Children and adolescents’ health-related quality of life in relation to eczema, asthma and hay fever: results from a population-based cross-sectional study

Matterne, Uwe; Schmitt, Jochen; Diepgen, Thomas L.; Apfelbacher, Christian

doi:10.1007/s11136-011-9868-9

Cited by 42 publications

(43 citation statements)

References 59 publications

(64 reference statements)

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“…Compared with previous studies that measured general HRQoL in children with adverse health conditions and diseases [18], [19], the variance explained of HRQoL was acceptable. However, the amount of variance explained suggests that factors that contribute to HRQoL in children are lacking in our model.…”

Section: Discussioncontrasting

confidence: 76%

Pediatric Health-Related Quality of Life: A Structural Equation Modeling Approach

et al. 2014

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ObjectivesOne of the most referenced theoretical frameworks to measure Health Related Quality of Life (HRQoL) is the Wilson and Cleary framework. With some adaptions this framework has been validated in the adult population, but has not been tested in pediatric populations. Our goal was to empirically investigate it in children.MethodsThe contributory factors to Health Related Quality of Life that we included were symptom status (presence of chronic disease or hospitalizations), functional status (developmental status), developmental aspects of the individual (social-emotional) behavior, and characteristics of the social environment (socioeconomic status and area of education). Structural equation modeling was used to assess the measurement structure of the model in 214 German children (3–5 years old) participating in a follow-up study that investigates pediatric health outcomes.ResultsModel fit was χ2 = 5.5; df = 6; p = 0.48; SRMR = 0.01. The variance explained of Health Related Quality of Life was 15%. Health Related Quality of Life was affected by the area education (i.e. where kindergartens were located) and development status. Developmental status was affected by the area of education, socioeconomic status and individual behavior. Symptoms did not affect the model.ConclusionsThe goodness of fit and the overall variance explained were good. However, the results between children' and adults' tests differed and denote a conceptual gap between adult and children measures. Indeed, there is a lot of variety in pediatric Health Related Quality of Life measures, which represents a lack of a common definition of pediatric Health Related Quality of Life. We recommend that researchers invest time in the development of pediatric Health Related Quality of Life theory and theory based evaluations.

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Section: Discussioncontrasting

confidence: 76%

Pediatric Health-Related Quality of Life: A Structural Equation Modeling Approach

et al. 2014

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“…Due to their high and significant intercorrelation (for instance between HADS-A and HADS-D r = 0.57, p < 0.001) the effects could not be replicated in multivariable analysis (only anxiety remained a significant correlate), but a relationship between chronic pruritus and a general psychosocial factor can be assumed. The design of the current study does not permit the establishment of any causal direction, but similar to how psychosocial factors are involved in eczema, influences in both directions are possible and likely (34)(35)(36). Future prospective studies may be able to analyse the conditions of how and when psychosocial factors influence chronic pruritus and/or vice versa.…”

Section: Cross-sectional Associationsmentioning

confidence: 99%

Incidence and Determinants of Chronic Pruritus: A Population-based Cohort Study

Matterne¹,

Apfelbacher²,

Vogelgsang³

et al. 2013

Acta Derm Venerol

127

121

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Epidemiological data on chronic pruritus (> 6 weeks) in the general population are sparse. We aimed to provide data on the incidence and prevalence of chronic pruritus, and identify its determinants based on cross-sectional and longitudinal analyses. A cohort of 1,190 participants from a cross-sectional baseline-study (response rate: 57.8%) was followed up after one year. The questionnaire assessed occurrence of chronic pruritus, medical, lifestyle and psychosocial variables. Incident chronic pruritus was defined as reported chronic pruritus at follow-up in those subjects free-of-the-symptom at baseline. Cross-sectional analyses of data from the follow-up assessments addressed potential associations of medical, lifestyle and psychosocial factors with prevalent chronic pruritus. Longitudinal analyses examined sociodemographic factors as potential predictors of incident chronic pruritus. The follow-up response rate was 83.1%. The mean age of subjects was 56 years, and 58% were female. The 12-month cumulative-incidence equalled 7.0% (95% confidence interval (95% CI) 5.2-9.2%. Lifetime prevalence was 25.5% (95% CI 21.8-27.8%). Incidence was significantly associated with age. Determinants of prevalent chronic pruritus in multi-variable analyses were: liver disease, asthma, eczema and dry skin within the medical domain, an elevated body mass index within the lifestyle domain and higher anxiety scores within the psychosocial domain. Findings suggest a considerable 12-month incidence and lifetime prevalence and provide important directions for future research.

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“…However, this number might overestimate the prevalence, as the answers were derived from self-responses. Quality of life is reduced in children and adolescents suffering from asthma [4]. The patients often have a limited ability to participate in physical activities and are not able to sleep through the night [5].…”

Section: Introductionmentioning

confidence: 99%

Influence of subcutaneous specific immunotherapy on drug costs in children sufferingfrom allergic asthma

Reinhold

Ostermann

Thum-Oltmer³

et al. 2013

Clinical & Translational All

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BackgroundSubcutaneous specific immunotherapy (SCIT) is an effective treatment attenuating the progression of allergic asthma. To date, there is a lack of studies investigating the economic consequences of SCIT on health care expenditures.MethodsA health-economic piggy-back analysis of SCIT was conducted based on a RCT that enrolled 65 children and adolescents with allergic asthma. Patients were allocated into two groups: A group receiving SCIT with a high-dose hypoallergenic house dust mite preparation plus asthma medication and a control group receiving only asthma medication. For both groups asthma control was achieved before the start of the SCIT treatment and was maintained during the study. Both, costs and cost-effectiveness of SCIT with the high-dose hypoallergenic house dust mite preparation were investigated based on total medication costs, incremental medication costs and treatment effects (measured as lung function), respectively. A bootstrap analysis was performed to validate the results.ResultsA steady decline in medication costs could be observed in the SCIT group one year after treatment start compared to the control group. This cost trend became statistically significant 3 years after SCIT started. The calculated potential savings in the SCIT group correlated with an improved lung function. The distribution of the bootstrap results revealed that the probability of SCIT having a superior effectiveness compared to the control group is around 90%.ConclusionSCIT with a high-dose hypoallergenic preparation received by children and adolescents suffering from mite induced allergic asthma reduces the allergic medication intake and has cost-saving effects. Additional costs associated with SCIT may be completely compensated by drug cost savings 4 years after end of SCIT. Additionally, SCIT is superior compared to routine care as measured by the lung function that improved in SCIT-treated patients. Trial registration: (EudraCT no. 2004 – 003892 – 35).

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Children and adolescents’ health-related quality of life in relation to eczema, asthma and hay fever: results from a population-based cross-sectional study

Cited by 42 publications

References 59 publications

Pediatric Health-Related Quality of Life: A Structural Equation Modeling Approach

Pediatric Health-Related Quality of Life: A Structural Equation Modeling Approach

Incidence and Determinants of Chronic Pruritus: A Population-based Cohort Study

Influence of subcutaneous specific immunotherapy on drug costs in children sufferingfrom allergic asthma

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