Childhood Socioeconomic Status and Depressive Symptoms of Young Adults: Mediating Role of Childhood Trauma

Yang, Cheng-Ao; Chen, Peiyi; Xie, Jian‐Hua; He, Yongtong; Wang, You; Yang, Xueling

doi:10.3389/fpsyt.2021.706559

Cited by 8 publications

(9 citation statements)

References 49 publications

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“…The role of environmental factors in the pathogenesis of MDD has attracted greater attention from physicians and researchers ( Foster et al, 2017 ; O’Mahony et al, 2017 ). Several studies have shown that people who have experience of physical abuse (PA) or emotional abuse (EA) are more likely to suffer from depression ( Biedermann et al, 2021 ; Husain et al, 2021 ), and the severity of symptom is strongly associated with childhood maltreatment ( Whitaker et al, 2021 ; Yang et al, 2021 ; Rep et al, 2022 ). According to a study, the effects of childhood maltreatment could last for decades and are strongly associated with the onset of mental disorders at an older age ( Macpherson et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Mediating Effect of Gut Microbiota With Experience of Childhood Maltreatment in Major Depressive Disorder

Zhang

Liu

et al. 2022

Front. Neurosci.

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Gut microbiota and childhood maltreatment are closely related to depressive symptoms. This study aimed to analyze the characteristics of gut microbiota in major depressive disorder (MDD) patients with childhood maltreatment experience and explore the correlation between gut microbiota, childhood maltreatment, and depressive symptoms. A total of 37 healthy controls (HCs) and 53 patients with MDD were enrolled, including 18 MDD patients without childhood maltreatment experience and 35 MDD patients with childhood maltreatment experience. The Hamilton’s Depression Scale (HAMD-24) and Childhood Trauma Questionnaire-Short Form (CTQ-SF) were used to evaluate their depressive symptoms and childhood maltreatment experience, respectively. The composition of gut microbiota was evaluated using 16S rRNA sequencing. Spearman’s correlation analysis was used to evaluate the correlation between different gut microbiota, depressive symptoms and childhood maltreatment. The mediation analysis was used to evaluate the mediating effect of gut microbiota. In the α-diversity analysis, we found that the Simpson index and Pielou’s Evenness index differed significantly between MDD patients without childhood maltreatment experience and HCs. In the β-diversity analysis, principal coordinate analysis (PCoA) showed significant differences between MDD patients without childhood maltreatment experience, MDD patients with childhood maltreatment experience and HCs. Twenty-seven different bacteria were identified through Linear discriminant analysis effect size (LEfSe) analysis at different levels of classification. The analysis of the correlation showed that Blautia, Bifidobacterium, Bacteroides, Roseburia, and Phascolarctobacterium were significantly correlated with HAMD and CTQ-SF scores. The mediation analysis showed that childhood maltreatment had a significant direct effect on the patients’ depressive symptoms, and Blautia, Bifidobacterium, Roseburia had a significant mediating effect. The findings of this study suggested that MDD patients with childhood maltreatment experience had different gut microbiota, which might have a mediating effect on the influence of childhood maltreatment on depressive symptoms.

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Section: Introductionmentioning

confidence: 99%

Characteristics and Mediating Effect of Gut Microbiota With Experience of Childhood Maltreatment in Major Depressive Disorder

Zhang

Liu

et al. 2022

Front. Neurosci.

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“…Based on theoretical deliberations implying an influence of maternal age (e.g., [ 67 , 68 ]), parity (e.g., [ 69 ]), academic degree (e.g., [ 70 , 71 ]), FOC, and depressive symptoms (e.g., [ 4 , 31 ]) on lifetime trauma, stress-related hair biomarkers, and CB-PTSS, these were controlled for as confounding variables [ 72 ]. Exposure to the COVID-19 pandemic did not affect CB-PTSS ( r s = −.02, p = .701), and was therefore not included in analyses with CB-PTSS as the dependent variable.…”

Section: Methodsmentioning

confidence: 99%

Childbirth-related posttraumatic stress symptoms – examining associations with hair endocannabinoid concentrations during pregnancy and lifetime trauma

