Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met

Bîlc, Mirela I.; Vulturar, Romana; Chiş, Adina; Buciuman, Mădălina; Nuţu, Daria; Bunea, Ioana; Szentágotai‐Tătar, Aurora; Miu, Andrei C.

doi:10.1016/j.neulet.2018.07.018

Cited by 14 publications

(5 citation statements)

References 43 publications

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“…Although the incidence of GG genotype for rs41423247 NR3C1:c.1184+646C>G is slightly higher in the MDD group, the OR for the dominant model is OR=1.13 (p=0.72), OR=1.86 for the recessive model (p=0.16) and OR=1.22 for the allelic model (p=0.33). [27], 19.26% [28], and 16.53% [29].…”

Section:  Resultsmentioning

confidence: 98%

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Association between genetic variants and depression in a Romanian cohort

Costache

Riza²,

Popescu³

et al. 2022

Rom J Morphol Embryol

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Major depressive disorder (MDD) is beyond doubt a common, disabling, and costly condition. MDD associates hypothalamic-pituitary-adrenal (HPA) axis alterations. We sought to investigate two candidate variants which could have a role in the genetic susceptibility for stress or corticoidinduced MDD: glucocorticoid receptor (GR) -nuclear receptor subfamily 3 group C member 1 (NR3C1) rs41423247 and brain-derived neurotrophic factor rs6265 BDNF:c.442G>A Val66Met. We enrolled 82 Romanian subjects, 1:2 male to female ratio, 53.54±8.98 years old, diagnosed with an episode of major depression at the Clinical Neuropsychiatry Hospital in Craiova, Romania, and 286 healthy controls, 34.28±16.34 years old. All subjects were genotyped using specific ThermoFisher Scientific assays on a ViiA™ 7 real-time polymerase chain reaction (PCR) system. The impact of certain genetic variants may be ethnic-specific. In our Romanian cohort, rs41423247 NR3C1:c.1184+646C>G has a minor allele frequency of 29.2%, and rs6265 BDNF:c.442G>A of 22.2%. Neither reached significance in our study, under any of the association models -dominant, recessive, or allelic. Interpretation of our negative findings requires caution: literature provides arguably more evidence for the association between the analyzed polymorphisms; our study has sample size challenges, from which refined phenotyping limitations derive.

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Section:  Resultsmentioning

confidence: 98%

“…In this case, MAFs for the control group was 22.2%, comparable to the EUR reported frequency. rs6265 BDNF:c.442G>A has been previously reported in healthy individuals of Romanian ethnicity having a MAF ranging from 22.18% [ 27 ], 19.26% [ 28 ], and 16.53% [ 29 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Association between genetic variants and depression in a Romanian cohort

Costache

Riza²,

Popescu³

et al. 2022

Rom J Morphol Embryol

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“…Looking at the literature, it is generally seen that there is a positive relationship between alexithymia and childhood traumas and emotion regulation difficulties. Studies are showing that emotion regulation difficulties may develop as a result of traumatic events [48,49]. It was concluded that there was a significant positive relationship between CTS and ERD sub-dimensions, and as CTS increased, ERD also increased [6,50].…”

Section: Discussionmentioning

confidence: 99%

“…The Turkish validity and reliability study of the scale was conducted by [48], and the internal consistency Cronbach alpha coefficient of the scale was found to be 0.93. Emotional abuse parameter was evaluated with items 3, 8, 14, 18, 25; physical abuse with items 9, 11, 12, 15, 17; emotional neglect with items 5, 7, 13, 19, 28; physical neglect with items 1, 4, 6, 2, 26; and sexual abuse with items 20, 21, 23, 24, 27 [48,49].…”

Section: Childhood Traumas Scale (Cts)mentioning

confidence: 99%

Examining the Relationship Between Childhood Traumas, Alexithymia and Emotional Regulation Difficulties in University Students

Akpinar

2024

Through Your Eyes - Research and New Perspectives on Empathy [Working Title]

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The aim of this study is to examine the relationship between childhood traumas, alexithymia, and difficulty in emotion regulation among university students. A relational screening approach was used in the research. A relational screening model was used in the research. The study sample group consists of 351 university students. 83.5% of the participants were women (n = 293) and 16.5% were men (n = 63). Informed Voluntary Consent Form, Sociodemographic Information Form, Childhood Trauma Scale, Toronto Alexithymia Scale and Emotion Regulation Scale Short Form were administered to the participants. Data collection was carried out online (Google Forms) through convenient sampling, examining the relationship and effect between nonparametric tests and sociodemographic characteristics, childhood traumas, alexithymia and emotion regulation difficulties by looking at normality curves in data analysis. As a result of the research findings, a significant and positive relationship was found between childhood traumas, alexithymia and emotion regulation difficulties of university students. In addition, it was determined that male individuals are more alexithymia than females, females are exposed to sexual abuse more than males, the 24–25 age group has more emotional dysregulation, and the rates of emotional dysregulation and alexithymia are low in the presence of a romantic relationship. It is thought that this study can contribute to the relevant literature.

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“…BDNF has a functional single-nucleotide polymorphism (SNP) known as Val66Met, which is shown to reduce the activity-dependent secretion of BDNF 50 . Studies have demonstrated that this SNP interacts with childhood adversity to affect cognition, emotion, and psychopathology [51][52][53][54][55] ; for example, it interacts with childhood maltreatment to influence the development and severity of depression 52,53 and PTSD 54 . This SNP has also been associated with attention bias 56,57 and circulating inflammatory markers 58,59 .…”

Section: Introductionmentioning

confidence: 99%

Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype

et al. 2021

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Childhood maltreatment has been associated with greater attention bias to emotional information, but the findings are controversial. Recently, a novel index of attention bias, i.e., attention bias variability (ABV), has been developed to better capture trauma-related attentional dysfunction. However, ABV in relation to childhood trauma has not been studied. Here, we examined the association of childhood maltreatment history with attention bias/ABV in 128 healthy adult women. Different types of childhood maltreatment were assessed with the Childhood Trauma Questionnaire. Attention bias/ABV was measured by the dot-probe task. Possible mechanisms whereby childhood maltreatment affects attention bias/ABV were also explored, focusing on blood proinflammatory markers and the BDNF Val66Met polymorphism. We observed a significant positive correlation between childhood emotional abuse and ABV (P = 0.002). Serum high-sensitivity tumor necrosis factor-α levels were significantly positively correlated with ABV (P < 0.001), but not with childhood maltreatment. Jonckheere–Terpstra trend test showed a significant tendency toward greater ABV with increasing numbers of the BDNF Met alleles (P = 0.021). A two-way analysis of variance further revealed that the genotype-by-emotional abuse interaction for ABV was significant (P = 0.022); individuals with the Val/Met and Met/Met genotypes exhibited even greater ABV when childhood emotional abuse was present. These results indicate that childhood emotional abuse can have a long-term negative impact on emotional attention control. Increased inflammation may be involved in the mechanism of ABV, possibly independently of childhood maltreatment. The BDNF Met allele may dose-dependently increase ABV by interacting with childhood emotional abuse.

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Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met

Cited by 14 publications

References 43 publications

Association between genetic variants and depression in a Romanian cohort

Association between genetic variants and depression in a Romanian cohort

Examining the Relationship Between Childhood Traumas, Alexithymia and Emotional Regulation Difficulties in University Students

Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype

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