Childhood onset schizophrenia: familial neurocognitive measures

Gochman, Peter; Greenstein, Deanna; Sporn, Alexandra; Gogtay, Nitin; Nicolson, Rob; Keller, A.; Lenane, Marge; Brookner, Francis; Rapoport, Judith L.

doi:10.1016/j.schres.2004.01.012

Cited by 33 publications

(19 citation statements)

References 22 publications

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“…However, the current study is not unique in this regard since negative results of such comparisons have also been reported for executive functions [24,25] and other cognitive tests, e.g. the DST and Vocabulary [52]. …”

Section: Discussionmentioning

confidence: 89%

Cognitive Impairment and Formal Thought Disorders in Parents of Early-Onset Schizophrenia Patients

Remberk

Namysłowska²,

Rybakowski³

2012

Neuropsychobiology

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Background: Both cognitive impairment and formal thought disorder (communication disturbances) found in patients with schizophrenia are also commonly observed in their relatives. Recently, the role of such deficits as putative endophenotypes of schizophrenia has been proposed. However, in a majority of studies, the families of adult patients were assessed whereas the relatives of early-onset psychotic subjects were rarely studied. The aim of our study was to evaluate the presence of cognitive impairment and formal thought disorders in parents of adolescents with a diagnosis of schizophrenia spectrum disorder (SSD) and in matched healthy controls. Method: Thirty-eight parents of 29 SSD adolescents and 38 healthy controls were assessed with a battery of neurocognitive tests and the Thought, Language and Communication Scale. Results: Parents of schizophrenia patients showed an increased tendency for perseverative thinking when compared to matched healthy controls. No statistically significant differences in cognitive functioning were observed between the groups. Conclusion: These results may suggest the need for further exploration of communication disturbances as a potential endophenotypic marker of early-onset schizophrenia.

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Section: Discussionmentioning

confidence: 89%

Cognitive Impairment and Formal Thought Disorders in Parents of Early-Onset Schizophrenia Patients

Remberk

Namysłowska²,

Rybakowski³

2012

Neuropsychobiology

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“…15 . Non-psychotic first degree relatives of patients with COS showed impairments on a measure of attention/executive function 16 and in smooth pursuit eye tracking, 17 and non-psychotic siblings of COS probands showed deficits on a procedural skill learning task supported by a cortical-striatal network. 18 A longitudinal study 19 found that prior to adolescence the non-psychotic siblings of patients with COS show reduced cortical gray matter in the superior temporal prefrontal areas, but that this reduction normalizes during adolescence.…”

Section: Familial Aggregation Studiesmentioning

confidence: 93%

Genetics of Childhood-onset Schizophrenia

Asarnow

Forsyth

2013

Child and Adolescent Psychiatric Clinics of North America

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Synopsis Schizophrenia is a highly heritable disorder. The genetic architecture of schizophrenia is complex and heterogeneous involving both common and rare allelic variants. Given the low prevalence of childhood-onset schizophrenia (COS), relatively few studies have examined the genetic architecture of COS. This review discusses genetic studies of COS and compares findings in familial aggregation, common allele and rare allele studies of COS to those for adult onset schizophrenia (AOS). Overall, the extant literature suggests that COS is a rare variant of AOS with greater familial aggregation of schizophrenia spectrum disorders and a higher occurrence of rare allelic variants. Given the complex genetic architecture of schizophrenia, the utility of genetic screening for diagnosis and individualized treatment is currently limited; however, identifying common pathways through which multiple genes adversely impact neural systems offers great promise towards developing novel pharmacologic interventions.

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“…It is unclear whether these deficits represent an underlying global cognitive deficit or whether each one represents a discrete endophenotype transmitted in families of schizophrenic patients [62]. When we compared neuropsychological deficits in 67 parents and 24 full siblings of COS probands with matched community controls for Trail Making Tests A and B, Wechsler Intelligence Scale-Revised Digit Span and Vocabulary, COS siblings performed significantly poorer than community controls although the rates of neuropsychological abnormalities for COS were not significantly higher than for AOS [63].…”

Section: Familial Schizophrenia Spectrum Disordersmentioning

confidence: 96%

Phenomenology and Neurobiology of Childhood Onset Schizophrenia

Gogtay¹

2006

CPSR

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Childhood-onset schizophrenia (COS; defined as onset by age 12) is rare, difficult to diagnose, and represents a severe and chronic phenotype of the adult illness. A study of childhood onset psychoses has been ongoing at the NIMH since 1990, where children with childhood onset schizophrenia (COS) and severe atypical psychoses (provisionally labeled "multidimensionally impaired" or MDI by the NIMH team) are studied. Familial risk factors, genetic analyses, neurocognitive functioning, and brain imaging data are obtained every two years on probands and all first degree relatives. Multiple analysis from the NIMH study have found that COS subjects have more severe premorbid neurodevelopmental abnormalities, a higher rate of genetic anomalies, and a robust cortical gray matter (GM) loss during adolescence, which proceeds in a 'back to front wave like fashion' and appears to be an exaggeration of the normal cortical gray matter developmental pattern. These cortical GM changes in COS are diagnostically specific and seemingly unrelated to the effects of medications, as they are not shared by medication matched MDI patients, or psychosis not otherwise specified (NOS) patients who have converted to bipolar I at follow up.

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Childhood onset schizophrenia: familial neurocognitive measures

Cited by 33 publications

References 22 publications

Cognitive Impairment and Formal Thought Disorders in Parents of Early-Onset Schizophrenia Patients

Cognitive Impairment and Formal Thought Disorders in Parents of Early-Onset Schizophrenia Patients

Genetics of Childhood-onset Schizophrenia

Phenomenology and Neurobiology of Childhood Onset Schizophrenia

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