A total of 232 patients with paranoid schizophrenia who were in conditions of long-term social isolation (prison, forced treatment) were studied. A relationship has been established between non-suicidal selfharm and leading psychopathological changes within the framework of the underlying disease in such patients. It was found that at the beginning of the development of a procedural disease, non-suicidal auto-aggression is episodic, arising impulsively, at the height of psycho-emotional experiences. In the future, non-suicidal auto-aggression acquires the character of conscious actions within the framework of a pseudo-adaptive coping strategy, the consolidation of which in the form of a dominant behavior model is prevented by increasing procedural changes in the personality.