Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience

Goldberg, John M.; Silverman, Lewis B.; Levy, Donna E.; Dalton, Virginia; Gelber, Richard D.; Lehmann, Leslie; Cohen, Harvey J.; Sallan, Stephen E.; Asselin, Barbara L.

doi:10.1200/jco.2003.10.116

Cited by 306 publications

(247 citation statements)

References 26 publications

Supporting

Mentioning

224

Contrasting

Unclassified

Order By: Relevance

“…Five-year survival rates (FSR) for children and adolescents with this disease are 75-85%, whereas, adult T-ALL patients have a 35-40% FSR. T-ALL patients have essentially the same FSR of patients with B-ALL (Goldberg et al, 2003). However, certain aspects about T-ALL make it a more aggressive disease with a poorer clinical outcome than B-ALL.…”

Section: Introductionmentioning

confidence: 79%

“…Approximately 5200 new cases of leukemia will be classified as ALL in 2008 (http://www.leukemia-lymphoma.org). T-ALL accounts for approximately 10-15% and 25% of ALL cases in children and adults, respectively (Thiel et al, 1989;Goldberg et al, 2003;Pui et al, 2004). Over the past 20 years, mortality rates for leukemia (all subtypes, collectively) have remained relatively the same (http://www.cancer.gov).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

It's T-ALL about Notch

2008

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

It's T-ALL about Notch

2008

View full text Add to dashboard Cite

“…Patients with T-cell ALL have a higher incidence of induction failure and CNS relapse [15,38]. Compared with precursor B-cell ALL, the prognostic markers for T-cell ALL are relatively inadequate for treatment planning.…”

Section: Discussionmentioning

confidence: 99%

Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T‐cell acute lymphoblastic leukemia

Yang

Hsiao

Chen

et al. 2011

Pediatric Blood & Cancer

View full text Add to dashboard Cite

BackgroundThe absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T‐cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T‐cell ALL.ProcedureForty‐five children with T‐cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q‐PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q‐PCR was defined as a fold‐change <0.35.ResultsABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P = 0.03; hazard ratio [HR] = 8.13; 95% confidence interval [95% CI] = 1.23–53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P = 0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P = 0.036; HR = 4.25; 95% CI = 1.10–16.42).ConclusionsThe absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T‐cell ALL in Taiwan. Providing patients with T‐cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. Pediatr Blood Cancer 2012; 58: 846–851. © 2011 Wiley Periodicals, Inc.

show abstract

“…Patients with T-ALL have significantly higher rates of induction failure, early relapse and a shorter median time to relapse compared to B-ALL [3]. Relapses in leukemia occur most commonly in the bone marrow followed by CNS and the testes.…”

Section: Discussionmentioning

confidence: 99%

Bone Relapse in T Lineage Acute Lymphoblastic Leukemia in a Child: A Case Report and Review of Literature

Meena¹

2017

Arch Med

View full text Add to dashboard Cite

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. T-cell ALL accounts for 10% to 15% of cases. Acute lymphoblastic leukemia can rarely relapse in unusual extra medullary sites like bone. Hereby, we report a case of 7-years old male child presented with left arm swelling, initially confused with bone tumor but later found to be infiltration by leukemic blasts. We reviewed all previous cases and suggest that in a patient of ALL presenting with a bone swelling during or after completion of therapy, one should suspect of bone relapse.

show abstract

Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience

Cited by 306 publications

References 26 publications

It's T-ALL about Notch

It's T-ALL about Notch

Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T‐cell acute lymphoblastic leukemia

Bone Relapse in T Lineage Acute Lymphoblastic Leukemia in a Child: A Case Report and Review of Literature

Contact Info

Product

Resources

About