Childhood vitiligo

Prćić, Sonja; Duran,; Poljacki, M

doi:10.2298/mpns0212475p

Cited by 22 publications

(6 citation statements)

References 8 publications

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“…One hundred and twenty eight (17%) vitiligo patients were considered to have a family history and 28 (4.2%) cases have other auto-immune diseases. Patients were considered to have early onset vitiligo (n = 384, 61.4%) if the age of onset was prior to 20 years old [25].…”

Section: Resultsmentioning

confidence: 99%

Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People

Zhang

et al. 2011

PLoS ONE

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BackgroundVitiligo is a chronic depigmented skin disorder with regional melanocytes depletion. The pathogenesis was not completely clarified. Recently, more and more evidence suggested that polymorphisms of some genes are associated with vitiligo risk. Here, we want to examine the association between the inducible nitric oxide synthase (iNOS) gene polymorphisms and the risk of vitiligo in Chinese populations.Methods and Principal FindingsIn a hospital-based case-control study of 749 patients with vitiligo and 763 age- and sex-matched healthy controls, three polymorphisms of iNOS gene were genotyped by using the PCR-restriction fragment length polymorphism (PCR-RFLP) and mutagenically separated PCR (MS-PCR) methods, respectively. We found the iNOS-954 polymorphism was associated with a significantly higher risk of vitiligo (adjusted OR = 1.36, 95% CI = 1.02–1.81). Furthermore, this association is more pronounced in vulgaris vitiligo, active vitiligo and vitiligo without other autoimmune diseases in the stratification study. Analysis of haplotypes showed increased risk for the C -1173 C -954 CEx 16+14 (OR = 1.44, 95% CI = 1.01–1.74). In addition, the serum iNOS activity is significantly associated with iNOS-954 combined genotype (GC+CC) and is much higher in vitiligo patients than in the controls (P<0.01). Logistic regression analysis of iNOS activity showed increased risk between higher activity and iNOS-954 G→C variant genotype carriers (Ptrend<0.001).Conclusions and Significance INOS gene polymorphisms may play an important role in the genetic susceptibility to the development of vitiligo.

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Section: Resultsmentioning

confidence: 99%

Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People

Zhang

et al. 2011

PLoS ONE

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“…A positive family history of thyroid disease has been described in 32% to 43% of children with vitiligo, but in our study, no significant difference was observed in the family history of vitiligo in either group. 12 , 19 A positive family history for the premature greying of hairs is more common in the prepubertal vitiligo group.…”

Section: Discussionmentioning

confidence: 99%

Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients

Khurrum

AlGhamdi

2017

An. Bras. Dermatol.

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BackgroundThe onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs.ObjectiveTo compare the clinical profile of pre and postpubertal onset vitiligo.MethodsA cross-sectional observational study was conducted. The Vitiligo European Task Force questionnaire was completed for each patient.ResultsA total of 375 patients were included; 199 had postpubertal vitiligo (>12 years), and 176 had prepubertal onset vitiligo (<12years). There were more females in the prepubertal group (49%) than in the postpubertal group (29%), p-value <0.001. The prepubertal group has had more involvement than the postpubertal group (45% vs 30%, p=0.004). Only 8 cases of segmental vitiligo were observed; five were observed in the prepubertal group of patients. Female gender (OR=2.3; 95% CI:1.5, 3.5), presence of halo nevus (OR=2.2; 95% CI:1.1, 4.4) and face involvement (OR=1.9; 95% CI:1.2, 2.9) were positively associated with prepubertal vitiligo. Stress, as an onset factor, was positively associated (OR=0.51; 95% CI:0.3, 0.8) with postpubertal onset vitiligo.Study limitationsA possible selection bias toward more severe vitiligo cases can be a limitation, because the study was conducted in a clinic specialized in vitiligo. Moreover, a likelihood of false recall bias cannot be excluded.ConclusionsOur data present clinical evidence that vitiligo behaves mostly the same way in the prepubertal group as in the postpubertal group. However, female over-representation, more face involvement and more halo nevi were observed in prepubertal vitiligo, while stress was more prevalent as an aggravating factor in postpubertal vitiligo patients.

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“…Patients whose age of onset was earlier than 20 years were considered to have early-onset vitiligo (n = 598, 59Á8%). 35 In addition, there were 27 (2Á7%) patients with vitiligo accompanied by autoimmune disease, including four cases of psoriasis, eight cases of hyperthyroidism, five cases of alopecia areata, five cases of rheumatoid arthritis, one case of scleroderma, three cases of atopic dermatitis and one case of diabetes mellitus.…”

Section: Characteristics Of Study Subjectsmentioning

confidence: 99%

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

et al. 2014

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SummaryBackground Recent evidence has revealed an elevation of total homocysteine (tHcy) in patients with vitiligo. Methylenetetrahydrofolate reductase (MTHFR) is one of the main enzymes regulating homocysteine (Hcy) metabolism. Thus, polymorphisms of MTHFR could potentially contribute to the development of vitiligo by affecting MTHFR activity and tHcy levels. Objectives To evaluate the potential association between MTHFR polymorphisms and vitiligo susceptibility. Methods In total, 1000 patients with vitiligo and 1000 age-and sex-matched controls were enrolled in this hospital-based case-control study. Two single-nucleotide polymorphisms of the MTHFR gene (rs1801133 C>T and rs1801131 A>C) were selected and genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR, respectively. The MTHFR activity concentration and tHcy level in serum were measured by enzyme-linked immunosorbent assay. Results We found that allele T of rs1801133 in the MTHFR gene was associated with a significantly reduced risk of vitiligo (adjusted odds ratio 0Á58, 95% confidence interval 0Á43-0Á76, P < 0Á001). In addition, the patients with vitiligo had a lower activity concentration of MTHFR and higher level of tHcy than the controls. Correlation between these markers and the risk of vitiligo was also observed. Furthermore, the individuals with a no-risk genotype (CT + TT) of rs1801133 and higher activity concentration of MTHFR or lower level of tHcy had a significantly decreased risk of vitiligo. Conclusions Our data suggest that MTHFR gene polymorphisms may play a vital role in genetic susceptibility to vitiligo.

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Childhood vitiligo

Abstract: Our results show that segmental vitiligo and halo nevi occurred significantly more often in children than adults with vitiligo.

Cited by 22 publications

References 8 publications

Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People

Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People

Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

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