Bergunde,

Karl,

Schälicke

et al. 2023

Transl Psychiatry

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Evidence has linked alterations of the endocannabinoid system with trauma exposure and posttraumatic stress disorder (PTSD). Childbirth-related PTSD symptoms (CB-PTSS) affect about every eighth woman and can negatively influence the entire family. While aetiological models of CB-PTSD include psychological risk factors such as maternal trauma history and negative subjective birth experience (SBE), they lack biological risk indicators. We investigated whether lifetime trauma and CB-PTSS were associated with long-term endocannabinoid concentrations during pregnancy. Further, we tested endocannabinoids as mediators between lifetime trauma and CB-PTSS and whether SBE moderated such mediational paths. Within the prospective cohort study DREAMHAIR, 263 expectant mothers completed trauma assessments and provided hair samples for quantification of long-term endocannabinoid levels (anandamide [AEA], 2-arachidonoylglycerol [1-AG/2-AG], and N-acyl-ethanolamides [NAE]) prior to their anticipated birth date. Two months postpartum, CB-PTSS and SBE were measured. Regression models controlling for relevant confounders showed no association between lifetime trauma and hair endocannabinoids during pregnancy, yet higher number of lifetime trauma events and lower hair AEA were significantly associated with CB-PTSS, with the latter finding not remaining significant when Bonferroni corrections due to multiple testing were applied. While hair AEA did not mediate the association between lifetime trauma and CB-PTSS, the effect of lower hair AEA on CB-PTSS was stronger upon negative SBE. Results suggest greater lifetime trauma and reduced maternal hair AEA during pregnancy may be associated with increased risk for CB-PTSS, particularly upon negative SBE. Findings confirm lifetime trauma as a CB-PTSS risk factor and add important preliminary insights on the role of endocannabinoid ligand alterations and SBE in CB-PTSS pathology.

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“…Social determinants of health are described as "conditions in the places where people live, learn, work, and play, that impact many health risks and outcomes" (1). The causal priority is ascribed to the environmental factors of childhood in considering the social gradient in mental health, a concept known as the "indirect selection of health services" hypothesis (2,3).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Life Satisfaction and Subjective Social Mobility Status Among Women of Rasht City: A Cross-Sectional Analytical Study

Namazi,

Rafiey,

Mousavi

et al. 2024

Jundishapur J Health Sci

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Background: The social causation hypothesis suggests that health is influenced by various social factors, including childhood living conditions and mobility pathways, and individual life satisfaction is primarily derived from the subjective sense of mobility and social class. Objectives: Adverse changes in social factors and their negative effects on health have been observed in numerous studies. This study aimed to investigate the relationship between life satisfaction and subjective social mobility status in women from Rasht. Methods: Conducted between 2020 and 2021, this cross-sectional correlational study examined 800 married women residing in Rasht who met the inclusion criteria. Participants were selected using a cluster random method from various areas of the city. Data collection tools included demographic characteristics, the Ferrans and Powers Quality-of-Life Questionnaire, and the MacArthur Scale to measure participants' socioeconomic status (SES). Data analysis was performed using SPSS software and parametric statistical tests. Results: The samples generally comprised individuals with intermediate socioeconomic status, and most participants indicated that their current living situation was better than that of their parents. The lowest average life satisfaction score was observed in the low socioeconomic status group, with participants experiencing downward mobility reporting the lowest life satisfaction scores. However, the results showed no significant difference in the satisfaction levels among different social mobility groups of women (P = 0.60). Conclusions: Our findings underscore the importance of researchers reflecting on and being sensitive to experiences related to social class and mobility. The study confirmed that individuals with downward social mobility tend to have lower life satisfaction. Social factors are strongly associated with health outcomes, emphasizing the need for the modern healthcare system to consider the impact of social factors on individuals' well-being.

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Childhood Socioeconomic Status and Depressive Symptoms of Young Adults: Mediating Role of Childhood Trauma

Cited by 8 publications

References 49 publications

Characteristics and Mediating Effect of Gut Microbiota With Experience of Childhood Maltreatment in Major Depressive Disorder

Characteristics and Mediating Effect of Gut Microbiota With Experience of Childhood Maltreatment in Major Depressive Disorder

Childbirth-related posttraumatic stress symptoms – examining associations with hair endocannabinoid concentrations during pregnancy and lifetime trauma

The Association Between Life Satisfaction and Subjective Social Mobility Status Among Women of Rasht City: A Cross-Sectional Analytical Study

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