Childhood Obsessive–Compulsive Disorder: A Prospective Follow‐up Study

Flament, Martine F.; Koby, Elisabeth V.; Rapoport, Judith L.; Berg, Chantal van den; Zahn, Theodore P.; Cox, Christine L.; Denckla, Martha B.; Lenane, Marge

doi:10.1111/j.1469-7610.1990.tb01575.x

“…The onset of the disease can even occur during childhood. 4 Pauls et al observed a higher familial loading of OCD in early onset cases, thus suggesting that genetic factors might be of greater importance in early onset OCD. 3 Serotonin (5-HT) dysfunction has been implicated in OCD and is thought to contribute to behavioural traits such as perfectionism and obsessiveness and is described as associated with anxiety and depression 5,6 and vice versa.…”

mentioning

confidence: 99%

5-HT2A promoter polymorphism −1438G/A in children and adolescents with obsessive-compulsive disorders

Walitza

¹

,

Wewetzer

²

,

Warnke

³

et al. 2002

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Keywords: obsessive-compulsive disorder; 5HT 2A polymorphism; association study; child and adolescent psychiatry Positive association between obsessive compulsive disorder (OCD) and the A-allele of the 5-HT 2A -receptor promoter polymorphism −1438G/A has recently been reported in adults. We performed an association analysis of this polymorphism in 55 children and adolescents with OCD and in 223 controls consisting of unrelated students. We detected statistically significant differences in genotype (P < 0.05) and allele frequencies (P < 0.05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD.

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“…O diagnóstico atual de ST é dado quando o paciente apresenta múltiplos tiques motores e pelo menos um tique vocal (não sendo necessário que os tiques motores e vocais ocorram concomitantemente) por um período mínimo de 1 ano, no qual os tiques não tenham estado ausentes por mais de 3 meses consecutivos (Tabela 2). 20,21 . Idéias ruminativas de conteúdo depressivo podem ser confundidas com pensamentos obsessivos, sendo que a presença de comportamentos repetitivos é um dos fatores que pode auxiliar na distinção dos dois transtornos.…”

Section: Critérios Diagnósticosunclassified

The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome

Mercadante¹,

Rosario²,

Sato³

2004

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Objective: To describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and Tourette syndrome. Sources of data:A review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed.Summary of the findings: Ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. The definitions of obsessive-compulsive disorder and Tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. Neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders. ResumoObjetivo: Revisar as teorias e evidências das bases neurobiológi-cas do transtorno obsessivo-compulsivo e da síndrome de Tourette. Fontes dos dados:Revisão dos estudos que investigam a neuroanatomia, neuroimagem, genética e imunologia desses transtornos. Síntese dos dados:Os comportamentos ritualísticos e pensamentos repetitivos têm sido cada vez mais estudados em nosso meio. As definições dessas entidades formam um continuum espectral de sintomas com prevalência significativa na população.Conclusões: Os avanços das neurociências possibilitaram a exploração dos aspectos genéticos do sistema nervoso central e seu funcionamento, fornecendo novas perspectivas para o tratamento de pacientes com transtorno obsessivo-compulsivo e síndrome de Tourette. As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette

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“…20,21 Depressive ruminations may be mistaken for obsessive thoughts, but the presence of repetitive behaviors may help distinguish between the two disorders.…”

Section: Differential Diagnosismentioning

confidence: 99%

As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette

Mercadante¹,

Rosario-Campos²,

Sato³

2004

J. Pediatr. (Rio J.)

3

0

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Objective: To describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and Tourette syndrome. Sources of data:A review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed.Summary of the findings: Ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. The definitions of obsessive-compulsive disorder and Tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. Neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders.Conclusions: Advances in neuroscience triggered genetic and immunological research studies, allowing new perspectives on the treatment of obsessive-compulsive disorder and Tourette syndrome patients.

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Childhood Obsessive–Compulsive Disorder: A Prospective Follow‐up Study

Cited by 181 publications

References 37 publications

5-HT2A promoter polymorphism −1438G/A in children and adolescents with obsessive-compulsive disorders

5-HT2A promoter polymorphism −1438G/A in children and adolescents with obsessive-compulsive disorders

The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome

As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette

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