Childhood to adult transition and long-term follow-up after blood and marrow transplantation

Cupit, Margaret Carlisle; Duncan, Christine; Savani, Bipin N.; Hashmi, Shahrukh K.

doi:10.1038/bmt.2015.228

Cited by 32 publications

(22 citation statements)

References 76 publications

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“…Previous reports have summarized many of the hardships faced by survivors of childhood and adolescent cancer as they age. 5–8 These include lack of follow-up care, long-term health sequelae, and psychosocial challenges.…”

Section: Introductionmentioning

confidence: 99%

Damocles’ syndrome revisited: Update on the fear of cancer recurrence in the complex world of today’s treatments and survivorship

Cupit-Link

Syrjala

Hashmi

2018

Hematology/Oncology and Stem Cell Therapy

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Objective/Background Improvements in curative treatments for many types of cancer have emerged over the past several decades, resulting in a growing population of long-term cancer survivors—of both adult and childhood cancers. Despite this incredible medical achievement, long-term survivors of cancer face a unique fear: the fear of relapse. Methods We conducted a review of the literature for data on fear of relapse among cancer survivors. Results The fear of cancer recurrence is present in survivors of childhood and adult cancers as well as family members and often leads to psychological sequelae. Conclusion Literature on the fear of cancer recurrence has begun to emerge. However, herein we provide a unique approach through the use of a metaphor: Cicero’s story of Damocles’ sword. We aim to outline the many fear-related and emotional challenges faced by cancer survivors with an extensive review of studies demonstrating such challenges.

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Section: Introductionmentioning

confidence: 99%

Damocles’ syndrome revisited: Update on the fear of cancer recurrence in the complex world of today’s treatments and survivorship

Cupit-Link

Syrjala

Hashmi

2018

Hematology/Oncology and Stem Cell Therapy

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“…BMT represents a viable therapeutic avenue in developed countries in spite of the associated risks, albeit the price of allogenic BMT exceeds $200 000 (in the United States). 159 The extent of infrastructure and resources required for BMT restricts its wide use in developing countries, 160,161 which have the highest prevalence of b-globin disorders. 162 …”

Section: -151mentioning

confidence: 99%

Customizing the genome as therapy for the β-hemoglobinopathies

Canver

Orkin

2016

Blood

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Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment options have lagged behind. Recent developments in technologies for facile manipulation of the genome (zinc finger nucleases, transcription activator-like effector nucleases, or clustered regularly interspaced short palindromic repeats–based nucleases) raise prospects for their clinical application. The use of genome-editing technologies in autologous CD34+ hematopoietic stem and progenitor cells represents a promising therapeutic avenue for the β-globin disorders. Genetic correction strategies relying on the homology-directed repair pathway may repair genetic defects, whereas genetic disruption strategies relying on the nonhomologous end joining pathway may induce compensatory fetal hemoglobin expression. Harnessing the power of genome editing may usher in a second-generation form of gene therapy for the β-globin disorders.

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“…Overall, the results underscore that survivors of allo-SCT in childhood need long-term surveillance, since new problems can arise over the course of time. This is probably best done in specialised survivorship clinics with the aim to optimise health and assist survivors in reaching their full potential (Cupit et al, 2016 , 2015) and this might also be effective for childhood cancer survivors.…”

Section: Discussionmentioning

confidence: 99%

“…This is probably best done in specialised survivorship clinics with the aim to optimise health and assist survivors in reaching their full potential (Cupit et al, 2016). This is probably best done in specialised survivorship clinics with the aim to optimise health and assist survivors in reaching their full potential (Cupit et al, 2016).…”

Section: Reference Group (N = 296) N (%) P-value Bmentioning

confidence: 99%

“…Today, there is a paucity of studies focusing on survivors of paediatric allo-SCT transition to adulthood (Cupit, Duncan, Savani, & Hashmi, 2016), which limits the knowledge about how these individuals manage as adults. An important part of being an adult is to be able to enter and stay in the labour market, and late effects due to allo-SCT may negatively influence participation in paid work, as shown among adult survivors of allo-SCT (De Boer et al, 2015;Winterling et al, 2014).…”

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confidence: 99%

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Occupational status among adult survivors following allogeneic stem cell transplantation in childhood

et al. 2018

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This study examined occupational status and factors associated with sick leave and disability pension among adult long-term survivors previously treated with allogeneic stem cell transplantation (allo-SCT) during childhood. Moreover, occupational status was compared to that of a reference group. Data were collected with questionnaires and from medical records. The SCT group included 59 adults (18-45 years old: response rate 63%) treated with allo-SCT in childhood with a median of 17 (range 3-28) years earlier. The reference group included 296 individuals randomly selected from the general population. The results show that 54% of the long-term survivors were working part- or full-time and that 19% were on sick leave or disability pension. A larger proportion of the SCT group was on sick leave or disability pension (19% vs. 6%: p < .001) than of the reference group. The logistic regression analysis revealed that being on sick leave or disability pension among long-term survivors was associated with late effects related to the allo-SCT (OR 12.28: 95% CI 1.3-111.6: p = .03). The results underscore that long-term survivors' engagement in paid work is influenced many years after treatment and highlights the need to include vocational assistance in the rehabilitation following allo-SCT in childhood.

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Childhood to adult transition and long-term follow-up after blood and marrow transplantation

Cited by 32 publications

References 76 publications

Damocles’ syndrome revisited: Update on the fear of cancer recurrence in the complex world of today’s treatments and survivorship

Damocles’ syndrome revisited: Update on the fear of cancer recurrence in the complex world of today’s treatments and survivorship

Customizing the genome as therapy for the β-hemoglobinopathies

Occupational status among adult survivors following allogeneic stem cell transplantation in childhood

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