Childhood Obesity and the Role of Dopamine D2 Receptor and Cannabinoid Receptor-1 Gene Polymorphisms

Araz, Nilgün Çöl; Nacak, Muradiye; Oğuzkan-Balcı, Sibel; Benlier, Necla; Araz, Mustafa; Pehlıvan, Sacide; Balat, Ayşe; Aynacıoğlu, A. Şükrü

doi:10.1089/gtmb.2012.0244

Cited by 14 publications

(9 citation statements)

References 24 publications

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“…The rs1049353 mutant allele was associated with lower BMI in six European populations and with decreased fat mass in a Danish population (n = 783) . Conversely, homozygosity for the rs1049353 mutant allele was associated with higher WHR and WC in obese men ( P < 0.01; n = 1064) and with increased childhood obesity in a European population ( P = 0.01; n = 200) . The majority of associations with rs1049353 were neutral (90%) (Table ).…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Doris

Millar

Idris

et al. 2018

Diabetes Obesity Metabolism

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The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to adiposity and glucose metabolism. Database searches identified 734 articles, of which 65 were included; these covered 70 SNPs in genes coding for cannabinoid receptors 1 and 2 (CB , CB ), fatty acid amide hydrolase (FAAH) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD). No studies included SNPs relating to monoacylglycerol lipase or diacylglycerol lipase. The CB receptor SNP rs1049353 showed 17 associations with lower body mass index (BMI) and fat mass (five studies). It also showed three associations with lower insulin levels (one study). Conversely, the CB receptor SNP rs806368 was associated with increased BMI and waist circumference (two studies). The FAAH SNP rs324420 was associated with increased obesity (three studies). A haplotype of NAPE-PLD was associated with decreased BMI (one study). A total of 60 SNPs showed no association with any measured outcome. This review suggests a complex but important role of ECS SNPs in energy and glucose metabolism.

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Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Doris

Millar

Idris

et al. 2018

Diabetes Obesity Metabolism

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“…In a recent study in Turkey, Araz et al . found that 1359G/A polymorphism in cannabinoid receptor‐1 ( CNR1 ) genes was associated with childhood obesity . In a recent genetic association analysis of 30 genes related to obesity in a European American population, rs912127 in HTR2A was associated with obesity .…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms in genes related to risk‐taking behaviours predicting body mass index trajectory among Mexican American adolescents

Zhao

Wilkinson²,

Shen

et al. 2016

Pediatric Obesity

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Objectives Obesity is associated with multiple health problems and often originates in childhood. The purpose is to investigate the associations of genetic polymorphisms in genes related to risk-taking behaviors with body mass index (BMI) trajectory over adolescence among Mexican Americans. Methods This study included 1,229 Mexican American adolescents who participated in a large population-based cohort study in Houston, Texas. BMI data were obtained at baseline and two follow-ups. The median follow-up time was 59 months. Participants were genotyped for 672 functional and tagging variants in genes involved in the dopamine, serotonin, and cannabinoid pathways. Results After adjusting for multiple comparisons, three genetic variants, namely rs933271 and rs4646310 in COMT gene, and rs9567733 in HTR2A gene, were significantly associated with BMI growth over adolescence. Using those three variants, we created an allelic score, and the allelic score was associated with BMI growth over adolescence (P<0.001). With the increase number of variant allele, the rate of BMI growth over adolescence was slower. Finally, we identified another two genetic variants, namely rs17069005 in HTR2A gene and rs3776511 in SLC6A3A gene, were associated with obesity at last follow-up. Conclusions The results suggest that genetic variants in selected genes involved in dopamine and serotonin pathways have noticeable effects on BMI over adolescence.

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“…For example, in two studies with Turkish obese children the variant allele frequency was 51.0% in one 57 and only 20.0% in the other research. 58 In the Netherlands, the A1 allele frequency was 18.3% in obese children 59 and in NorthAmerican studies with obese children, it ranged from 17.0% 60 to 38.5%. 61 In a Brazilian study with obese and normal weight (controls) children, the A1 allele frequencies were 34.5% and 23.0%, respectively, and a statistically significant association between the A1 allele and obesity was verified.…”

Section: Drd2 Taqia Polymorphismmentioning

confidence: 98%

Basic and Genetic Aspects of Food Intake Control and Obesity: Role of Dopamin Receptor D2 TaqIA Polymorphism

Pinto¹,

Cominetti²,

Cruz³

2016

Obes Res Open J

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Regulation of food intake, energy expenditure and store are strikingly linked to obesity. Homeostatic control of food intake, hunger and satiety involves adipose and gastrointestinal hormones, such as leptin, insulin and ghrelin, which eventually affect neuronal signaling in the hypothalamus arcuate nucleus. On the other hand, hedonic control of food intake relates to substances such as opioids, endocannabinoids, gamma-aminobutyric acid, serotonin and dopamine, which act on the motivation and reward mechanisms. Dopamine is a precursor of noradrenaline and adrenaline and modulates a number of physiological functions, such as appetite, depending on the brain area and the type of receptor stimulated. It has been established as the main neurotransmitter of the hypothalamic reward system. Beyond the homeostatic and hedonic energy balance control, genetic aspects are also tightly involved in obesity pathophysiology. In this context, some Single Nucleotide Polymorphism (SNP) has been linked to common obesity. Here, we highlight the role of the dopamine receptor D2 gene TaqAI polymorphism, which affects the D2 receptor availability and has been associated to obesity. Therefore, the aim of this mini review is to cover basic aspects of food intake, energy balance, dopamine-related aspects, including genetic ones, and the relation with obesity.

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Childhood Obesity and the Role of Dopamine D2 Receptor and Cannabinoid Receptor-1 Gene Polymorphisms

Abstract: No significant difference was found between genotypes and alleles of DRD2 Taq1A and DRD2 Taq1B polymorphism in patients and controls, while the CNR1 receptor 1359G/A polymorphism and the presence of the A allele may be one risk factor for susceptibility to obesity.

Cited by 14 publications

References 24 publications

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Genetic polymorphisms in genes related to risk‐taking behaviours predicting body mass index trajectory among Mexican American adolescents

Basic and Genetic Aspects of Food Intake Control and Obesity: Role of Dopamin Receptor D2 TaqIA Polymorphism

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