure levels have increased in recent years, particularly in rapidly industrializing countries (Landrigan et al, 2018). Management of risks associated with air pollution, however, remains challenging, even in countries where advanced technologies and environmental policies are in place (Colacci and Vaccari, 2017).…”

Section: Introductionmentioning

confidence: 99%

Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model

Serra

Vaccari

Mascolo

et al. 2019

ALTEX

View full text Add to dashboard Cite

perimental animals (IARC, 2016). Epidemiological studies have demonstrated a clear association between lifetime exposure to PM and lung cancer (Gharibvand et al., 2017;Hamra et al., 2014). This evidence is supported by strong mechanistic data, demonstrating the induction of mutagenic and genotoxic effects in humans and experimental systems (IARC, 2016). Moreover, PM also can play a role in the non-genotoxic origin of cancer, through the induction of oxidative stress-sustained inflammation (IARC, 2016).Difficulties in the risk assessment of human exposure to air pollution arise due to knowledge gaps in identifying multiple components of complex mixtures, the lack of toxicological information regarding their carcinogenic potential, and the limited approach to cumulative risk assessment from multiple exposures via multiple routes.

show abstract

Children's and Adult Involuntary and Occupational Exposures and Cancer

Cited by 4 publications

References 144 publications

Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

The Secretive Liaison of Particulate Matter and SARS-CoV-2. A Hypothesis and Theory Investigation

Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model

Contact Info

Product

Resources

About