Childhood tuberculosis outbreak in Africa: is it a matter of concern?

Rai, Anushree; Aderinto, Nicholas; Abbass, Mortada; Uweis, Lama; Arab, Sara; Saleh, Rayyan El; Uwishema, Olivier; Masunga, Daniel Stephen; Nazir, Abubakar

doi:10.1097/js9.0000000000000140

Cited by 2 publications

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“…Based on WHO reports in 2017, the TB incidence rate in Indonesia is 391 per 100,000 population and the death rate is 42 per 100,000 population [5]. The proportion of child TB cases among all TB cases in Indonesia in 2013 was 7.9%; 7.16% in 2014; 9% in 2015 and increased to 10.62% in 2018 [1, [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Analysis Of The Nutritional Status Of Pediatric Tuberculosis Patients After Treatment At The X General Hospital Center

Rayhana,

Shabariah,

Anandita

2024

SHS Web Conf.

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Introduction: Indonesia is currently ranked 2nd in the country with the highest number of tuberculosis (TB) cases. TB disease in children cannot be separated from the role of nutritional status. Poor nutrition can cause immunological disorders and affect the disease healing process. Methodology: The research method used was cross-sectional which was carried out at Central General Hospital X in July 2019. A sample of 72 pediatric tuberculosis patients was taken using a simple random sampling technique. The data used is secondary data from medical records for the period January 2016-December 2018 to look at the characteristics of pediatric TB patients and analyze the evaluation of nutritional status after treatment. Data analysis used the non-parametric Wilcoxon test. Results: The highest age was in the 5-14 year category (51.4%). In the Wilcoxon test, a p-value of 0.000 (<0.05) was obtained, which stated that there was a significant difference between nutritional status before and after treatment. Conclusion: Compliance with pediatric TB patients in undergoing treatment will improve the patient’s nutritional status.

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Section: Introductionmentioning

confidence: 99%

Analysis Of The Nutritional Status Of Pediatric Tuberculosis Patients After Treatment At The X General Hospital Center

Rayhana,

Shabariah,

Anandita

2024

SHS Web Conf.

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“…This region alone contributes to 23% of new cases and 31% of TB-related deaths [6][7][8]. Moreover, about one-third (322,000) of the global TB cases of children (aged 0-14 years) were contributed from the African region; with two-thirds being unreported or undiagnosed [6,9]. In Ethiopia, TB remains a major public health concern.…”

Section: Introductionmentioning

confidence: 99%

Incidence rate of tuberculosis among HIV infected children in Ethiopia: systematic review and meta-analysis

Girma,

Abita,

Shifera

et al. 2024

BMC Pediatr

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Background Tuberculosis is one the leading causes of death from a single infectious disease, caused by the bacillus mycobacterium tuberculosis. In Ethiopia, even though several primary studies have been conducted on the incidence of tuberculosis among HIV-infected children, the pooled incidence rate of tuberculosis among HIV-infected children (aged 0–14 years) is unknown. Therefore, the main objectives of this systematic review and meta-analysis are to estimate the pooled incidence rate of tuberculosis among HIV-infected children and its predictors in Ethiopia. Method International electronic databases such as PubMed, HINARI, Science Direct, Google Scholar, and African Journals Online were searched using different search engines. Quality of primary studies was checked using the Joanna Briggs Institute checklist. The heterogeneity of studies was tested using I-square statistics. Publication bias was tested using a funnel plot and Egger’s test. Forest plots and tables were used to present the results. The random effect model was used to estimate the pooled incidence of tuberculosis among children living with HIV. Result A total of 13 studies were included in this systematic review and meta-analysis. The pooled incidence of tuberculosis among HIV-infected children was 3.77 (95% CI: 2.83, 5.02) per 100-person-year observations. Advanced HIV disease (HR: 2.72, 95% CI: 1.9; 3.88), didn’t receive complete vaccination (HR: 4.40, 95% CI: 2.16; 8.82), stunting (HR: 2.34, 95% CI: 1.64, 3.33), underweight (HR: 2.30, 95% CI: 1.61; 3.22), didn’t receive Isoniazid preventive therapy (HR: 3.64, 95% CI: 2.22, 5.96), anemia (HR: 3.04, 95% CI: 2.34; 3.98), fair or poor antiretroviral therapy adherence (HR: 2.50, 95% CI: 1.84; 3.40) and didn’t receive cotrimoxazole preventive therapy (HR: 3.20, 95% CI: 2.26; 4.40) were predictors of tuberculosis coinfection among HIV infected children. Conclusion This systematic review and meta-analysis concluded that the overall pooled incidence rate of tuberculosis among HIV-infected children was high in Ethiopia as compared to the END TB strategy targets. Therefore, emphasis has to be given to drug adherence (ART and Isoniazid) and nutritional counseling. Moreover, early diagnosis and treatment of malnutrition and anemia are critical to reduce the risk of TB coinfection. Registration Registered in PROSPERO with ID: CRD42023474956.

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Childhood tuberculosis outbreak in Africa: is it a matter of concern?

Cited by 2 publications

References 11 publications

Analysis Of The Nutritional Status Of Pediatric Tuberculosis Patients After Treatment At The X General Hospital Center

Analysis Of The Nutritional Status Of Pediatric Tuberculosis Patients After Treatment At The X General Hospital Center

Incidence rate of tuberculosis among HIV infected children in Ethiopia: systematic review and meta-analysis

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