Childhood Socioeconomic Circumstances, Inflammation, and Hemostasis Among Midlife Women

Matthews, Karen A.; Chang, Yue‐Fang; Bromberger, Joyce T.; Karvonen‐Gutierrez, Carrie; Kravitz, Howard M.; Thurston, Rebecca C.; Montez, Jennifer Karas

doi:10.1097/psy.0000000000000283

Cited by 16 publications

(8 citation statements)

References 33 publications

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“…In the 1958 cohort, associations for neglect, physical abuse and childhood socioeconomic disadvantage with adult inflammation, were evident also with adult adiposity, likewise in MIDUS, for sexual abuse. Thus, like others 13,23 , our results suggest that adult adiposity may be intermediate between childhood socioeconomic disadvantage and CRP.…”

Section: Discussionsupporting

confidence: 86%

“…First, associations may have been missed because many previous studies are based on small samples with low prevalence of child maltreatment. Second, while the literature is more extensive on links between early adversities and adiposity 18,19 and between adiposity (including adiposity gain) and inflammatory markers [20][21][22] , few studies 9,23,24 examine whether early adversities are related to adult inflammation via their link with adiposity (or adiposity gain) over periods of the life-course. Such knowledge gaps are important because Mendelian randomisation studies suggest that adiposity causally influences inflammation 20,21 .…”

Section: Introductionmentioning

confidence: 99%

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Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA

Pereira

Merkin

Seeman

et al. 2019

Brain, Behavior, and Immunity

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Objectives: In two cohorts, we aimed to establish associations between early-life adversities and adult inflammation, and whether adult (a) adiposity or (b) socioeconomic disadvantage are key intermediaries. Methods: In both cohorts (N=7,661, 1958 British birth cohort; N=1,255, MIDUS), information was used on adult inflammatory markers (C-reactive protein (CRP), fibrinogen and (MIDUS only) interleukin-6 (IL-6)), adiposity and socioeconomic disadvantage, and early-life adversities (neglect, emotional neglect, physical, psychological, sexual abuse and childhood disadvantage). Results: Early-life adversities varied from 1.6% (sexual abuse, 1958 cohort) to 14.3% (socioeconomic disadvantage, MIDUS). Across the two cohorts, associations were consistent for physical abuse, e.g. 16.3%(3.01,29.7) and 17.0%(-16.4,50.3) higher CRP in the 1958 cohort and MIDUS respectively. Associations attenuated after accounting for adult adiposity, e.g. physical abuse (1958 cohort) and sexual abuse (MIDUS, non-white participants) associations abolished. Some associations attenuated after adjustment for adult socioeconomic disadvantage; e.g. 1958 cohort neglect−CRP associations reduced from 23.2%(13.7,32.6) to 17.7%(8.18,27.2). Across the cohorts, no associations were found for psychological abuse or emotional neglect; associations for childhood socioeconomic disadvantage were inconsistent. Conclusions: Specific early-life adversities are associated with adult inflammation; adiposity is a likely intermediary factor. Weight reduction and obesity prevention may offset pro-inflammatory related adult disease among those who experienced early-life adversities. Aims of the Study Using data from two cohorts, from the UK and USA, we addressed several of these outstanding questions. Specifically, we investigated associations between early-life adversities, adult inflammatory markers, adiposity and adult socioeconomic disadvantage. Inclusion of two populations provides an opportunity, to the extent that study design allows, to standardise research aims and analytic approach and to assess replicability of findings across populations. Specific aims, were to establish (i) whether early-life adversities are associated with markers of inflammation (CRP, fibrinogen, IL-6) in adulthood and whether associations vary by type of early-life adversity; and (ii) whether associations are consistent with the hypotheses that (a) adiposity (or adiposity trajectory) or (b) adult socioeconomic disadvantage are key intermediaries between early-life adversities and pro-inflammation states. Methods Study samples 1958 British birth cohort is an ongoing longitudinal study of all born in one week in March 1958 across England, Scotland and Wales (n=17,638) with a further 920 immigrants with the same birth week recruited up to age 16y 27. Information was collected at several ages throughout child and adulthood. At 45y, 9,377 (78% of 11,971 invited) individuals participated in a biomedical survey; respondents were broadly representative of the total surviving cohort 28. Ethica...

