Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women

Kendler, Kenneth S.; Bulik, Cynthia M.; Silberg, Judy L.; Hettema, John M.; Myers, John; Prescott, Carol A.

doi:10.1001/archpsyc.57.10.953

Cited by 1,133 publications

(890 citation statements)

References 41 publications

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“…It has been estimated that approximately 30-40% of the risk of depression across the life course is genetically determined, while the rest of the risk can be attributed to environmental factors (Merkangas and Swendsen, 1997;Heim and Binder, 2012). The role of early life environmental stress factors in developing major depression, apart from genetic factors, has been demonstrated in twin studies (Kendler et al, 2000). Such childhood stressors include physical, sexual, emotional and verbal abuse, neglect, social deprivation, household dysfunctions including violence and witnessing violence, poverty, parental separation, parental death or illness, disaster, substance abuse and criminal activity (Brown et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses

Lindström

Fridh

2014

Psychiatry Research

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Link to publication Citation for published version (APA): Lindström, M., Fridh, M., & Rosvall, M. (2014). Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses. Psychiatry Research, 215(2), 386-393. DOI: 10.1016/j.psychres.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Logistic regression models were used to investigate the associations adjusting for age, country of birth, socioeconomic status, emotional support, instrumental support and trust, and stratifying by sex. The accumulation hypothesis was confirmed because combined childhood and adulthood exposures to economic stress were associated with poor psychological health in a graded manner. The social mobility hypothesis was also confirmed. The critical period hypothesis was not confirmed because both childhood and adulthood economic stress remained significantly associated with poor psychological health in adulthood. Economic stress in childhood is associated with mental health in adulthood.

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Section: Introductionmentioning

confidence: 99%

Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses

Lindström

Fridh

2014

Psychiatry Research

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“…In particular, several clinical and population studies, both retrospective and prospective, suggest that CM plays a role as a predisposing factor for the later onset of different psychiatric symptoms and disorders, such as major depression, post-traumatic stress disorder, drug abuse, anxiety symptoms, dissociation, body dysmorphic and eating disorders, psychotic experiences and personality disorder. 5,[12][13][14][15][16][17][18][19][20][21] Moreover, several studies have focused on the negative impact of CM on body image, both in a nonclinical sample and in subjects with eating disorders. 17,18,22 It is often difficult to ascertain the meaningful link between CM and adult psychopathology.…”

Section: Introductionmentioning

confidence: 99%

Childhood maltreatment in subjects with male-to-female gender identity disorder

et al. 2011

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“…Women exposed to CSA have an increased risk for different psychopathologies in adulthood including addictions to alcohol and other drugs; [2][3][4][5][6] antisocial personality disorder (ASPD); 4,5 major depression, 7-9 suicidal behavior; 4,8,10,11 post-traumatic stress disorder 4,12,13 and eating disorders. 6 The impact of CSA on adult mental health is only one of the complex set of intercorrelated social, economic and familial disadvantages and as such the presence of CSA is an indicator of a wider and larger dysfunction within families. 1,5 In addition, within particular socio-cultural contexts, such as occurs in certain American Indian tribes, rates of violence and cumulative trauma are very high, potentially amplifying within-family effects and contributing to the high vulnerability to psychiatric disorders found overall in these communities.…”

Section: Introductionmentioning

confidence: 99%

Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women

et al. 2007

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Women who have experienced childhood sexual abuse (CSA) have an increased risk of alcoholism and antisocial personality disorder (ASPD). Among male subjects, a functional polymorphism (MAOA-LPR, monoamine oxidase A linked polymorphic region) in the promoter region of the monoamine oxidase A gene (MAOA) appears to moderate the effect of childhood maltreatment on antisocial behavior. Our aim was to test whether MAOA-LPR influences the impact of CSA on alcoholism and ASPD in a sample of 291 women, 50% of whom have experienced CSA; we also tested whether haplotypes covering the region where both MAOA and monoamine oxidase B (MAOB) genes are located predict risk of alcoholism and ASPD better than the MAOA-LPR locus alone. Participants included 168 alcoholics (39 with ASPD (antisocial alcoholics) and 123 controls (no alcoholics, no ASPD). Antisocial behavior was also modeled as a continuous trait: ASPD symptoms count. The MAOA-LPR low activity allele was associated with alcoholism (P = 0.005), particularly antisocial alcoholism (P = 0.00009), only among sexually abused subjects. Sexually abused women who were homozygous for the low activity allele had higher rates of alcoholism and ASPD, and more ASPD symptoms, than abused women homozygous for the high activity allele. Heterozygous women displayed an intermediate risk pattern. In contrast, there was no relationship between alcoholism/antisocial behavior and MAOA-LPR genotype among non-abused women. The MAOA-LPR low activity allele was found on three different haplotypes. The most abundant MAOA haplotype containing the MAOA-LPR low activity allele was found in excess among alcoholics (P = 0.008) and antisocial alcoholics (P = 0.001). Finally, a MAOB haplotype, which we termed haplotype C, was significantly associated with alcoholism (P = 0.006), and to a lesser extent with antisocial alcoholism (P = 0.03). In conclusions, MAOA seems to moderate the impact of childhood trauma on adult psychopathology in female subjects in the same way as previously shown among male subjects. The MAOA-LPR low activity allele appears to confer increased vulnerability to the adverse psychosocial consequences of CSA. Haplotype-based analysis of the MAOA gene appeared to strengthen the association, as compared to the MAOA-LPR locus alone. A MAOB haplotype was associated with alcoholism independently from ASPD.

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Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women

Cited by 1,133 publications

References 41 publications

Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses

Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses

Childhood maltreatment in subjects with male-to-female gender identity disorder

Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women

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