Childhood steroid-sensitive nephrotic syndrome: Does the histology matter?

Webb, Nicholas J.A.; Lewis, Malcolm; Iqbal, Javed; Smart, Philip; Lendon, M; Postlethwaite, R J

doi:10.1016/s0272-6386(96)90157-2

Cited by 32 publications

(23 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was found that there is no correlation between prebiopsy course and histology and also that steroid sensitivity rather than histological findings is the major determinant of the prognosis in childhood nephrotic syndrome [21,22]. In our study, the histological differences between the two groups were not statistically significant.…”

Section: Discussioncontrasting

confidence: 60%

Effect of Intrauterine Growth Retardation on the Progression of Nephrotic Syndrome

Yang

Choi

et al. 2002

Am J Nephrol

View full text Add to dashboard Cite

Background/Aim: Neonates with intrauterine growth retardation (IUGR) experience higher morbidity and mortality rates than appropriate-for-gestational-age (AGA) neonates. The purpose of our study was to clarify whether IUGR has any influences on the progression of nephrotic syndrome in children. Methods: We performed a retrospective review of 56 children with nephrotic syndrome. IUGR was defined as a birth weight less than the tenth percentile for gestational age. Among 56 patients having nephrotic syndrome, 8 had IUGR, and 48 were AGA. Results: The 24-hour urinary protein level in children with IUGR was significantly higher than that in children who were AGA (7.61 ± 6.75 vs. 3.92 ± 3.70 g/day, p < 0.05). There was a statistically significant difference in the incidence of steroid resistance (62.5 vs. 10.4%, p < 0.05) and in the time to remission (median 60 vs. 13 days, p < 0.05) between the children with IUGR and those being AGA. Also, there was a significant difference in the incidences of treatment with cytotoxic agents (75 vs. 29.2%, p < 0.05) and complications such as hypertension. Conclusions: Our report indicates that IUGR predicts an unfavorable progression of nephrotic syndrome. So, it is important for nephrologists to pay attention to the clinical course of nephrotic syndrome in neonates with IUGR.

show abstract

Section: Discussioncontrasting

confidence: 60%

Effect of Intrauterine Growth Retardation on the Progression of Nephrotic Syndrome

Yang

Choi

et al. 2002

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…12,13 There are currently a large number of effective therapeutic options for the management of NS, and the relative position of one against another is determined by the available scientific evidence and by the clinicians' experience.…”

mentioning

confidence: 99%

The long-term outlook to final outcome and steroid treatment results in children with idiopathic nephrotic syndrome

et al. 2015

View full text Add to dashboard Cite

Idiopathic Nephrotic Syndrome (INS) was defined as combination of a nephrotic syndrome and non-specific histological abnormalities of the kidney. Among these abnormalities, minimal change nephrotic syndrome (MCNS) is the most common. We report our experience with MCNS; its clinical course, treatments and outcomes. One-hundred twenty children (66 male, 54 female) with MCNS, admitted to Nephrology Department between 1987-2009 was assessed. Their clinical presentations, treatment and disease courses were reviewed. The mean duration of follow-up was 11.5 ± 1.9 years. Initially, all patients given prednisone 2 mg/kg/ day single dose per four weeks a followed by eight weeks of the same daily dose given every other day. After week 12, prednisone was progressively tapered off at the rate of 0.5 mg/kg per 15 daily intervals until complete discontinuation had been achieved by week 16. Steroid resistance was accepted as no achievement of remission following four weeks of prednisone 2 mg/kg/day followed by three intravenous pulses of corticosteroids. At the end of the initial steroid treatment, 106 (88.3%) patients were determinate steroid responsive while 14 (11.7%) patients were steroid resistance. Thirty-eight patients underwent biopsy. At the end of study recovery rate was increased from 88.3% to 94.1%. In conclusion, most of patients entered remission by our therapy end of follow up time. With the support of our satisfactory results among the whole study group, long-term prednisolone treatment still remains valid.

show abstract

“…Our results are similar with other study that the increasing incidence of mesangial proliferatve glomerulonephritis was limited to patients older than eight years of age. 14,15 It is well recognized that the diagnosis of FSGS in children with idiopathic nephrotic syndrome carries a poor prognosis. 16,17 Although initially considered a resistant lesion, recent data suggest that more aggressive therapies can induce a response in more than 50% of patients.…”

Section: Discussionmentioning

confidence: 99%

Renal Histopathology in Childhood Nephrotic Syndrome at National Institute of Kidney Diseases and Urology, Dhaka, Bangladesh an experience of one decade

Alam

Hossain²,

Khan³

et al. 2017

Northern Int. Med. Coll. J.

View full text Add to dashboard Cite

Background : Nephrotic syndrome (NS) is one of the most common renal diseases in children. The cause of idiopathic nephrotic syndrome is still unknown. Once the prevalence of minimal change nephritic syndrome occupied the three forth portion of the total renal pathology and most of them were steroid sensitive. But list of steroid insensitive nephritic syndrome become more longer today. Therefore renal biopsy is essential for histopathological diagnosis which guides the most accurate way for the treatment of such diseases.

show abstract

Childhood steroid-sensitive nephrotic syndrome: Does the histology matter?

Cited by 32 publications

References 11 publications

Effect of Intrauterine Growth Retardation on the Progression of Nephrotic Syndrome

Effect of Intrauterine Growth Retardation on the Progression of Nephrotic Syndrome

The long-term outlook to final outcome and steroid treatment results in children with idiopathic nephrotic syndrome

Renal Histopathology in Childhood Nephrotic Syndrome at National Institute of Kidney Diseases and Urology, Dhaka, Bangladesh an experience of one decade

Contact Info

Product

Resources

About

Childhood steroid-sensitive nephrotic syndrome: Does the histology matter?

Cited by 32 publications

References 11 publications

Effect of Intrauterine Growth Retardation on the Progression of Nephrotic Syndrome

Effect of Intrauterine Growth Retardation on the Progression of Nephrotic Syndrome

The long-term outlook to final outcome and steroid treatment results in children with idiopathic nephrotic syndrome

Renal Histopathology in Childhood Nephrotic Syndrome at National Institute of Kidney Diseases and Urology, Dhaka, Bangladesh an experience of one decade

Contact Info

Product

Resources

About

Renal Histopathology in Childhood Nephrotic Syndrome at National Institute of Kidney Diseases and Urology, Dhaka, Bangladesh an experience of one decade