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA

Pereira

Merkin

Seeman

et al. 2019

Brain, Behavior, and Immunity

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“…Class 2 contains women with low educated but non-poor parents (50% of women). Class 3 is the highest SES, with highly educated and non-poor parents (24% of women) (15). These latent classes have been successfully used in previous SWAN studies to examine their association with inflammation and metabolic syndrome (15;16).…”

Section: Methodsmentioning

confidence: 99%

Childhood socioeconomic circumstances and depressive symptom burden across 15 years of follow-up during midlife: Study of Women’s Health Across the Nation (SWAN)

Bromberger

Schott

Matthews

et al. 2017

Arch Womens Ment Health

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Purpose Childhood socioeconomic disadvantage may contribute to adult depression. Understanding pathways by which early socioeconomic adversity may shape adult depression is important for identifying areas for intervention. Studies to date have focused on one potential pathway, adult socioeconomic status (SES), and assessed depression at only one or a few time points. Our aims were to examine (a) the association between childhood SES (low vs high) and depressive symptom burden in midlife and (b) whether adult socioeconomic, psychosocial, and physical health characteristics are important pathways. Methods Using annual data from a cohort of 1109 black and white U.S. women recruited in 1996–97, we evaluated the association between childhood SES and depressive symptom burden across 15 years in midlife and whether adult characteristics—financial difficulty, lower education, stressful events, low social support, low role functioning, medical conditions, and bodily pain—mediated the association. Depressive symptom burden was estimated by calculating area under the curve of annual scores across 15 years of the Center for Epidemiological Studies-Depression (CES-D). Results In unadjusted models, low childhood SES was associated with greater depressive burden (P=0.0002). Each hypothesized mediator, individually, did not reduce the association. However, when 5 of the hypothesized mediators were included together in the same analysis, they explained more than two thirds of the association between childhood SES and depressive symptom burden reducing the P-value for childhood SES to non-significance (P=0.20). Conclusions These results suggest that childhood SES influences midlife depression burden through a cluster of economic stress, limited social resources and physical symptoms in adulthood.

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“…These effects were robust to several potential demographic and clinical confounds (e.g., ethnicity, study site, age, health problems, smoking status, medication use, etc. ), and they appeared to be mediated by individuals' body mass index (BMI) and education level in adulthood (Matthews et al, 2016).…”

Section: Early Adversity and Inflammationmentioning

confidence: 99%

Psychoneuroimmunology of Stress and Mental Health

Slavich

2019

The Oxford Handbook of Stress and Mental Health

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Psychoneuroimmunology (PNI) is the study of how psychological, neural, and immunologic processes interact and affect human health and behavior. Although once a relatively small field, some of the most exciting discoveries in psychopathology and mental health research have recently involved ideas and methods from PNI. In reviewing this work, I first summarize the structure and function of the human immune system, focusing primarily on inflammation. Second, I describe neural and physiologic pathways that link the brain and immune system, which give neurocognitive processes the ability to regulate the immune system and immunologic processes the ability to affect neural, cognitive-emotional, and behavioral outcomes. Third, I review studies examining associations between life stress and inflammation, and inflammation and mental health. Finally, I highlight several promising avenues for future research. Overall, despite the notable impact that PNI has already had on our understanding of mental and physical health, many important questions remain unanswered.

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Childhood Socioeconomic Circumstances, Inflammation, and Hemostasis Among Midlife Women

Cited by 16 publications

References 33 publications

Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA

Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA

Childhood socioeconomic circumstances and depressive symptom burden across 15 years of follow-up during midlife: Study of Women’s Health Across the Nation (SWAN)

Psychoneuroimmunology of Stress and Mental Health

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