Childhood-Onset Myasthenia Gravis With Thymoma

Nikolić, Dimitrije; Nikolić, Aleksandra; Lavrnić, Dragana; Medjo, Biljana; Ivanovski, Petar

doi:10.1016/j.pediatrneurol.2012.02.025

Cited by 18 publications

(10 citation statements)

References 13 publications

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“…As reported in the literature [2,8], most of our patients were symptomatic. Chemotherapy was mainly administrated as [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. This study pointed out the lack of guidelines for the management of this rare tumor, especially for surgery, and led us to explore the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The search terms included "thymoma," "pediatric," "children," "childhood" and/or "thymic carcinoma." Exclusion criteria were cases with no description of the histopathologic subtype (WHO classification) and/or without details on follow-up [2,8,[14][15][16][17][18][19][20]. R0 resection corresponds to complete tumor resection with histologically free margins, R1 corresponds to macroscopic resection, but invaded margins on histology, R2 corresponds to macroscopic residual tumor, or biopsy alone with no surgical resection.…”

Section: Methodsmentioning

confidence: 99%

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Surgical management of thymic epithelial tumors in children: Lessons from the French Society of pediatric oncology and review of the literature

Rod

Orbach

Vérité

et al. 2014

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Surgical management of thymic epithelial tumors in children: Lessons from the French Society of pediatric oncology and review of the literature

Rod

Orbach

Vérité

et al. 2014

Pediatric Blood & Cancer

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“…98 Thymectomy remains controversial, as rates of thymoma in children are quite low. 99 Thymectomy does not appear to reduce risk for ocular myasthenia to generalized myasthenia. 100 The long-term immune system implications of thymectomy in younger children are unclear.…”

Section: Autoimmune Neuromuscular Junction Disorders Juvenile Myasthementioning

confidence: 98%

Autoimmune Neurologic Diseases in Children

Sweeney

2018

Semin Neurol

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Autoimmune diseases of the nervous system in children are composed of a heterogeneous group of rare disorders that can affect the central or peripheral nervous system at any level. Presentations may occur in children of any age and are typically acute or subacute in onset. Consideration of an autoimmune process as the etiology of neurologic diseases in children is important, as it may lead to early initiation of immunotherapy and an improvement in long-term neurologic outcomes. The developing nervous and immune systems in children create unique challenges in diagnosis and treatment of these rare diseases. In this review, autoimmune diseases affecting the brain, spinal cord, nerve roots, peripheral nerves, neuromuscular junction, and muscle in children are described.

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“…Myasthenia gravis and other paraneoplastic syndromes are rarely associated with thymoma in children. Only ten cases of myasthenia gravis have been reported in the pédiatrie literature (7).…”

Section: Discussionmentioning

confidence: 99%

On İki Yaşında Bir Kızda B3 Tipi Timoma

Duru¹,

Çivilibal²,

Elevli³

2013

haseki

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Thymic epithelial tumors consist of thymomas, thymic carcinoids, and thymic carcinomas. Most cases occur over the age of 20 years, and 70%of cases in patients over 40 years of age. Thymomas are extremely uncommon in children, accounting for less than 1%of childhood mediastinal tumours compared with 30%in adults and, because of their rarity may be difficult to diagnose. In this paper, we present a 12-year-old girl who presented with symptoms of pneumonia such as cough, fever and chest pain. Her chest x-ray showed expansion of the mediastinum and opacity in the right hemithorax. An anterior mediastinal mass was determined by chest computed tomography. Histological and immunochemicai examination of the surgically excised mass showed type B3 thymoma. The case is presented for its rarity in children. (Haseki Tip Bülteni 2013; 51: 200-02) Ozet Timik epitelyal tümörler; timomalar, timik karsinoidler ve timik karsinomalan kapsamaktadir. Hemen hemen tamami 20 yaj üstü olan olgulann %70'i 40 yaj üstüdür. Mediastinal tümörler içinde eriçkinlerdeki %30'luk oran ile karjilajtinldiginda çocuklarda %1 oranindaki görülme sikligi tani koymayi güciejtirir. Biz burada öksürük, atej ve gögüs agnsi gibi pnömoni bulgulan ile gelen 12 yasinda bir kiz çocugunu sunduk. Akciger grafisinde mediastinal genijieme ve sagda opasite görülen hastanin bilgisayarli tomografisinde kitle saptandi. Cerrahi olarak çikanlan kitlenin histolojik ve immünohistokimyasal incelemeleri B3 timoma oldugunu gösterdi. Olgu çocuklarda timomanin nadir görülmesi nedeni ile sunulmujtur. (The Medical Bulletin of Haseki 2013; 51: 200-02) Anahtar Kelimeler: Çocukluk çagi, mediastinal kitle, timoma

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Childhood-Onset Myasthenia Gravis With Thymoma

Cited by 18 publications

References 13 publications

Surgical management of thymic epithelial tumors in children: Lessons from the French Society of pediatric oncology and review of the literature

Surgical management of thymic epithelial tumors in children: Lessons from the French Society of pediatric oncology and review of the literature

Autoimmune Neurologic Diseases in Children

On İki Yaşında Bir Kızda B3 Tipi Timoma

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