Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls

Souza-Queiroz, Julia; Boisgontier, Jennifer; Étain, Bruno; Poupon, Cyril; Duclap, Delphine; d’Albis, Marc-Antoine; Daban, Claire; Hamdani, Nora; Corvoisier, Philippe Le; Delavest, Marine; Bellivier, Frank; Guevara, Pamela; Leboyer, Marion; Henry, Chantal; Houenou, Josselin

doi:10.1016/j.jad.2016.04.038

Cited by 60 publications

(44 citation statements)

References 46 publications

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“…For example, a recent meta‐analysis in adults with a history of childhood trauma demonstrated that trauma cohorts exhibited smaller hippocampus and amygdala volumes bilaterally along with reduced grey matter in the right dorsolateral prefrontal cortex . In a sample of patients with BD and healthy controls, we found CTQ total scores to be negatively correlated with amygdala volumes, prefronto‐limbic functional connectivity and uncinate fractional anisotropy . Therefore, childhood trauma might alter the volume of and/or connectivity between brain areas that might be less sensitive to the potential effects of lithium salts.…”

Section: Discussionmentioning

confidence: 71%

Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders

Étain

Lajnef

Brichant‐Petitjean

et al. 2016

Acta Psychiatr Scand

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Objectives: Reliable predictors of response to lithium are still lacking in bipolar disorders (BD).However, childhood trauma has been hypothesized to be associated with poor response to lithium. Methods:We included 148 patients with BD, euthymic when retrospectively and clinically assessed for response to lithium and childhood trauma using reliable scales.Results: According to the "Alda scale", the sample consisted in 20.3% of excellent responders, 49.3% of partial responders and 30.4% of non-responders to lithium. A higher level of physical abuse significantly correlated with a lower level of response to lithium (p=0.009). As compared to patients not exposed to any abuse, patients with at least two trauma abuses (emotional, physical or sexual) were more at risk of belonging to the non-responders group (OR=4.91 95CI(1.01-27.02)). Among investigated clinical variables, lifetime presence of mixed episodes and alcohol misuse were associated to non-response to lithium. Multivariate analyses demonstrated that physical abuse and mixed episodes were independently associated with poor response to lithium (p=0.005 and p=0.013 respectively). Conclusions:Childhood physical abuse might be involved in a poor future response to lithium prophylaxis, this effect being independent of the association between clinical expression of BD and poor response to lithium.

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Section: Discussionmentioning

confidence: 71%

Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders

Étain

Lajnef

Brichant‐Petitjean

et al. 2016

Acta Psychiatr Scand

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“…Moreover, perceived rejection and other forms of long-term emotional trauma are often implicated in the alteration of brain chemistry (Ford & Russo, 2006). Beyond this, adults who reported having experienced childhood trauma, especially emotional abuse, had a reduced amygdala volume in comparison with normal controls who had no such experiences (Souza-Queiroz et al, 2016). Impaired functioning in this region of the brain creates a vulnerability to internalizing symptoms and produces exaggerated and generalized anxiety and emotional responses, thus predisposing individuals to mood and anxiety disorders (Birn, Patriat, Phillips, Germain, & Herringa, 2014).…”

Section: Neurobiological and Neuropsychological Correlates Of Rejectionmentioning

confidence: 99%

Deep Structure of the Human Affectional System: Introduction to Interpersonal Acceptance–Rejection Theory

Rohner

Lansford

2017

J of Family Theo & Revie

103

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Interpersonal acceptance–rejection theory (IPARTheory) proposes that across cultures and other sociodemographic groups, interpersonal acceptance and rejection consistently predict the psychological and behavioral adjustment of children and adults (Rohner, 1986, 2004). The goals of this article are to provide a description of the major tenets of IPARTheory, summarize findings from empirical tests of the theory, and suggest future directions tied to the other articles in this special collection as well as for the field moving forward.

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“…Cannabis use has been associated with reduced global and frontal lobe volumes (Welch et al, 2011), cortical thinning in general (Habets et al, 2011), and, more specifically, in dorso-lateral prefrontal cortex (DLPFC) and anterior cingulate cortex (Rais et al, 2010). Childhood adversity/trauma has been associated with global cortical thinning globally (Habets et al, 2011) and in the limbic system (Souza-Queiroz et al, 2016), as well as decreased subcortical structure volumes (Hoy et al, 2012;Barker et al, 2016a). So far, OC have not been significantly related to cortical thinning (Haukvik et al, 2009; but birth complications have been previously linked to reduced hippocampal and cortical volume (Cannon et al, 2002;van Erp et al, 2002) and may, alone or in accumulation with other risk factors, be linked to deficits in cortical thickness (CT).…”

Section: Introductionmentioning

confidence: 99%

Effects of environmental risks and polygenic loading for schizophrenia on cortical thickness

Neilson

Bois

Gibson

et al. 2017

Schizophrenia Research

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There are established differences in cortical thickness (CT) in schizophrenia (SCZ) and bipolar (BD) patients when compared to healthy controls (HC). However, it is unknown to what extent environmental or genetic risk factors impact on CT in these populations. We have investigated the effect of Environmental Risk Scores (ERS) and Polygenic Risk Scores for SCZ (PGRS-SCZ) on CT. Structural MRI scans were acquired at 3T for patients with SCZ or BD (n=57) and controls (n=41). Cortical reconstructions were generated in FreeSurfer (v5.3). The ERS was created by determining exposure to cannabis use, childhood adverse events, migration, urbanicity and obstetric complications. The PGRS-SCZ were generated, for a subset of the sample (Patients=43, HC=32), based on the latest PGC GWAS findings. ANCOVAs were used to test the hypotheses that ERS and PGRS-SCZ relate to CT globally, and in frontal and temporal lobes. An increase in ERS was negatively associated with CT within temporal lobe for patients. A higher PGRS-SCZ was also related to global cortical thinning for patients. ERS effects remained significant when including PGRS-SCZ as a fixed effect. No relationship which survived FDR correction was found for ERS and PGRS-SCZ in controls. Environmental risk for SCZ was related to localised cortical thinning in patients with SCZ and BD, while increased PGRS-SCZ was associated with global cortical thinning. Genetic and environmental risk factors for SCZ appear therefore to have differential effects. This provides a mechanistic means by which different risk factors may contribute to the development of SCZ and BD.

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Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls

Cited by 60 publications

References 46 publications

Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders

Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders

Deep Structure of the Human Affectional System: Introduction to Interpersonal Acceptance–Rejection Theory

Effects of environmental risks and polygenic loading for schizophrenia on cortical thickness

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