Childhood Primary Angiitis of the Central Nervous System With Metachronous Hemorrhagic Infarcts: A Postmortem Study With Clinicopathologic Correlation

Katsetos, Christos D.; Poletto, Erica; Kasmire, Kathryn E.; Walleigh, Diana J.; Kumar, Indira; Pascasio, Judy Mae; Legido, Agustín; Goldsmith, Donald P.

doi:10.1016/j.spen.2014.06.001

Cited by 5 publications

(3 citation statements)

References 21 publications

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“… 1 , 5 The histopathology of this patient suggested lymphocytic vasculitis, which was consistent with previously reported cases in children. 2 , 7 More research are needed to identify the histopathological features of tumor‐like PACNS in children.…”

Section: Discussionmentioning

confidence: 99%

“…Digital subtraction angiography and brain biopsy are often necessary because the clinical presentation and cranial imaging findings are non‐specific. To date, only a few cases of tumor‐like PACNS in children have been reported 2–4 . We describe in detail a case of tumor‐like PACNS confirmed by brain biopsy to remind pediatricians of the possibility of this disease when dealing with intracranial tumor‐like lesions.…”

Section: Introductionmentioning

confidence: 90%

“…To date, only a few cases of tumorlike PACNS in children have been reported. [2][3][4] We describe in detail a case of tumor-like PACNS confirmed by brain biopsy to remind pediatricians of the possibility of this disease when dealing with intracranial tumor-like lesions. Early diagnosis and prompt immunotherapy can improve the prognosis and avoid surgery.…”

Section: Introductionmentioning

confidence: 99%

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A 5‐year‐old child presenting with tumor‐like primary angiitis of the central nervous system

Zhuo

Feng

Zhou

et al. 2022

Pediatric Investigation

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Introduction:Primary angiitis of the central nervous system (PACNS) is a vasculitis confined to the CNS. A small proportion of the lesions may present as a tumor-like mass, which is rarely seen in children. Case presentation: A 5-year-old girl was admitted to our hospital because of an intermittent headache. Brain imaging suggested a space-occupying lesion in the right cerebral hemisphere. The final diagnosis was PACNS with a lymphocytic pattern by stereotactic brain biopsy. Her condition improved after immunotherapy. Conclusion: Pediatricians should consider the possibility of PACNS when encountering intracranial tumor-like lesions. Early diagnosis of tumor-like PACNS and prompt immunotherapy could improve the long-term prognosis and avoid surgery.

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